Donald

[Dr Singularity @Dr_Singularity]

Decades of Age Damage Reversed by New Enzyme

Researchers engineered CMLase, an enzyme that removes advanced glycation end products (AGEs), a form of age related protein damage long believed to be irreversible.

In laboratory tests on aged human tissues, it reduced AGE damage by over 70% in arteries from a 75 year old donor and lowered damage in elderly skin to below the levels seen in 31 year old skin.

[Linus Petersson @LinusPeters]

How many people have you heard advocating for radical life extension publicly?

It’s still fringe. But doesn’t have to be!

Longevity advocacy is super important

Speak up: Life is good. Death is bad

[Donald @Donald1010064]

@WSJ Who's gonna mass market defender robots to protect the people from a tyrannical government?

[Donald @Donald1010064]

@freeCodeCamp Walk up to a chick at a bar: yeah I do cryptography... No biggie I'm not smart there's waaaay more smart people than me y'know... Ok I'm smart wanna fk

[Donald @Donald1010064]

@Jivesh1995 @shinobi602 Marathon super underrated

[Donald @Donald1010064]

@PhysInHistory I wish I could take naps. My mind literally says "aw hell naw we ain't bout this relaxing bs"

[Donald @Donald1010064]

@foundmyfitness Can I just take some oxytocin supplements instead lol

[Dr. Rhonda Patrick @foundmyfitness]

Oxytocin is more than the “cuddle hormone.” It may be a key regulator of aging and longevity.

We've long known about oxytocin's role in translating social experiences into physiological health and stress resilience. New research identifies the biological mechanism.

Oxytocin levels decline with age, leading to epigenetic remodeling, mitochondrial dysfunction, and chronic inflammation. Restoring oxytocin levels reverses these changes.

This points to a profound idea: cultivating strong social ties throughout adulthood can mitigate this loss of oxytocin signaling and promote robust health and resilience against stress and disease.

As sterile-sounding as it might seem, it's a strong argument to think about intimate bonds and social interactions as pro-longevity interventions. They're not optional.

[Harshi Peiris, Ph.D. @Neuroscope_mp]

BREAKING: The FDA just approved the first human trial of gene therapy designed to reverse aging

Life Biosciences will use partial epigenetic reprogramming (3 Yamanaka factors) to "reset" cells to a younger state—without changing DNA

Historic breakthrough for longevity 🧬
https://t.co/x1aFYCf699

[Sam Bent @DoingFedTime]

One column reads like a bank statement for the surveillance state,
the other reads like none of your business.

[Next Science @NextScience]

🫀 Israeli researchers 3D-printed the world’s first vascularized heart using a patient’s own cells and biological materials.

Israeli scientists at Tel Aviv University have achieved a historic first by 3D-printing an entire vascularized heart using human cells and biological materials. Unlike previous attempts that focused only on scaffolding or lacked cellular structures, this miniature organ—roughly the size of a rabbit's heart—contains blood vessels, chambers, and the complex architecture necessary for cardiac function. The team utilized a "bioink" derived from a patient's own fatty tissue, which was processed into stem cells and then differentiated into heart and vascular cells. This personalized approach significantly minimizes the risk of organ rejection, as the material is biologically identical to the recipient's own body.

While the heart does not yet beat and requires further development to handle high-pressure blood flow, researchers believe this proof-of-concept could revolutionize how we treat heart failure. Currently, thousands of patients die annually while awaiting organ transplants due to a critical shortage of donors. The ultimate goal is to scale this technology to create full-sized, functional human hearts that can be "printed" on demand in hospitals. If technical hurdles such as structural stability and cellular synchronization are overcome, scientists estimate that routine organ printing could become a reality within the next decade, fundamentally altering the landscape of cardiovascular medicine.

Source: Freeman, D.. Scientists create world's first 3D-printed heart using human cells. NBC News MACH.

[Linus Petersson @LinusPeters]

Aging is a DIS-EASE! - Sign the Petition! https://t.co/eQxNGh4Aqx via @Change

[Aubrey de Grey @aubreydegrey]

The pro-aging trance is alive and well. But for how long?

[Elite Man @EliteMan091]

@cryptorover China has banned crypto many times before, but this time it seems a little harsher. They are afraid of decentralized currency because they can't control it. This proves why Bitcoin is necessary, it's the only way to escape government surveillance.

[Aubrey de Grey @aubreydegrey]

Fantastic that this is out! Please have a look. This was a huge advance for cryonics, and now that it's published I am sure it will lead to much more widespread adoption of intermediate-temperature storage. (Full disclosure - I am now married to the patient's widow :-))

[Aubrey de Grey @aubreydegrey]

Outstanding interview with George Church, one of the foremost superheroes of the longevity movement: https://t.co/Gr9c5yur0L

[Aubrey de Grey @aubreydegrey]

Interesting... Musk seems to be thinking SLIGHTLY more about aging than in the past. See the ten minutes of this starting at 51:30. https://t.co/f5tmWuaCxS

[Hex Conference @hexconference]

6th Annual HEX Conference [Day 3—Hour 2] with @aubreydegrey discussing his progress on longevity research and ongoing fundraising (in and out of crypto). https://t.co/chNe6CnpnT

[Roney Laurent @roneylaurent]

1/
$AUBRAI is an incredible tool — the "AlphaFold moment" for longevity has arrived. A bioagent and digital twin from @aubreydegrey in collab with @vitadao for longevity research.

I decided to take a deeper look into @Aubrai_ for love!

...🧵