Prólogo
Sin proponérmelo al principio, he consagrado mi ya larga vida a las letras, a la cátedra, al ocio, a las tranquilas aventuras del diálogo, a la filología, que ignoro, al misterioso hábito de Buenos Aires y a los perplejidades que no sin alguna soberbia se llaman metafísica. Tampoco le ha faltado a mi vida la amistad de unos pocos, que es lo que importa. Creo no tener un solo enemigo o, si los hubo, nunca me lo hicieron saber. La verdad es que nadie puede herirnos salvo la gente que queremos. Ahora, a los setenta años de mi edad (la frase es de Whitman), doy a la prensa este quinto libro de versos.
ELOGIO DE LA SOMBRA
Editorial EMECÉ (1969).
Genetic kidney diseases represent a heterogeneous group of disorders characterized by de novo, inherited, polygenic, and gene–environment abnormalities. In this article, the authors argue that limitations of treating monogenic kidney diseases with individualized ASO at present hang less on the technology than on the identification of patients with amenable genotypes for such medicines. https://t.co/0ir1p28mmO
The KDIGO 2025 Clinical Practice Guideline for Anemia in Chronic Kidney Disease (CKD) is available for public review through Friday, November 22.
You can download the public review draft and share comments via the feedback survey on the KDIGO Anemia in CKD Guideline Website: https://t.co/gK2lWvFfSi
KDIGO will prepare a final version for publication based on feedback received during public review. We thank you in advance for your time and insights.
#anemia #CKD
Vaptans were developed at the end of the previous century as V2R antagonists. This study demonstrated, employing diverse translational techniques and minimizing animal use, MQ232's safety and efficacy in several rodent models of hyponatremia and ADPKD.
https://t.co/cg3J6V0XUe
The complement system plays a central role in the pathogenesis of IgA nephropathy. This study found that an early, sustained, and clinically meaningful reduction in proteinuria and trend toward stabilization of eGFR were observed with ravulizumab versus placebo. https://t.co/sqeXj1ANhj
#KidneyWk
#LBCT
I encourage you to join NHGRI on October 15 at 10 a.m. ET for an important and informative webinar entitled “Ancient Genetic Clues into Modern Human Disease.”
Gracias a la Universidad de la Costa en Barranquilla por recibirme durante su “International Week”. Mucha suerte a todos los #investigadores que quieren aplicar a los fondos del @HorizonEU 🇪🇺🫶🏻🇨🇴
DNA and RNA are both generating plenty of research insights to go around! There is a lot of exciting research about RNA and there are new technologies emerging to fully sequence RNA and all of its different chemical modifications.
A transcriptome is all of the RNA in a cell, just like the genome is all of the DNA in a cell!
Scientists often look at transcriptomes because the transcriptome can reveal how that cell is responding to a specific change.