A big chunk of my Ph.D. work is now online. We try to figure out why many subunits of the TIP60 complex are involved in translocations with the Polycomb group proteins in Sarcomas.
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.
Plant, Bacterial, Archaeal Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please RT 💚
1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance?
We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains.
🧵
https://t.co/h5G9zTXNZz
When my wife and I were going through IVF last year we had a simple question — “We’re 35. To bank embryos for two more kids, how many cycles should we plan for?”
I couldn’t find any good tools to navigate the data (PGT-M would make it even harder) so I made one.
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis or other (non-LCH) histiocytic sarcomas cases.
I'm trying to understand non-surgical chemo and targeted therapy options, new pathology markers to better diagnose subtypes/treatments, and any data on progression in pediatric patients. Please feel free to share – I’m trying to cast a wide net due to the rarity of this condition and how little is known.
People can contact me directly at my first name (as written in my profile) at https://t.co/ubo0zQRMn0.
🧵 1/ We’re excited to share that our new paper with @adrianbracken lab is out 🎉 In this study (which began 10 years ago!) we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇
IIM-Bangalore’s Director publicly disclosed a Dalit professor’s caste in a mass email circulated within the institution, denied him equal opportunities, finds inquiry.
https://t.co/7XwJA5e2Pr
Just received a wonderful Christmas gift from @NIH ! $2.76M to study molecular & cellular changes in the human brain across menopausal transition! 🎉 So excited! We’ll be hiring 2 postdocs-come join us in NYC for cool science, as we transform #WomensMentalHealth research!
In addition to applied statistics, I have another repository on Data visualization: "quick data vis" (https://t.co/87bQt5Ac6z). It used to be under "Online_R_learning" but now has its own repository on GitHub. I have used this content to teach 1st year grad students for 3 years.
🎉Excited to share our new preprint on Biorxiv 🥳
We uncover how RNA Polymerase III (Pol3) dynamically regulates tRNA transcription during heat shock (HS) stress!
So what did we find? 🧵
https://t.co/nXbJElhES6
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It's an absolute scandal and tragedy that India is forced to spend $250m/year to provide access to the latest science to its people. A complete and total failure of global science leadership and of science writ large.
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in @NatureGenet describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment.
https://t.co/0aINMj2MTu
"Menstruation Matters" launches today! Our November Focus explores periods from a multidisciplinary lens, addressing myths, period poverty, and supporting menstrual health across diverse populations. [1/14] https://t.co/3HxQGJH7HD
How does PRC1 counteract transcription?
See this preview from myself and @adrianbracken on a really exciting new study from the @RobKlose lab where they demonstrate that ncPRC1 blocks early stages of transcription activation.
https://t.co/Zn8qY9TzF5
@conwayer1 for title inspo!
Front cover alert 🚨 our research on the mechanics behind a dog's iconic wet nose is featured on the @CurrentBiology cover! Learn how skin growth & blood vessels shape those unique grooves & domes - a must read for biology & physics fans 🐶🔬 @UNIGEnews
https://t.co/lujb59pNDF