Dougan Lab

Regulated proteolysis | N-degron | AAA+ machines | #Proteostasis views my own

[Molecular Cell @MolecularCell]

Online Now: Design principles of a membrane-spanning ubiquitin ligase https://t.co/4Gqc287NpC

[Dougan Lab @DouganLab]

A C-degron regulates Chk1 kinase by allowing stability of inactive Chk1 and by making it short- lived upon activation | PNAS https://t.co/ggOc8bSyIh

[Dougan Lab @DouganLab]

Molecular mechanisms of mitochondrial AAA+ proteases - Journal of Biological Chemistry https://t.co/tRmNOf5auw

[Dougan Lab @DouganLab]

Chemical activation of mitophagy via the N-degron pathway alleviates mitochondrial neuropathies https://t.co/1X9CrevtK4

[Guillaume Laconde @Glaconde34]

Data-Driven Design of PROTAC Linkers to Improve PROTAC Cell Membrane Permeability | JACS Au https://t.co/0Ybh7kr1CI

[Dougan Lab @DouganLab]

Molecular mechanisms of mitochondrial AAA+ proteases - Journal of Biological Chemistry https://t.co/tRmNOf5auw

[Hema Chandra Kotamarthi @HemaKotamarthi]

Our recent work on mechanism of disassembly and reassembly of oligomeric proteins is now published in ACS Biochemistry.
https://t.co/swlKg7GMpg

[Dougan Lab @DouganLab]

CLIP-LUX: A Luminescent Split-Ubiquitin Assay Using ClpS-Mediated N-Degron Recognition for Detection of Protein-Protein Interactions in Mammalian Cells. https://t.co/q4dgRhSWrS

[Dougan Lab @DouganLab]

Elongation Factor Tu Acts as a Chaperone to Activate an Antibacterial RNase Toxin - https://t.co/VopfnlQgBo #ScholarAlerts

[Molecular Cell @MolecularCell]

Online Now: Mitochondria as sources and targets of cellular signaling https://t.co/LFadRnFIhD

[ShorterLab @ShorterLab]

Metabolically regulated proteasome supramolecular organization in situ: Cell https://t.co/uE5hgU773y

[Molecular Cell @MolecularCell]

Online Now: Ribosome-NAC collaboration: A regulatory platform for cotranslational chaperones, enzymes, and targeting factors https://t.co/fMaLmcskd1

[Dougan Lab @DouganLab]

The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis https://t.co/7tOn7MTmOg

[ShorterLab @ShorterLab]

In @eLife: Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (PROTAC) https://t.co/KF9kQCD3Ap

[ShorterLab @ShorterLab]

Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1: https://t.co/JOA60jIP1m

[MITOtalks @MitOtalks]

How's your juggling act? Mitochondria also have one, and the MITOtalk this week will be all about it.
See you there?

[Dougan Lab @DouganLab]

Mechanisms of assembly and function of the Hsp70-Hsp40 chaperone machinery
https://t.co/WepoHudBeb

[Molecular Cell @MolecularCell]

Online Now: Delayed protein translocation protects mitochondria against toxic CAT-tailed proteins https://t.co/9CXhFvQ4Ck

[Cameron Thrash @jcamthrash]

Proteolytically activated antibacterial toxins inhibit the growth of diverse gram-positive bacteria https://t.co/os0HRbZdDi

[Cell Biology J-Club @cell_club]

The yeast peroxisomal proteome at absolute quantitative scale https://t.co/fYhvjiBLVB