Daniel Morganstein

Consultant Endocrinologist.

[Daniel Morganstein @DanielMorganst2]

@graham74GC DPP-4 is expressed in lymphocytes. Is this really SGLT-2 being protective or an impact of inhibiting DPP-4 on lymphocytes behaviour?

[Daniel Morganstein @DanielMorganst2]

Opportunity for a Pan-London Cancer Research Fellowship to study the impact of steroid induced hyperglycaemia during chemotherapy - with me, @Lennae13 and @PinkieChambers

https://t.co/iCYzO0LJfA

[Royal College of Physicians @RCPhysicians]

Yesterday we launched the updated acute care toolkit 7.

A must-read for all physicians caring for patients with cancer who are admitted to acute care: https://t.co/pNTDuNvcc9

@acutemedicine

[Endocrine Connections @EndoConnect]

'Diagnostic criteria and proposed management of immune-related endocrinopathies following immune checkpoint inhibitor therapy for cancer' - a recently published review by Ruth Percik et al.
Read it now: https://t.co/aVpkapWZy4

[UKINETS @UKINETS]

NETs for Newcomers 2023 - Programme now LIVE on our website: https://t.co/kDnawz7WQn Please register now!

[David James Pinato 🇺🇦 @DJPinato]

Type 2 diabetes mellitus may influence efficacy outcomes from immune checkpoint blockade in patients with cancer 🔥 - proud to publish our experience with @ACortelliniMD @A_DAlessioMD @ImperialSandC @ImperialBRC @UniAvogadro @AACR @myESMO @ASCO

https://t.co/ft3cMWIpOS

[Neuroendocrine Cancer UK #NotJustNECancer @ncukcharity]

NETs for Newcomers
Thursday 18th May 2023 Birmingham, UK. Full details here: https://t.co/HBf6Oc9N6x #NeuroendocrineCancer #NETs @RoyalFreeNHS @ImperialNHS @TheChristieNHS @LeedsHospitals @SheffieldHosp @NHSScotAcademy

[Daniel Morganstein @DanielMorganst2]

Please to share our paper in @DiabeticMed mapping diabetes and hyperglycaemia after immune checkpoint inhibitor therapy. @EndoLWBC @DrSanjayPopat

Hyperglycaemia following immune checkpoint inhibitor therapy—Incidence, aetiology and assessment https://t.co/F0gVuRbNzU

[CW+ charity @cwpluscharity]

A big thank you to everyone that came along to our first #CWInnovation New Horizons event today.

It was great to hear from @sadiahasnain, Dr Rachael Jones, Dr Sara Day and @DanielMorganst2 about Virtual Wards and Remote Monitoring @ChelwestFT.

[Daniel Morganstein @DanielMorganst2]

@hormone_doc @pash22 @ProfRobHoward @barttels2 @AlbertoEspay @MadhavThambiset @LonSchneiderMD @nvillain_alz @MemoryDoc The mechanisms differ. Almetuzumab is essentially an immunosuppressive drug and the thyroiditis is postulated to be part of an immune reconstitution syndrome. The checkpoint inhibitors ( Ipi, Pembro etc) activate and induce something resembling natural autoimmune conditions.

[Daniel Morganstein @DanielMorganst2]

@ShivaniM_KC Agree. I think a point of care test has to involve taking a sample and analysing it. If you were to use CGM in an inpatient setting more comparable to an O2 sats monitor ( not POCT) vs an ABG ( is POCT).

[Tom Newsom-Davis @tnewsomdavis]

👉 53% of diabetic NSCLC patients receiving immunotherapy ➡️ hyperglycaemia.

👉 6% non-diabetic NSCLC pts ➡️ hyperglycaemia

👉 Does not affect survival 👍

Great collaboration between @ChelwestFT and @royalmarsdenNHS

[Daniel Morganstein @DanielMorganst2]

@graham74GC How relavent is the grade system to endocrine side effects here - much like post immunotherapy need active screening and prompt hormone replacement.

[Neuroendocrine Cancer UK #NotJustNECancer @ncukcharity]

For Health Care Professionals (HCPs) only:
@NHSEngland @NHSScotland @NHSWalesDU @UKINETS @CardiffGastro @FrontGastro_BMJ @BTOGORG @M4RareDiseases @BMJMasterclass @drphiliplee1 @Medic_Russell

[JMG @JMG_BMJ]

UK recommendations for #SDHA germline genetic
testing and surveillance in clinical practice

#OpenAccess: https://t.co/go1xNuQrm7

#Cancer #GCChat #Paraganglioma #Phaeo @UKCGG
@McVeighTerri @De1Diana @tischkowitz @ER_Woodward @clare__turnbull

[Daniel Morganstein @DanielMorganst2]

@DrNicolaDavis Definitely highlight immunotherapy toxicity - as presents very differently from other oncology treatment effects - and probably more likely to present to primary care. Fatigue for example may not raise much concern in a patient receiving chemo or radiotherapy but red flag in ICPI

[Daniel Morganstein @DanielMorganst2]

@hugorifkind 2/2
But a lateral flow will miss some cases so if you have symptoms should not be using them and go direct to a PCR which is more accurate.

[Daniel Morganstein @DanielMorganst2]

@hugorifkind It’s simple:
Lateral Flow less accurate - but if used regularly in those without symptoms will pick up many who are most infectious. Despite being less accurate when there is this much COVID around a positive lateral flow is almost certainly a true positive. 1/2

[Daniel Morganstein @DanielMorganst2]

@Maherjane @KathrynBanfill @Existential_Doc @hormone_doc Agree - the cumulative steroid doses used to treat some IRAE are eye watering, largely due to the prolonged courses. They need glucose monitoring and bone protection like any other long term steroid group.