Dan Gorski

Interested in single-cell genomics, programming and extracellular matrices -

[Christian Jung @cjungMD]

This is the evening and the morning view from our catheterization lab and #IntensiveCareUnit @UniklinikDUS - you want to join us or do cutting edge 🔥#research ? - let me know! @HHU_de @HeiCAD_HHU @GerdesLab @studium_med_hhu @GrandochLab @WolffGeorg @LucasBusch14 @alexbejimd

[Dan Gorski @danieljgorski]

Hi, single-cell world 👋. Does anyone know of any method/package that performs differential gene expression in a cluster-independent manner, similar to how miloR from @emmamarydann does DA analysis?

[Renato V. Iozzo, MD PhD (Honoris causa) @iozzo_v]

Dear proteoglycan lovers, I am happy to announce the birth of Proteoglycan Research, a new open-access journal published by Wiley. This new journal is devoted to all research on proteoglycans, hyaluronan, sulfated-glycosaminoglycans, and related molecules. https://t.co/AoUH8PF2xC

[Leslie Vosshall PhD @leslievosshall]

We're doing a thing! Speakers @HHMINEWS Science Meetings will no longer put journal names on their talk slides.
Instead display first author, year, PMID (or DOI) like @ardemp
Why?
-end prestige-signaling
-people can actually find reference
#nojournalnamesontalkslides

[Dan Gorski @danieljgorski]

Happy to share our work on HAS3 after cardiac ischemia: https://t.co/ZtB5ZRq8sR

[Prabhu Mathiyalagan @Prabhu_gene]

Fibrosis aficionados: Agree or disagree?

After working for years on cardiac fibrosis, now on lung fibrosis at a fibrosis-focused company, one thing I can say for sure: we are far away from understanding fibroblast biology.

Also: Fibrosis isn’t just about fibroblasts. Period.

[Livnat Jerby @LivnatJerby]

Excited to share that our @NatureBiotech paper with Aviv Regev on Multicellular Programs (MCPs) is now out with a fully automated data-driven method to identify MCPs from #singlecell or spatial data #behindthepaper: https://t.co/k7kPmW4NF0 https://t.co/bgcmYxPwnB (1/19)

[Paul Bollyky @bollyky]

Hyaluronan is implicated in many chronic inflammatory and fibrotic diseases. Our clinical trial showing that oral hymecromone inhibits hyaluronan synthesis is out: https://t.co/dNAg9wLtU4. Congrats to Nadine Nagy, @joellerosser, @SallyDemirdjian, @ebburgenerMD & the team.

[Dan Gorski @danieljgorski]

Very happy to share our work on how the #hyaluronan matrix influences lesion stability in #atherosclerosis. To our surprise, HA/CD44 regulates SMC phenotype via acute-phase proteins!

[Circulation Research @CircRes]

Hartmann & colleagues found the #hyaluronan matrix controls #collagen deposition by modulated #SmoothMuscleCell phenotype transition and plaque stability. Learn more about #atherosclerosis lesion stability at https://t.co/t1PZKAUEYw

@danieljgorski @aacnewman13 @HHU_de

[Dr. Alexandra Newman @aacnewman13]

We spent a few years trying to fit the observations in this paper into the accepted knowledge about #SMC and their contribution to lesion stability in #atherosclerosis but as scRNAseq became ubiquitous, these results started to make a lot more sense. Read why! @lab_owens @UVACVRC

[Circulation Research @CircRes]

Hartmann & colleagues found the #hyaluronan matrix controls #collagen deposition by modulated #SmoothMuscleCell phenotype transition and plaque stability. Learn more about #atherosclerosis lesion stability at https://t.co/t1PZKAUEYw

@danieljgorski @aacnewman13 @HHU_de

[Stacey Sims @SimsScienceNews]

CIRCULATION RESEARCH | Editor's Picks | October and November 2021
@AHAScience @CircRes

https://t.co/atIWFt9Nwv

[Hao Yin @HaoYin20]

#SmoothMuscleCell HAS3 KO -> ⏫Lgals3+ACTA2low transitioned SMC subtypes
+⏫acute phase response (Lcn2, C3, SAAs)
+⏫Collagen synthesis
+⏫plaque stability in🐭#Atherosclerosis

+Direct roles of⏬HA-CD44 axis &⏫Lcn2

Dr. Jens Fischer labs @CircRes 2021
https://t.co/EEs4r7yC4R

[Tobias Marschall @tobiasmarschal]

Please RT: Excited to share that we have an opening for a full professorship in Machine Learning for Medical Data (deadline Sept 23). Happy to answer questions. Very much looking forward to future projects with the successful candidate! https://t.co/fwPZenr2XD

[Rahul Satija @satijalab]

Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on March 26. Talks will feature recent exciting computational and experimental advances and will be livestreamed at https://t.co/zG98gkckMU. Please RT/spread the word!

[JACC Journals @JACCJournals]

The extracellular matrix provides important structural and regulatory roles in establishing tissue architecture and cellular function. Read more about its importance in #CVD in the first paper of a four-part Focus Seminar in this week's issue: https://t.co/C0bi8qqgoZ #JACC

[Daniel J Drucker @DanielJDrucker]

Sweet vs. Diabetic fibroblasts and cardiac fibrosis https://t.co/FlMRD4Z3Tu

[Muscle Cell News @musclecellnews]

@HHU_de Cardiac researchers looked at fibroblast activation and hyaluronan synthesis in response to hyperglycemia and diet-induced insulin resistance https://t.co/rrjWorT0Lo

[Dityatev Lab @DityatevL]

Cardiac fibroblast activation and hyaluronan synthesis in response to hyperglycemia and diet-induced insulin resistance - https://t.co/VURelG3HMZ

[Dan Gorski @danieljgorski]

Cardiac Hyaluronan Synthesis Is Critically Involved in the Cardiac Macrophage Response and Promotes Healing After Ischemia Reperfusion Injury | Circulation Research #hyaluronan #macrophage #myocardialinfarction #ischemiareperfusion https://t.co/W28DRMfQAD