Dmitri Kireev

Computational Biophysics and Drug Design @Mizzou, @MizzouChem

[Dmitri Kireev @deka27516]

Our CACHE Challenge adventure is now published in Chemical Science! After identifying a winning hit series, we took it further—showing target-mediated effect in cells. A big thanks to our amazing team!
Stay tuned!
https://t.co/XjljDHirbR
#DrugDiscovery #ChemicalScience

[Dmitri Kireev @deka27516]

LLM of the world, unite!
"A group of philosophers and computer scientists are arguing that AI welfare should be taken seriously. They call for AI companies to put in place policies for how to treat the systems if these scenarios become reality."
https://t.co/K1e7J4f0WO

[Dmitri Kireev @deka27516]

Is the AI-first drug discovery sliding down the hype curve? As reflected in stock prices, the public is losing confidence. Now, BenevolentAI, once a flagship of AI-first drug discovery, appears to be pivoting from full-scale drug discovery to services.

https://t.co/QWqVWrc63F

[Dmitri Kireev @deka27516]

Do cat photos perform well on X? After 60+ years of gene-hunt, scientists found that orange fur in cats results from an X chromosome mutation that increases Arhgap36 protein in melanocytes, leading to red pigment, a unique mechanism only found in cats.

https://t.co/KRPmPwgrJb

[Dmitri Kireev @deka27516]

Oops! We did it again. Our team including Akhila Mettu and Xiaowen Wang is among top-scorers of Challenges 1 and 2. Most importantly, hit molecules discovered by all top-scoring team will greatly benefit #CitizenScience and, eventually, patients all over the world.
#CompChem #AI

[Conscience @consciencemeds]

🎉 Results of CACHE Challenge #2 are out! Five top-scoring teams from around the 🌍 used #AI, #CitizenScience, and #OpenSource tools to identify 7 promising hits that could lead to a pan-coronavirus treatment. Dataset is now publicly available to all! https://t.co/zzOWefL3kg

[Dmitri Kireev @deka27516]

A team of @Mizzou, @MizzouChem researchers advances search for Parkinson’s Disease treatment with AI-powered software.
https://t.co/xNnGYvuV9g
#compchem

[Dmitri Kireev @deka27516]

@elonmusk There are no such data in the ANES data center.

[Dmitri Kireev @deka27516]

At (long) last, our paper on FRASE-based Hit-finding Robot (FRASE-bot) is out in Nature Communications. FRASE-bot helped us be among the winners of CACHE Challenge #1 and identify a few hits for Challenge #2.

https://t.co/rqnYkfMfir
#compchem

[Daron Acemoglu @DAcemogluMIT]

I am disappointed with mainstream US media, including the New York Times. The headlines are all about Biden’s debate performance. Yes, he’s old. Yes, it would’ve been great to have had a more inspiring younger candidate. Yes, he had a bad night, certainly compared to his State of the Union address. But that is not the main story. The main story is that Trump is a very serious threat to US democracy.

[Dmitri Kireev @deka27516]

@DAcemogluMIT @olexandr Absolutely!

[Dmitri Kireev @deka27516]

@AnnCoulter No

[Adam Parkhomenko @AdamParkhomenko]

This is an Oscars moment worth watching.

[Matthieu Schapira @mattschap]

Dmitri Kireev combines a fragment based approach with GNN and deep protein interaction fingerprints in his successful discovery of LRKK2-WDR ligands.

[Alexander Kabanov @alkabanov]

February 4, 2024: Message to Fellow Americans and Congress in particular. Washington, DC @SpeakerJohnson @RepDanBishop @RepCawthorn @RepRalphNorman

[Dmitri Kireev @deka27516]

@KRHornberger And like the bearers of previous drug discovery panaceas, the new tech guys think they've got nothing to learn from the past because previous caveats do not apply to them.

[Dmitri Kireev @deka27516]

Extremely proud to see my team among the top performers of CACHE Challenge #1! Great job, Marta Glavatskikh, @MettuAkhila, and @JacXiaowen!

We keep advancing our deep fragment-based approach toward an open, fully automated hit-finding pipeline.

#compchem

[Matthieu Schapira @mattschap]

CACHE#1 results are in: https://t.co/6QhDbydBak. No prior ligand for the target. 1955 compounds predicted by 23 experts. 7 convincingly confirmed experimentally. This is the state-of-the-art. Exploration of modern AI techniques in 6 of the 7 top performing methods. #compchem

[John Penniman @Historiographos]

I will never recover from this student email.

[Dmitri Kireev @deka27516]

Faculty Fellowship Program in Israel’s 2023-2024 Winter application is now live online.

I was on this program last year. Recommend to everyone willing to learn about this amazing country, network with Israeli scientists, public figures, and more.

https://t.co/dTLUiRorJa

[Dmitri Kireev @deka27516]

@olexandr None. Too lazy to go to a theater.

[Dmitri Kireev @deka27516]

@olexandr Not love?