Dami Gupta

[Tom Dörr @tom_doerr]

Covers full academic research pipeline for Claude Code

https://t.co/4Mk2QHXMFg

[Dami Gupta @damigupta]

@Nature @NatureBiotech Oh no … RIP

[Broad Institute @broadinstitute]

Have you ever wondered what animal superpowers can teach us about our own DNA? Join us in Cambridge, MA (or online) for a Broad Discovery Series talk on Wednesday, May 20 at 6 pm ET with @eenork of @darwinsarkfnd. Register: https://t.co/pQfSkgg4Pn

[Eric Topol @EricTopol]

Very good thread, explainer on the new LLM paper @ScienceMagazine

[Ming "Tommy" Tang @tangming2005]

Anthropic just published best practices for Opus 4.7 with Claude Code. The biggest changes:

Default effort is now "xhigh" (new level between high and max).

Fixed thinking budgets are gone. The model decides when to think deeply on its own.

[Dami Gupta @damigupta]

Updated: Ask a frontier genomic foundation model (Evo2) about your DNA variant !
AskEvo2 : https://t.co/F5USYlYn3F

Get Evo 2 DNA variant log-likelihoods in your browser - no Docker, no GPU, no API keys, no login.

Paste ref and alt sequences : get wild-type + mutant log-likelihoods. Single variant and batch modes available.

Validated against ClinVar: BRCA1 AUC=0.90, MLH1 AUC=0.95, n=200 each. Results are raw Evo2 model outputs (no supervised linear probing or retraining applied).

Runs via a Modal backend, hosted on Hugging Face Spaces.

@goodfire_ai @arcinstitute @pdhsu @garykbrixi @NVIDIAHealth

[Dami Gupta @damigupta]

@LukeParkerDev @plainionist The tests are ‘is not none’ and ‘is string’ !!!

[Dami Gupta @damigupta]

@Aaronontheweb Spot on !

[Dami Gupta @damigupta]

@dioexul @rezoundous True dat

[Dami Gupta @damigupta]

@CodveAi @unclebobmartin Or drunk interns. Or golden retriever, eager to please puppies

[Dami Gupta @damigupta]

@hiarun02 Well said

[Dami Gupta @damigupta]

@camsoft2000 Exactly, and if you express these thoughts, there will be a ton of people commenting on your lack of skills files , under using the plan mode and blah blah

[Dami Gupta @damigupta]

@camsoft2000 Copy pastes ! Absolutely!

[Dami Gupta @damigupta]

@LuizaJarovsky I don’t think it’s small

[Dami Gupta @damigupta]

@MaxEllison2048 @francoisfleuret They can make something … but how long will it last ?

[Dami Gupta @damigupta]

@EricTopol @NatureBiotech @VishRao5 @serena2z @BrianPlosky @pdhsu @BoWang87 @james_y_zou @marinkazitnik @pranavrajpurkar Making it easy to Ask Evo2

https://t.co/6b6w3Cx4hh

[Dami Gupta @damigupta]

@rezoundous Claude doesn’t get the big picture

[Dami Gupta @damigupta]

@tangming2005 @anshulkundaje @genbioai What do you think of the goodfire findings ? It could help decrypt non coding variants , or find similar regulatory regions .