In a double-blind, randomized phase 2 #clinicaltrial, treatment of patients with #heartfailure with preserved ejection fraction (HFpEF) with the oral anti-fibrotic agent pirfenidone reduced myocardial fibrosis. #NMEDClinical@NWhearts@OfficialUoM https://t.co/Y8PYULQznj
Pirfenidone effectively reduced myocardial fibrosis in patients with #HFpEF based on findings from the PIROUETTE trial presented during #ACC21, suggesting #fibrosis might be an effective treatment target. Read more: https://t.co/xiOTVVCAk0
For whoever needs it, this little gem from Miss 11-
'The teacher said I seemed quiet today... like I wasn't blooming. I said I'm fine Miss X. I'm just working on growing roots today instead of flowers'.β€
Hugs to everyone who is having a 'roots not flowers' day β€π±.
@Everton Aged 10, sat in the Anfield Road end with my Dad and brother (both reds), watching those 2 goals...one of the best days ever for a young blue!
@DoctorChrisVT Re. Statistics: estimated efficacy between dose 1 and 2 is 52% (95% CI 29.5-68.4); estimated efficacy between day 15-21 is 89% (95% CI 52-97%). These are estimated rates of efficacy, with small numbers of outcome events, hence wide confidence intervals = lots on uncertainty here.
@doctor_oxford A national health policy based on a small, non pre-specified, exploratory analysis, with confidence intervals wider than the sky, is astonishing!
https://t.co/YBCuETj8ht Iβm no vaccine expert, but Dr Fauci is.
I have to implement EBM for patients but Iβm not to receive that same EBM? I signed up to 2 doses of a vaccine 3 weeks apart and not to clinical trial of another regime without either ethical approval or my consent.
Covid-19 vaccine gratefully received! Thank you to all the scientists and researchers who have made this possible, and to my colleagues @TheCountessNHS working to deliver this to frontline NHS staff!