Constantin

building something new in Bio
previously MD @ Muw and Harvard, Telos Circle, the residency

[the residency @theresidency]

the super hacker who got kicked out of college builds the .1 hacking agent in the world @KinoSecOfficial

[Constantin @convalexius]

@_sethmorton @beffjezos @CIMCAI @stephen_wolfram It is, I have it show you the PhD thesis of a friend. He talks just about this.

[Constantin @convalexius]

@beffjezos @CIMCAI @stephen_wolfram Biology in a nutshell

[Constantin @convalexius]

I see your logic, but that’s not how it works pharmacologically. The absolute mg amount sounds tiny, but semaglutide has a ~1 week half-life, while native GLP-1 is cleared within minutes.

0.1 mg semaglutide ≈ 24,000 pmol. A normal post-meal active GLP-1 pulse is roughly 15–30 pmol circulating at a time. So by molecule count that’s ~800–1600x a physiological plasma pulse, with vastly longer exposure.

Placebo may contribute, sure. But “0.1 mg = nothing” is the wrong calculation.

[Constantin @convalexius]

It was tested on obese and or diabetes patients mainly for controlling blood sugar. There are few studies just for weight loss and if, then also on obese patients.
There are no studies, at least to my knowledge, testing it in healthy patients but for weight control. It’s totally feasible that it works. I’d love to see studies on this, that’s what Eric’s post was about initially

[Constantin @convalexius]

@VraserX The latter

[Constantin @convalexius]

Every day I work on realizing a future like this. Accelerate.

https://t.co/LigS5Hy7xQ

[Constantin @convalexius]

@redcypress0 @EricTopol Of course could be

[Constantin @convalexius]

@action_junkie @jeremychrysler @EricTopol No the supplier has to claim that, for safety reasons. Keep it refrigerated and clean the membrane with alcohol and your good

[Constantin @convalexius]

This is not part of a study, I’m not claiming this will work for everyone. I’m a health 24 year old guy who can stay at 10% with more willpower and discipline. Ozempic makes it easier. This is just self reporting. Btw we have a biohacker group of 8 physicians taking the same dose. All report the same effect.

[Constantin @convalexius]

@fryry__ @EricTopol Officially yes, but that’s for safety reasons. There is no reason the medicine spoils if refrigerated. You just should clean wipe the membrane with disinfect. Over a couple of months the membrane gets pretty contaminated.

[Constantin @convalexius]

I track my health since 7 years. I am naturally leaning more towards hunger. With the 0.1 mg a week dose, I can very much feel the difference in appetite reduction.

Call it placebo, but we are a group of like 8 physicians that are all on the same dose and we all feel the effect. N=8 is small still.

But you can feel coffee when you drink it as well, same goes for Ozempic.

[Constantin @convalexius]

@jeremychrysler @EricTopol Yes

[Constantin @convalexius]

We have a new model sir

[Claude @claudeai]

Introducing Claude Opus 4.8: it builds on Opus 4.7 with sharper judgment, more honesty about its own progress, and the ability to work independently for longer than its predecessors.

Available today at the same price.

[Constantin @convalexius]

Obviously Ozempic is decreasing motivation and drive.

https://t.co/uhvc1wC7X7

[Constantin @convalexius]

@rand_longevity @davidasinclair That’s not why we age

[Constantin @convalexius]

@davidasinclair Yes, and managing the balance between Trithorax and PRC2 seems like a promising path forward. Shouldn’t we be working on ways to stabilize these complexes and preserve epigenetic state over time? @davidasinclair

[Constantin @convalexius]

@kimmonismus Europe is not for the ambitious

[Constantin @convalexius]

@iruletheworldmo Here’s the answer
https://t.co/fL1CrFCGK2