Wanna know the methods for the
Solid-Phase Heterocycle Synthesis Using Multicomponent Reactions?
Check our last contribution 🥳
@daylinfp@bernis_lab@Daniel_G_Rivera
Many thanks to @upen14 and Prof. Erick V. v d Eycken for the call
https://t.co/dPmA1jgBXz #ScholarAlerts
@LupitaHLinares1@LatinXChem And since 4 and 5 are larger, the interaction with the receptor is even greater, especially the Wan der Waals interactions.
Hi @LatinXChem community. This is my work titled: “Synthesis of three steroidal carbamates with antitumor activity against mouse colon carcinoma CT26WT cells: in vitro and in silico evidences”. I'm looking forward to your questions. #LatinXChem#LXChemOrg#OC046
@LupitaHLinares1@LatinXChem They are active, because structurally they are related to the receptor.They are mainly hydrophobic but they present H-bond donor and acceptor groups that allow interaction between both.
@LupitaHLinares1@LatinXChem Compounds 4 and 5, according to our prediction, show a greater number of interactions with the https://t.co/DdzjOt35xE the case of compound 6, 4 different binding modes were also obtained, which makes their anchorage with the receptor ineffective.
@LupitaHLinares1@LatinXChem Thank you very much! It was not necessary to protect the C-OH, because I used NBS for oxidation, which only oxidizes axial OH and in this case the OH of C-3 is equatorial.
To open the epoxide use HClO4 / THF / H2O, an opening reaction of epoxides in an acid medium.
@OjedaCarralero@LatinXChem Probablemente si. La temperatura de ebullición del CHCl3 no es tan alta,vapor de H2O debe ser suficiente.El ácido se adiciona como catalizador,no debe ser limitante.Quizás como el PhNCO es inestable en condiciones húmedas,puede afectar el rendimiento de la reacción a mayor escala
@daylinfp, your poster submitted to #LatinXChem2021 has been accepted for presentation in the #LXChemOrg category. After the deadline, we'll let you know the registration number and further details. See you on Sept 20!
@KatrinaDeCuba Y hay quienes nos critican por haber optado x vacunas propias. Imaginan el presente y futuro de #Cuba esperando x la "buena de Dios" de los países ricos para vacunarnos vs. #Covid19??
Estuvo claro #FidelPorSiempre, estaba claro nuestro presidente @DiazCanelB.