Darshana Kapri

Post doc @columbia previous @TIFRScience. Mitochondria and brain. Dabbles in Machine learning.

[Neuropsychopharmacology @npp_journal]

Kapri et al. link noradrenergic signaling to hippocampal bioenergetics and spatial memory @darshanakapri @ViditaVaidya

https://t.co/zj0oHMzTqH

[Vidita Vaidya @ViditaVaidya]

Excited to see this study from @darshanakapri out in @npp_journal showing norepinephrine regulates mitochondria within hippocampal neurons via a β2-AR–Gs-cAMP–PKA-PGC-1α cascade, suggesting links between NE effects on mitochondria and cognitiion. https://t.co/X2tAyl7OJQ

[DBS TIFR @TIFR_Bio]

Congrats, @TIFR_Bio faculty @shubhatole @TIFRScience, for election as @IBROorg president. We are sure you will "further IBRO’s efforts towards diversity, equity, and inclusion” while advancing the other missions of this global neuroscience organization.
https://t.co/b5exB0vixf

[Pratik R. Chaudhari @pRATik12rc]

It was a proud moment for me to present our research work from @ViditaVaidya's laboratory @TIFR_Bio at my alma mater @ACTREC_TMC today. Thank you for the opportunity. Glad to note that cancer biologist really enjoyed a neurobiology talk!

[Praachi Tiwari @PraachiTiwari]

Great to see @Newsweek covering our recent publication. https://t.co/CWKZMdRVEx

[Praachi Tiwari @PraachiTiwari]

Very happy to finally have THE major chunk of my PhD out! @TIFRScience
Grateful to all the coauthors for their amazing contribution to this work.
Key highlights of the paper from @ViditaVaidya quoted below. But there are some side nuggets also - summarizing in a thread here:

[Vidita Vaidya @ViditaVaidya]

Really glad to have this work identifying the key role of PV-neurons in the ventral hippocampus in gating the anxiolytic actions of the serotonergic psychedelic, DOI, out in @NeuroCellPress @TIFRScience https://t.co/pfcVkxqQ8K

[Tommaso Barba @tommaso_barba]

Our new paper shows #psilocybin has similar long-term antidepressant effects as the #SSRI escitalopram but leads to greater improvements in psychosocial functioning, connectedness, and life meaning. Published in Lancet @EClinMedicine.

https://t.co/UCnQwUYTjF

🧵1/10

[DBS TIFR @TIFR_Bio]

Psychedelics provide promising future therapy for current treatment resistant-depression. @ViditaVaidya @TIFRScience history of psychedelic use, renewed interest in therapeutic uses. Shows data for the roles of serotonergic psychedelics in acute anxiolytic effects #DBSAT2024

[Martin Picard @MitoPsychoBio]

Metabolic Iceberg of Neurodegenerative Disorders

Great concept by metabolic neurologist @drmclphillips
Happy to have played a small role in this piece

https://t.co/YIQlJGNkEA

[Martin Picard @MitoPsychoBio]

A Platform to Map the Mind-Mitochondria Connection and the Hallmarks of Psychobiology: The MiSBIE Study

Preprint describing the study rationale, design, and outcome measures: https://t.co/9vEkegDbz4

[Martin Picard @MitoPsychoBio]

Is brain mitochondrial biology linked to our positive and negative psychosocial experiences?

@CarolineTrumpff looked into this question using a brain multi-omic postmortem dataset from individuals who reported their subjective experiences yearly until they died.

[BryanRoth @zenbrainest]

Whoo hoo! Major paper now out in @science :
"AlphaFold2 structures guide prospective ligand discovery"
Collaboration with @RothLabUNC @BShoichet Skiniotis, Kruse, @EnamineLtd

[Hugo Tejeda @NeuroTejeda]

When your antibody sucks and what little signal is there is just buried in background

[Martin Picard @MitoPsychoBio]

We are excited to launch our Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study page

Slides and recording of MiSBIE Transition meeting posted

Developments to come, including a Spring 2025 MISBIE Symposium

https://t.co/x9MuB16ePH

[Antara Banerjee @antarabnrj]

Will be taking my first Ph.D. student this year. Do apply if interested in reproductive endocrinology. Last date is 24th May. Check website for further details. https://t.co/AmoZhUp1Lk

[Martin Picard @MitoPsychoBio]

Today marks the transition from data collection to data analysis for our Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study.

Six years of work by dozens of people across countries—thank you! So much to learn.

https://t.co/K54pfxZr1H

[Martin Picard @MitoPsychoBio]

Preprint here: https://t.co/Tyua5UpnVS

Feedback welcome!

[Martin Picard @MitoPsychoBio]

How can you partition the frozen human brain to systematically profile mitochondrial OxPhos capacity and diversity?

Eugene Mosharov found a way to create physical brain voxels (3x3x3mm) and teamed with @MichelTdS to project results in standard MNI space.