Daniel Zabransky

Assistant Professor of Oncology at Johns Hopkins. Medical Oncologist studying the intersection of aging and pancreatic cancer (and some other things, too!).

[Mark Yarchoan @MarkYarchoan]

Older adults respond well to anti-PD1 despite age-related immune differences, @danielzabransky
Findings may not extend to therapeutic cancer vaccines, which likely require naive T cells
Summary of findings below⏬
🔗 https://t.co/BU30IaVhjT

[Daniel Zabransky @danielzabransky]

5/ We hope this study will help identify aging-related signals and pathways that can be further evaluated and targeted for personalized immunotherapy approaches for patients.

[Daniel Zabransky @danielzabransky]

1/ Excited to share our study (https://t.co/4EuMTyJ5Hx) published today in @NatureComms led by @ChesterKao1, @SorenCharmsaz, and Hua-Ling Tsai evaluating age-related differences in immune responses in patients with cancer treated with immune checkpoint inhibitors (ICIs).

[Daniel Zabransky @danielzabransky]

4/ These differences in older patients included diminished cytokine responses, reduced pools of naïve T cells with increased relative expression of immune checkpoint molecules, and more robust effector T cell expansion in responders compared to non-responders.

[Jennifer Bailey-Lundberg @DuctalvsAcinar]

🔬Ready to delve deep into the #TumorMicroenvironment @AACR? Join @LabMcgaha and me as we co-chair the symposium “The Microenvironment: Beyond Surrounding the Tumor.”
Featuring talks by @ChetritNir @danielzabransky @neilqtay @GauriMirji Jun Li, Ruiyuan Xu, & Xiaoyu Yuan #AACR24

[Cancer Research @CR_AACR]

If you enjoyed the talk by @danielzabransky at #AACR24 during the Microenvironment session, be sure to read his recent paper on aged fibroblasts in #pancreaticcancer.
https://t.co/YG5nEEPTF3
@AACR

[Bloomberg Distinguished Professors @JHU_BDPs]

In a recent article, BDP @AshaniTW and @danielzabransky discuss their new study from @hopkinskimmel which addresses age-related changes in fibroblasts and their connection to pancreatic cancer progression.

https://t.co/OOpCZmksVF

[Mike Pishvaian @MPishvaian]

@HopkinsMedicine @sibleyonline @IntegrityCE @AshRajputInDC @hopkinskimmel @MarkYarchoan @marinabaretti @KLafaro @freddyeescorcia @hopkinskimmel
@HopkinsMedicine
@IntegrityCE

👍Dr. Mark Yarchoan @MarkYarchoan also led our last session of the conference - focusing on #chlolangiocarcinoma with James Harding, Chris Schubert, Jackie Birkman-Gartman, and @danielzabransky

[Professor De Silva @AshaniTW]

Ugh. I couldn’t be more proud. In the last year @FaneMitchell then @danielzabransky and now @Yash_Chhabra. And before them Marie Webster, not to mention all the others who did not take PI roads. Best part of mentoring is watching my ducklings fly 💕💕
Fly high Yash, you got this!

[Daniel Zabransky @danielzabransky]

@Aiims1742 @CR_AACR @DrLizJaffee @AshaniTW @hopkinskimmel Thanks for reading! We are so excited to continue studying how aging impacts pancreatic cancer progression. Have to express my immense gratitude to @AshaniTW and @DrLizJaffee who have given me so much support during my fellowship and now as I've started my own lab.

[Anirban Maitra @Aiims1742]

Great to see this work out in @CR_AACR. Led by @danielzabransky and co-mentored by @DrLizJaffee and @AshaniTW @hopkinskimmel
Fibroblasts in the aged pancreas drive #PancreaticCancer progression
https://t.co/pgaMGMHilR
Neat example of convergence science.

[Paula Hurley @HurleyLab]

Loved working with @HongYuenWong @JGordetsky TigerSheng @K_Schaffer @VUMCurology @GA_Giannico @JeffRathmell @benhopark on a single-cell #RNAseq study to better define cribriform #prostatecancer and its TME in @NatureComms.
@VUMC_Cancer
https://t.co/ZiLankQUB4

[Daniel Zabransky @danielzabransky]

@AshaniTW @HEP_Journal Thank you @AshaniTW you are far too kind! I’m lucky to have so many amazing people to work with and learn from.

[Won Jin Ho @wonjinho1]

Super proud of our team on our latest- here we directly compare the TME of 4 HCC mouse models with varying anti-PD1 sensitivities- tagging twitter users @danielzabransky @jleathe3 @SorenCharmsaz @NicoleElizGross @ltkagohara @DrLizJaffee @MarkYarchoan

https://t.co/9KLiDKztMK

[Mark Yarchoan @MarkYarchoan]

Great work from our team lead by @wonjinho1 & @danielzabransky profiling TME of murine #HCC models pub in #Hepatology
➡️Hepa 1-6: invalid ICI model, HLA mismatch w/ C57BL6
➡️Hep53.4 & RIL175 - mod ICI responsive
➡️TIBx: ICI-resistant
https://t.co/UC3fa3x3iw

[Mark Yarchoan @MarkYarchoan]

Excited to share our manuscript w/ genomic & transcriptomic data from >450 #Cholangiocarcinoma pts in JCO PO: https://t.co/tq70fajySR

➡️Actionable alterations in >30%
➡️4 molecular clusters w/ unique immunophenotypes
➡️IDH1⏫M2 mac; FGFR2⏬immune infiltrat

[Daniel Zabransky @danielzabransky]

@AshaniTW @MarkYarchoan @HeumannThatcher Thank you Ashi you are so kind!