��⚡⚡Post Hoc Analysis of the CAMERA2 Trial @legg_wamy @syctong
Risk Factors for Nephrotoxicity in MRSA Bacteraemia
Concurrent use of (flu)cloxacillin ⬆️ the risk of AKI over 4 times compared with the use of cefazolin or no beta-lactam
⬆️AUC VAN ⬆️AKI https://t.co/4I0B7T4LB3
Updated Shorter Is Better master tables with the 56th <1 day periop prophylaxis RCT included. We're just piling on at this point, no? @ABsteward
References listed at https://t.co/1oaAT6Cybb
We have enrolled our 150th participant in SNAP!!
Probably close to 5% of all patients in SAB RCTs in past 20 years.
Trial sites now enrolling in Australia, NZ, Canada.
Adults and kids.
Opening soon in Singapore, Israel, UK.
Thanks to all sites and all participants
Władysław Szpilman, a Polish pianist and composer who hid in Warsaw during the German occupation of it in WWII, playing the piece he performed for a German officer who caught him hiding in a house (Chopin's Nocturne No. 20 in C♯ minor)
@jasonroberts_pk@syctong@BradSpellberg@legg_wamy@justin_denholm Being an RNA synthesis inhibitor, I would've thought post antibiotic effect comes into play? There are some data suggesting the PAE for rifampicin is ~20-60 hours against mycobacteriums, but doesn't seem like there're any studies on staphs. Maybe an idea for an in vitro study?