David Goertsen

Bioengineering Ph.D.

@UBC & @Caltech alumni (he/him)

[KahanLab @anat_kahan]

How do the ovary and the brain interact with each other? Eager to explore? Wish to find solutions for neuronal-related infertility? The Kahan lab is coming soon! PhD and MSc positions are open!
https://t.co/8nF1fGzv2Y

[David Goertsen @DavidGoertsen]

My partner, @MaryIppolito6, was instrumental. She listened to me rehearse (several times), helped me edit, and made every moment fun. I'm lucky to have her with me in this process ❤️. 4/4

[David Goertsen @DavidGoertsen]

I successfully defended my Ph.D. in Bioengineering last month! @Caltech has been an incredible place to do research and I'm thankful to have learnt so much there. 1/4

[David Goertsen @DavidGoertsen]

I've received an incredible amount of support from my parents. They are both incredibly hardworking and have so much integrity - it was an easy template to follow to become a bioengineer. 3/4

[Claire Bedbrook @clairebedbrook]

Excited to share my first post doc paper! W/ @Ravi__Nath @BrunetLab @KarlDeisseroth & Rahul!! Rapid and precise genome engineering in a naturally short-lived vertebrate https://t.co/RhfXAYCiWg

[Min Jee Jang @minjeejang]

Thrilled to finally share my work at @VivianGradinaru lab at @Caltech - we developed a spatial transcriptomics approach to visualize and quantitatively analyze pooled systemic AAVs (capsids and cargos) in intact tissue across species. 1/n

[Charles Guan @charlesbmi]

Excited to share our latest work! 🎉

Individual-finger brain-computer interface decoding from posterior parietal cortex (PPC). #BCI finger representations resemble that of able-bodied individuals, even years after paralysis. https://t.co/rgpJqBnFp8

#tweetprint 1/n:

[Molecular Therapy Family of Journals @MolTherapy]

Now in @moltherapy Methods & Clinical Development (#MTMCD) from @Caltech researchers: Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the #AAV capsid. https://t.co/SXwI8K3oDL

[David Goertsen @DavidGoertsen]

@titicreus @VivianGradinaru @CapsidaBio Thanks! We characterized expression in the liver (as well as other organs), where there was no difference between AAV9 and AAV9.452sub.LUNG1.

[David Goertsen @DavidGoertsen]

Can directed evolution of the #AAV capsid yield useful lung gene therapy vectors? My paper with @VivianGradinaru at @Caltech, out today in @MolTherapy – Methods and Clinical Development (https://t.co/ufx4ycJQuJ), aims to answer this question. 1/8

[David Goertsen @DavidGoertsen]

I am grateful for the support and mentorship of my advisor @VivianGradinaru and co-authors Nick Goeden and Nick Flytzanis (who both founded @CapsidaBio). I couldn't have done this project without them. 8/8

[David Goertsen @DavidGoertsen]

AAV9.452sub.LUNG1 expands the toolbox for gene delivery to the lung and demonstrates that productive vectors can be made through substitution between AA452-458 of the AAV9 capsid. We have shared the plasmid for AAV9.452sub.LUNG1 on @Addgene: https://t.co/YFgW5AOBr1. 7/8

[David Goertsen @DavidGoertsen]

I'm excited to give the @driverseattalks tomorrow at 9am PST/12pm EST about our recent publication in Nature Neuroscience!

[Driver Seat Talks @driverseattalks]

Back at it! Next week, we welcome David Goertsen (@DavidGoertsen) of the @VivianGradinaru Lab who will take us through his @NatureNeuro paper on engineering specific AAV capsid variants.

Join us on Tuesday 22-March-22 at 17:00h CET!

#OpenScience #ScienceTwitter #neuroscience

[David Goertsen @DavidGoertsen]

@dibidave Funnily enough, I actually use this exact logic to help me overcome fears of failure... Nothing I do can ever end so catastrophically bad that heat death won't ameliorate it.