DNA 🧬 (Danielle Andrzejewski)

COO @protocollabs (PL Infra) | Prev: COO @cLabs (@celo), Head of BD @a16zcrypto | crypto since '16

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

Evolve or die.

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

@AlexAndBooks_ Couldn’t agree more. Proudly consider myself a tsundoku master!

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

@AdamMarblestone Amazing!! Congrats to you and the team, Adam!

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

@TheDeyDream @heavyspoilers Came to the comments for this exact reason…

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

Enjoy the process of exploration, expand the breadth of your skillset and knowledge, and establish a curiosity-driven mindset.

The well-rounded human becomes more resilient as identity extends beyond a single specialization.

In short: have fun along the journey.

[Brad Stulberg @BStulberg]

A massive new study on peak performance included 34,000 international top performers: Nobel laureates, renowned classical music composers, Olympic champs, and the world’s best chess players. It shows early specialization is a trap, and the road to greatness is long and varied.

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

@arthurbrooks Research continues to showcase that spirituality is a key ingredient of psychological resilience. Applying this to a relationship, I imagine, not only builds intimacy, but also relational resilience.

(Really enjoying @MatthewSacchet ‘s research on this.)

https://t.co/Zs4ZLiE0m0

[Matthew D. Sacchet @MatthewSacchet]

Announcing the first results from our Program’s phenomenology research: advanced meditators’ report the extraordinary, and so far overlooked, potential of meditative development for mental health.

Mindfulness is widely recognized for its mental health benefits, yet growing evidence suggests that skill-based proficiency, not simply time spent practicing, is what predicts the most profound psychological change. Still, very little research has examined what happens when meditation is developed through advanced meditation states, stages, and endpoints as potential gateways to the deepest, most healing forms of well-being.

Our latest study provides the first-ever systematic analysis of advanced meditation in relation to mental health and well-being. This work is based on in-depth interviews of 28 advanced meditators who attest to radical, wide-spectrum, non-linear improvements in mental health. This qualitative research provides a foundation for increasingly rigorous multidisciplinary investigation.

Across participants, reports indicated:
— Large, stable increases in baseline well-being
— Heightened positive attitudes including openness and acceptance
— Enhanced clarity, attentional stability, and cognitive balance
— Positive shifts in life orientation, prosocial values, and interpersonal functioning
— Transformative improvements in mental health conditions

Participants described advanced meditation as affecting them at a deep psychological level. A recurring theme was a profound reduction in suffering and an expanded capacity to meet difficulty. As one put it:
“Not only did it save my life…I could get the worst news in the world right now, and I would be able to absolutely cope with it in the most wholesome way possible.”

Some described enduring reductions in self-focused rumination as a result of their advanced practice:
“Negative self talk, just seemed to drop…like 80% of it left and never returned.”

Most striking were reports of major improvements—or full resolution—of conditions such as anxiety, panic disorder, ADHD, trauma-related symptoms, addiction, and anger-related disorders. One participant claimed that their ADHD ceased completely after 12 years of practice; another, reflecting on reported recovery from panic, trauma, and suicidality, said:
“I’m happier than I’ve ever been.”

Echoing the ethos of our Program, first author Sebastian Ehmann, alongside co-authors Vanessa Naughton and Terje Sparby @terjesparby, argues that these findings highlight the importance of studying meditative development for psychiatry and public health—especially amid the global mental health crisis. Understanding how systematic reductions in self-centeredness and rigid self-identity, along with insights into one’s life and experience, can lead to profound psychological freedom that may be essential for designing highly effective, scalable, and personalized interventions.

We appreciate everyone in our growing community who reads and shares this work!

Full preprint ⤵️

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

@aishdoingthings @analoguegroup Such a great resource! @juanbenet you might enjoy this also

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

No one is coming to save you.

… which is why your relationship with yourself is the most important in your life. How you feel reading the statement above (excited vs terrified) reveals the state of your self-relationship.

[Dr. Julie Gurner @drgurner]

You cannot rely on anyone but yourself.

Once you understand that - and really take it in..
You should know exactly what you need to do.

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

@TaraViswanathan @unltdindustries @alexmodon @_jordanstern Congrats!! 🎉

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

@davidu Empathic agreement! Nutty Buddies are unparalleled

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

@lukeburgis This! Yes! It’s the refined sister to typical filler words

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

Any chance @microHQ is aggregating GPTs for queries, @thatguybg ?

Would be really powerful to add onto the Self Layer yall are building with email, messaging, calendar, etc

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

Is there a consumer-grade, interoperable orchestration layer for individual AI interactions yet?

As competing models continue the neck and neck race of improvement, I just want a single, user-friendly tool that:
- holds my portable, provider-agnostic “memory” (all chats, preferences, notes)
- routinely routes each query to the best model across multiple providers

Who is building this?

[Google DeepMind @GoogleDeepMind]

This is Gemini 3: our most intelligent model that helps you learn, build and plan anything.

It comes with state-of-the-art reasoning capabilities, world-leading multimodal understanding, and enables new agentic coding experiences. 🧵

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

my understanding is that:

Mem0, Zep, and MemMachine are more dev infra than consumer products.

Jan, LM Studio, and Ollama are more for cross-platform inquiry rather than shared contextual memory & data.

OpenRouter is aimed at developers and requests (not personal data).

[gavin leech (Non-Reasoning) @gleech]

one more then I'm off to the pub

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

My waking thought today was about magnetic personalities and physio/nueral implications. This led to reading research papers on biophoton emission, bioelectric fields, biomagnetic fields, and physiological synchrony. Following your thesis that ideas might find you, it’s fun to have stumbled upon your article today also.

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

“You will never be perfect, but you can always be better.”
- Warren Buffet

Looking forward to his annual Thanksgiving message before “going quiet”

https://t.co/BzMx47r2JX

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

@JoshHochschild @lukeburgis Cluny campus? 👀

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

@ArthurMacwaters Reminds me of Lincoln! After the Civil War broke out, he asked the Library of Congress for all the books on war.

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

@APompliano Stumbled upon this excellent essay on theoretical physics, quantum time, and the formation of reality. The author does a great job building the topics slowly so most readers can follow along.

https://t.co/tqSAyP6PxG

[DNA 🧬 (Danielle Andrzejewski) @danielle_a2z]

@pauljpastor This sounds like a dream! Looking forward to reading the essay.