Diana Lázaro

Postdoct Researcher at the Center for Neurodegenerative Diseases Research, Perelman School of Medicine, UPenn

[Penn Medicine CSO @PennMedCSO]

In a recent perspective out in @NeuroCellPress, @df_lazaro & Virginia Lee (@PennPathLabMed) explore findings on alpha-synuclei (#aSyn) strains + discuss recent discoveries about Lewy bodies’ composition https://t.co/DLCJIkXrlx

[Michael Okun @MichaelOkun]

Kudos to Ryan Reynolds @VancityReynolds for telling the story of his father with Parkinson's disease, and also sharing his pops battle w/ Parkinson's disease psychosis. I feel a teaching moment coming on.
Tips:
Here are few tips I share w/ people in my practice and a few up to date articles/information:
1- review the medication list
2- consider simplifying medications for Parkinson's (sometimes to levodopa only).
3- consider lower doses of Parkinson's medications administered more frequently.
4- check for a urinary track infection.
5- sleep is really important; consider a sleep tracking wearable device and get the total hours of sleep a night to 6-8 hours (if possible).
6- Quetiapine helps more with sleep than with psychosis.
7- Cholinesterase inhibitors help some folks.
8- The safest medications for psychosis once you have considered 1-7 are pimavanserin and clozapine as they, in general, will not worsen the Parkinson's symptoms like other anti-psychotics.
9- Clozapine in the US requires weekly blood monitoring and registration w/ the REMS registry (the Risk Evaluation and Mitigation Strategy program).
More up to date information:
The impact of psychiatric comorbidity on Parkinson's disease outcomes: a systematic review and meta-analysis (@TheLancet Regional Health, 2024)
https://t.co/Eu2b9LRq5A
Comparative Efficacy, Safety, and Acceptability of Pimavanserin and Other Atypical Antipsychotics for Parkinson's Disease Psychosis: Systematic Review and Network Meta-Analysis (J Geriatr Psychiatry Neurol, 2023)
https://t.co/eBVw6muR27
Up to Date Parkinson's psychosis information (diagnosis/treatment) from Parkinson's Foundation:
https://t.co/Qfhe3uJR5U @ParkinsonDotOrg
Michael J Fox Ask the MD Parkinson's and Psychosis:
https://t.co/YCEqRTo3hG @MichaelJFoxOrg #Parkinsons #fixelinstitute #michaelokun

[WPC 2026 @WorldPDCongress]

New WPC Blog Post!

National Plan to End Parkinson's Act Signed Into U.S. Law With Historic Global Significance

by @MichaelJFoxorg

Read More: https://t.co/znjHW8Wcdf

#wpcblog #Parkinsons

[Eddie Lee @TNRLab]

Welcome to Philly!

[WPC 2026 @WorldPDCongress]

New WPC Blog Post.

Unveiling Parkinson's Disease Through The Microscopic Lens

by Diana Lázaro, PhD @df_lazaro

Read here: https://t.co/pbU5fngK3w

WPC Blog made possible with support from @SupernusPharma and @MTPA_US

#Parkinsons @PennMedicine

[Diana Lázaro @df_lazaro]

Check out my latest contribution to the WPC blog! Thank you so much for the invitation!

https://t.co/JdFxO3GmpQ

[Penn Path & Lab Medicine @PennPathLabMed]

Members of our Neuropathology team attended & presented on numerous topics at the 100th annual meeting of @neuropathology last week. #AANP100
Virginia Man-Yee Lee, PhD also received the Award for Meritorious Contributions to Neuropathology, congrats!!
@MacNasrallah @TNRLab

[ShorterLab @ShorterLab]

Navigating through the complexities of synucleinopathies: Insights into pathogenesis, heterogeneity, and future perspectives: https://t.co/uXc9ZCzi5W

[Oded Rechavi @OdedRechavi]

Expansion microscopy is amazing

[Oded Rechavi @OdedRechavi]

The real story being every project that ends up being published

[Rui Costa @ruimcosta]

50 anos, 50 years.

[Van Andel Institute (VAI) @VAInstitute]

We are honored to announce that Dr. Anders Björklund of @lunduniversity will be the recipient of the 2024 Jay Van Andel Award for Outstanding Achievement in Parkinson’s Disease Research!
https://t.co/BAJ8kqfKce

[Diana Lázaro @df_lazaro]

#WorldParkinsonsDay reminds us of the challenges faced by those with this condition. Today, and every day, we stand united in our pursuit of knowledge and innovation, working tirelessly towards a brighter tomorrow for individuals affected by Parkinson's disease.

[The Rainwater Charitable Foundation @RCFNeuro]

Congratulations to Dr. Virginia Man-Yee Lee and Dr. Cristian Lasagna Reeves, winners of the 2024 #RainwaterPrize for their outstanding contributions to neurodegenerative research and advancements in tau understanding.

[AD/PD - Advances in Science & Therapy @adpdnet]

What an incredible Day 2 at #ADPD2024!🤩
Every moment counts – from fascinating sessions in the program to hours spent building important connections with colleagues from around the world – it's all here.
Check out the Day 2 Highlights video and see for yourself 🔽

[Diana Lázaro @df_lazaro]

If yesterday you were at Prof. Tiago Outeiro talk at #ADPD2024 meeting, and you want to dive more into Synphilin-1 role on aSyn assembly, come to the poster #398 😉

[Diana Lázaro @df_lazaro]

If you are at the #ADPD2024 meeting come to poster #399 to learn more about synphilin-1 and how this protein interferes with aSyn biology! I will be there waiting for you 😉

[Diana Lázaro @df_lazaro]

https://t.co/o0iv72q4bJ

[Diana Lázaro @df_lazaro]

@DanielErsk1ne Hi Daniel! I will be there, so I hope we can finally meet in person.

[George J. Netto MD @DrNetto]

We are so proud of our BREAKTHROUGH STARS @PennMedicine and @PennPathLabMed !!!