Christopher Smillie

Assistant Professor @HarvardMed @MGHMedicine @broadinstitute | human microbiome, evolution, mucosal immunology, computational biology

[Christopher Smillie @cssmillie]

Excited to share the Smillie Lab's first paper!

We discovered distinct lineages of the gut microbiota that are exquisitely adapted to inflammatory disease.

This was a monumental effort led by Adarsh Kumbhari @mgh_ri @harvardmed @broadinstitute

More: https://t.co/rmfnCdyORP

[Christopher Smillie @cssmillie]

@Nature @heidiledford Our recent work:

Discovery of disease-adapted bacterial lineages in inflammatory bowel diseases
https://t.co/51Bj25IjlC

[Christopher Smillie @cssmillie]

Excited to see our recent paper profiled by @Nature! Thanks to @heidiledford for the fantastic article. Congratulations to the Lee and Doffinger labs on their recent discoveries. Exciting times for IBD research! https://t.co/Yq3iMG9Xd1

[Christopher Smillie @cssmillie]

@Nature @heidiledford The two other publications covered in the article:

A disease-associated gene desert directs macrophage inflammation through ETS2
https://t.co/snAWdUKakn

Autoantibodies against Interleukin-10 in Inflammatory Bowel Disease
https://t.co/M086CAZj8U

[Christopher Smillie @cssmillie]

Many thanks to @adarsh_k1, @thomasnhcheng, @AshwinMDIBD, @bkocharmd, and @TheXavierLab on this team effort!

[Christopher Smillie @cssmillie]

Excited to share the Smillie Lab's first paper!

We discovered distinct lineages of the gut microbiota that are exquisitely adapted to inflammatory disease.

This was a monumental effort led by Adarsh Kumbhari @mgh_ri @harvardmed @broadinstitute

More: https://t.co/rmfnCdyORP

[Mathieu Groussin @mgroussi]

PhD opportunities to join our lab! IMPRS is a great graduate school. Check it out! Deadline for applications: May 15th - contact us if interested 😉

[Christopher Smillie @cssmillie]

Congrats Itzhak Khait, @Ohad_LE, and @HadanyL for their brilliant use of #ML to study plant communication by sound! Ohad is a new postdoc in our lab who is studying how the #microbiome controls its human host - excited to see what he comes up with next!
https://t.co/MJSfFWheUP

[Christopher Smillie @cssmillie]

Also congrats to Shivam Gandhi on his stellar contributions to this paper! He will make an amazing graduate student this fall.

[Christopher Smillie @cssmillie]

Congrats to our collaborators Peijun Ma and Deb Hung on publication of BacDrop, a new method for bacterial #singlecell RNA-seq. Highly scalable methods will be essential for studying the transcriptional heterogeneity of pathogens and the #microbiome.
https://t.co/Uvw8iQDzjO

[Lynne Chantranupong @Lchantran]

Very excited to share our work that defines how dopamine and acetylcholine interact in the brain during decision making! https://t.co/vCQA2hMSLJ

[Christopher Smillie @cssmillie]

Great lab @HarvardChanSPH for genomics, lung biology, and asthma!

[Adam Haber @haber_lab_hsph]

We are looking for awesome computational postdocs to work on a range of projects, please share!

[Martin Polz @MartinPolz]

Congratulations to Fatima Hussain @fatiays and @JavierDubert on their new paper in Science describing surprising ways how bacteria in the wild defend themselves against phage. See also perspective by Perspective by Meaden and Fineran.
https://t.co/UdkcGAjyRo

[Christopher Smillie @cssmillie]

The Smillie Lab is hiring for an exciting collaboration @broadinstitute to identify microbiome products that control gut disease. We are a new computational lab @harvardmed @mghmedicine studying #microbiome #immunology #metabolomics #ML. Please share! https://t.co/uKyEHqvaLe

[Matan @matanhofree]

We are excited to share our study on spatially organized multicellular immune hubs in human colorectal cancer https://t.co/tzJxdLaLTn @CellCellPress. Joint effort with @karin_pelka, @chenchirps, @AnaAndersonlab, Orit Rozenblatt-Rosen, Aviv Regev, Nir Hacohen, many others!

[Alex Cagan @ATJCagan]

I am incredibly excited to share our preprint ‘Somatic mutation rates scale with lifespan across mammals’In this paper we provide an unprecedented description of somatic mutation across mammals.

https://t.co/qjOV7NrWS5

An illustrated tweetorial…[1/17]

[Fabian Theis @fabian_theis]

Happy that our single-cell meta-analysis of SARS-CoV-2 entry genes is out @NatureMedicine. Headed by Chris Muus & @MDLuecken in a big effort of the whole @humancellatlas Lung Network, we find age&sex-dependent cell-type specific effects across 31 studies.
https://t.co/nH6yLbw7Jy

[Christopher Smillie @cssmillie]

The Smillie Lab opens March at @MGHMedicine! We develop methods (wet/dry) to understand microbial life on the human body #microbiome #singlecell #evolution #deeplearning. Hiring grad students, postdocs, and RAs @harvardmed @broadinstitute. Please share! https://t.co/uKyEHqvaLe

[David R. Liu @davidrliu]

Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11 https://t.co/O7dkEYpndg

[David Fawkner-Corbett @davefc88B]

Really excited to see our work out mapping the development of the human intestine at single cell resolution. An amazing amount of work from a fantastic team.

https://t.co/cYqt5sgoau

[Otto X. Cordero @oxcordero]

Proud to share our latest work showing that interactions between strains govern the eco-evo dynamics of microbial communities, led by Akshit Goyal @eltanin4, Leonora Bittleston @leonorabit and Gabriel Leventhal @gaberoo ... https://t.co/5fQYn2DrAY