Dan Iascone 🔬🐌

Postdoc @PennMedicine / developmental neuroscience / new tired dad!

[Dan Iascone 🔬🐌 @dmiascone]

My favorite image I've made so far in my career. Let me know if you want to use these tools and need any help getting started!

[Neuron @NeuroCellPress]

Check this free featured #NeuroResource of an open source software for mapping synapses across whole neurons. An annotated database of >90,000 synapses reveals several scales of synaptic organization & more
https://t.co/W7fK9VXqIN

[Dan Iascone 🔬🐌 @dmiascone]

@IIascone64360 Probably! I feel like there aren't that many of us so we all must be related somehow. I don't know any Robert Iascones though

[Dan Iascone 🔬🐌 @dmiascone]

First work of my postdoc is out today, in PNAS! Tldr, we found that metabolic activity in cancer cells disrupts the molecular clock
https://t.co/Lx70LXPuFK

[Dan Iascone 🔬🐌 @dmiascone]

@paulahyns Thanks Paula!!

[Dan Iascone 🔬🐌 @dmiascone]

@caffeinatedcee Thanks Cynthia!!

[Dan Iascone 🔬🐌 @dmiascone]

@and_villegas1 Thanks Andrés!!

[Dan Iascone 🔬🐌 @dmiascone]

@CLWarriner Thank you Claire!! You know this means we have to catch up now lol

[Paula Haynes @paulahyns]

My sleep-metabolism work with @amitaseh and the Sehgal lab is now out in Nature Neuroscience! 🎉🥳

A neuron–glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis
https://t.co/ttPQduWRkx
1/19

[Anirban Maitra @Aiims1742]

Tremendous metabolic heterogeneity exists in congenic #PancreaticCancer clones isolated from Kras;p53 mice, impacting circadian function.
As an aside, the clones isolated by @BenStanger01 are an invaluable resource for studying tumor heterogeneity across multiple dimensions.

[Dan Iascone 🔬🐌 @dmiascone]

@Aiims1742 @PennMedicine Thank you for reading it!

[bioRxiv @biorxivpreprint]

Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells https://t.co/RVD3uusj8I #bioRxiv

[Kieona Cook @kieonacook]

https://t.co/bpicwyg7O9 Super happy to announce the culmination of a super fun and interesting project! TL;DR we observed an inverse relationship between the metabolic profile and strength of the circadian rhythms in cancer cells; which could aid in therapeutic interventions.

[Dan Iascone 🔬🐌 @dmiascone]

Happy to share the first paper from my postdoc! We studied cancer cells, but fundamentally this story is about how energy production by the cell can impact its sense of time.

Thank you to all the awesome people who contributed!

https://t.co/SEtfCpzrgA

[Dan Iascone 🔬🐌 @dmiascone]

First mantis of the season in my garden!

[Dan Iascone 🔬🐌 @dmiascone]

I have logged back on twitter to post this weird broccoli I'm growing

[Dan Iascone 🔬🐌 @dmiascone]

@xbfeltx 🥰

[Jessica Schwarz @Jess_E_Schwarz]

The Sehgal lab recently had the honor of surprising @amitaseh with her actual @SRBR_Outreach Pioneer Award in person! We (past and present) are lucky to have Amita as our mentor.
https://t.co/N7ganR5UMU

[bioRxiv @biorxivpreprint]

BigNeuron: A resource to benchmark and predict best-performing algorithms for automated reconstruction of neuronal morphology https://t.co/gUx7YVQN1i #bioRxiv

[Dan Iascone 🔬🐌 @dmiascone]

@xbfeltx :(

[Justin O'Hare @JustinKOHare]

How do single neurons integrate thousands of inputs, from multiple circuits, to learn about the environment?

Out today in @ScienceMagazine , we bring subcellular resolution to this question. Punchline: intracellular Ca²⁺ release plays a big role!

https://t.co/cHy01frI5K