David Wanderley

Kidney Pathology

[Mayo Clinic Nephrology @MayoClinicNeph]

Drug-Induced Thrombotic Microangiopathy in Cancer

@Mbarbarini @HerrmannMd @asnpublications

https://t.co/va78pMs66l

[Grace Choung, MD 박영이 @grace_choung]

Podocyte and Tubular Vacuolization in Patients Receiving Pegcetacoplan - Kidney International

#renalpath https://t.co/GCfYiu3yzK

[David Wanderley @DavidWanderley]

@grace_choung Here in our laboratory, we’ve seen the same changes in two patients who were also receiving pegcetacoplan. We performed Oil Red O staining and found lipid positivity. We had started writing up our cases for publication, but hadn’t finished the manuscript yet.

[David Wanderley @DavidWanderley]

@arkanalabs Fabry

[Sanjeev Sethi @SethiRenalPath]

Tough case.

LM: granulomatous interstitial nephritis, extensive.
IF: negative.

Look carefully and you start seeing small foci of necrosis in glomeruli, surrounded by inflammation/rupture of Bowman’s capsule.

Dx: 1. Granulomatous interstitial nephritis. 2. Necrotizing glomerulonephritis, pauci-immune. (both possibly drug related).

30-yr woman with rash, serum creatinine 10, bipolar disorder-just started treatment. ANCA, other serology negative.

[Grace Choung, MD 박영이 @grace_choung]

Congenital Anomalies of the kidney and urinary tract: pediatric origins and adult outcomes - Kidney International https://t.co/8I0SI7lIgd

[David Wanderley @DavidWanderley]

@arkanalabs FSGS, NOS. nephrotic syndrome associated?

[Grace Choung, MD 박영이 @grace_choung]

Pathological Diagnostic Criteria for Thrombotic Microangiopathy in the Renal Allograft: Lessons Learned During the Banff Working Group Consensus Process - Kidney Medicine https://t.co/U3wxIUbUxH

[Anthony Chang, MD (張賀文) @ChangUCanSpare]

Enjoy these amazing images from this Toluidine blue stain #renalpath #electronmicroscopy

Courtesy of @hawkssox (first time I've ever seen an actual case of this entity)

[Anthony Chang, MD (張賀文) @ChangUCanSpare]

Most outrageous TBM involvement by fibrillary GN ever. Occurs in 10-15% of cases, but usually not this extensive #renalpath

IgG IF and DNAJB9 IHC

[David Wanderley @DavidWanderley]

@arkanalabs Normal, for me…

[Gian Marco Berti @GianMarcoB65728]

Re-considering Rituximab efficacy in IgA Nephropathy: a new role in patients with crescents?
We explored RTX-based therapy in #IgAN with crescents, showing encouraging signals in proteinuria reduction and relapse prevention.
Great teamwork @Unibo

https://t.co/1IZVlZaHg1

[Salem Almaani @SalemAlmaani]

Our new article Multi-omics of kidney biopsies in ANCA-associated GN:

🔹 Complement activation precedes visible glomerular injury
🔹 Monocytes dominate the infiltrate
🔹 Novel TRIM21/25 axis + noncanonical IFN signaling
🔹 PD-L1 checkpoint failure

https://t.co/NPjTMfB3Fq

[Boonyarit Cheunsuchon, MD @roboonya]

Lipoprotein glomerulopathy in 36 yo F. Glomeruli shows dilated capillary lumens filled with lipoprotein thrombi.

[Gian Marco Berti @GianMarcoB65728]

Our teaching case highlights a novel entity of renal toxicity after combination chemotherapy, emphasizing the diagnostic value of kidney biopsy and clinicopathologic correlation.
@gisellavischini @UniversityofBologna
https://t.co/1nbMK4FS7B

@KidneyMed

[Andreas Kronbichler @AKronbichler]

Our #IWG @ERAkidney work on disease modification in lupus nephritis has just been published in #NRN
https://t.co/H9hwYi8m1X

@IoannisParodis @Lupusreference @smirioglu @LuvacsL @AnnetteBruchfe1 @StefanieSteige6 @sarah_m_moran @OhioStateNeph @KateIsabelle24 et al.

[Arkana Laboratories @arkanalabs]

The arrow points to an intranuclear viral inclusion characteristic of BK virus, one species of non-enveloped dsDNA viruses belonging to the polyoma virus family. Sarah Stewart (see inset), a physician and research scientist, studied viral oncogenesis (she was the first woman to earn an M.D. degree from Georgetown Medical School). Dr. Stewart and her collaborator, Dr. Bernice Eddy (Ph.D. virologist), renamed the parotid tumor virus originally discovered by Ludwik Gross “SE polyoma virus” (the “SE” was for “Stewart-Eddy”). Interestingly, Dr. Stewart like the name “omnioma” virus, but Eddy suggested the term “polyoma” virus since not all viral infections caused tumors in all tested animals. The detailed history of this virus family and its discoverers is chronicled in a fascinating article by Gregory J. Morgan (see below).

References
Morgan GJ. Ludwik Gross, Sarah Stewart, and the 1950s discoveries of Gross murine leukemia virus and polyoma virus. Stud Hist Philos Biol Biomed Sci. 2014 Dec;48 Pt B:200-9. PMID: 25223721.

Photograph of Dr. Sarah Stewart, 1971. Public domain (National Library of Medicine)

#TeachingPoints #kidneypath #renal #pathology

[Arkana Laboratories @arkanalabs]

We're excited to share that @Tiff_Caza, Dr. Frank Boyd, and Dr. Patrick Walker are featured collaborators on a new research publication titled, "Clinical and histologic predictors of non-diabetic kidney disease in patients with diabetes mellitus." 

Read the publication here: https://t.co/xYpHiEdPbT

#renalresearch #kidneyresearch #nephtwitter #pathtwitter #diabetes

[Arkana Laboratories @arkanalabs]

Acellular scanning EM from a biopsy with membranous glomerulonephritis, stage I showing numerous small shallow depressions representing the site of immune complexes which were extracted corresponding to “pinholes” viewed on silver stain.

Photo courtesy of Dr. Stephen Bonsib. #renal #nephropathology

[Arkana Laboratories @arkanalabs]

A sample from the pathology teaching slide set on Lupus Nephritis, jointly prepared by Arkana Laboratories and @goKDIGO. https://t.co/KwXMfV3nTh

#KDIGO #pathology #renal #kidneypath