Divya Krishna Kumar

PhD student at @Barkailab at the Weizmann Institute of Science

[Barkai Lab @BarkaiLab]

(1/8) Still wondering how low complexity intrinsically disordered regions (IDRs) guide transcription factors (TFs) to bind in genomes? Previous studies on sequence grammars; our new @MolCell paper takes the next step: de novo design of functional TF IDRs!
https://t.co/qJugw2V3qE

[Divya Krishna Kumar @Divya_KKumar]

Exciting work! @MindelVladimir @SagieBr

[Barkai Lab @BarkaiLab]

(1/13) Exciting findings from our latest study, now published in @NAR_Open as a breakthrough article! https://t.co/PyrwwbG9kR

[Barkai Lab @BarkaiLab]

New 📄 by @tamar_jana + @SagieBr
We introduce MPBA, a novel method allowing parallel measurement of TF binding to thousands of designed DNA sequences within cells. We use it to answer a fundamental question - how prevalent is TF binding cooperativity. 1/9 https://t.co/XEMgBsRKw3

[Bohdana Hurieva🇺🇦 @bhurieva]

I am super excited to share our new paper in @NAR_Open about all the complex ways of how IDRs regulate the binding patterns of Gln3!🥳🎉

Thank you everyone for such an amazing work together, especially @Divya_KKumar @FJonas15 @BarkaiLab

[Divya Krishna Kumar @Divya_KKumar]

🔥New paper out in @NAR_Open! 🔥

Thrilled to have taken another step towards understanding the role of disordered regions in eukaryotic transcription factor binding specificity

Enjoyed working with the very best @bhurieva @FJonas15 @NaamaBarkai

[Barkai Lab @BarkaiLab]

🎉Happy to share our new paper! Intrinsically disordered regions (IDRs) in transcription factors (TFs) encode for complex binding patterns using diverse sequence grammars and interaction types. (1/9)
https://t.co/FjPshZfYwM
@bhurieva @Divya_KKumar guided by @FJonas15 @NaamaBarkai

[Barkai Lab @BarkaiLab]

Check out our new paper: “Intrinsically disordered regions of the Msn2 transcription factor encode multiple functions using interwoven sequence grammars” published @NAR_Open. The work of @MindelVladimir and @SagieBr. https://t.co/pAvCTMpLkG

[Divya Krishna Kumar @Divya_KKumar]

Amazing work by @OffirLupo @BarkaiLab now online in @CellSystemsCP 🔥

[Barkai Lab @BarkaiLab]

🔥Hot from the oven🔥! Our new paper led by @OffirLupo on the role of TF cooperativity in binding specificity is now out in @CellSystemsCP
see🧵below for highlights (1/10)

@WeizmannScience
https://t.co/qRY5xdQi4c

[FJonas @FJonas15]

Read the newest chapter of the histone timer⏲️arc in our @NAR_Open paper investigating 🧐 the role of different histone chaperones and remodelers using the . Special thanks to Gilad, it was again great working with you👨‍🔬 and the other members of the @BarkaiLab👩‍👧‍👦. (🧵)

[Barkai Lab @BarkaiLab]

New @NAR paper by @FJonas15 & Gilad defining main activities of histone chaperones & chromatin remodelers in nucleosome exchange 🐣

Do they mainly incorporate nucleosomes displaced by transcription? Increase exchange in promoters to enable TF binding?

https://t.co/JhN45KDo9m

[Divya Krishna Kumar @Divya_KKumar]

@chongloi_g @FJonas15 @BarkaiNaama Thank you Grace!

[Divya Krishna Kumar @Divya_KKumar]

🤩Our paper is online! We elucidate the role of IDR rich DBD external regions in directing promoter selection. I had great fun, and learned a great deal working with the best team @FJonas15 and @BarkaiNaama

[Barkai Lab @BarkaiLab]

🥳🎉We are delighted to share our new paper that deciphers the complementary strategies by DNA binding domains (DBDs) and IDRs in directing transcription factor (TF) target specificity. 🎉🥳
https://t.co/SBuCQuV7rM
@Divya_KKumar
@FJonas15
@BarkaiNaama

[Barkai Lab @BarkaiLab]

🥳🎉We are delighted to share our new paper that deciphers the complementary strategies by DNA binding domains (DBDs) and IDRs in directing transcription factor (TF) target specificity. 🎉🥳
https://t.co/SBuCQuV7rM
@Divya_KKumar
@FJonas15
@BarkaiNaama

[Molecular Cell @MolecularCell]

Online Now: Complementary strategies for directing in vivo transcription factor binding through DNA binding domains and intrinsically disordered regions https://t.co/UHFwqzoRD9

[Divya Krishna Kumar @Divya_KKumar]

🤩Our paper is online! We elucidate the role of IDR rich DBD external regions in directing promoter selection. I had great fun, and learned a great deal working with the best team @FJonas15 and @BarkaiNaama

[FJonas @FJonas15]

Proud to present our 🎉new paper🎉deciphering the IIDR grammar of transcription factor target specificity: https://t.co/Gij3ZAG7a2. Special shout out to my fellow code breakers 🕵️ @BennyKrupkin and MiriCarmi and the rest of the @BarkaiLab - follow 🧵 for highlights

[Barkai Lab @BarkaiLab]

Excited to share our newest preprint by @TamarGera @FJonas15 & Roye More: Evolution of binding preferences among whole-genome duplicated transcription factors
https://t.co/GBQBIir4QS
Ever wondered how the transcriptional network evolves? Read more to find out! (1/7)

[Barkai Lab @BarkaiLab]

Our new paper, led by Gilad Yaakov and @FJonas15 just came out! @NatureBiotech
⏱We used molecular timers to measure histone exchange genome-wide. 1/5
https://t.co/M0kDRAvlSZ

[Rahul Roy @rahul_nanobio]

Thanks to support from @CapgeminiIndia @HFSP we have several positions to work on developing new methods/tests and ask challenging questions in infectious diseases. Please RT ! ! https://t.co/4WSGB6wgEn

[T Leela SRINATH @srinath_tl]

We, as citizens of India,
are 'Independent' every day but many of us don't understand it's true meaning.
Unfortunately for many it's 'just' a holiday or a person's birthday to remember once in 365 days.

[Sagie Brodsky @SagieBr]

Excited to share my latest work together with @tamar_jana published today @MolecularCell. We focused on how transcription factors that bind similar motifs in-vitro localize to distinct promoter sets in-vivo. @BarkaiLab @WeizmannScience (1/7) https://t.co/Pfmyo4Oxxb