Hakeem Yusuff

Cardiothoracic anaesthetist and intensivist /ECMO/Echo/teaching/ Research lead @glenfield_aicu. Honorary senior lecturer @uniofleicester co-chair @PRORVnet

[EuroELSO @EuroELSO]

📢 When RV fails: recognition and #ECLS strategies across critical illness, #EuroELSOwebinar
🫁The failing RV in severe respiratory failure & role of #ECMO
🫀Mechanical support for the failing RV in cardiac disease
📆 April 30 2026, 16:00 CET
Register! 🖋 https://t.co/0yuN2zwuDM

[Society of Mechanical Ventilation @OfVentilation]

Final reminder, if you haven't already done it, can you please help those group of researchers by filling there survey?
Thank you
https://t.co/JDsIWmV3TP

[Critical Care Reviews @CritCareReviews]

Interesting trial result, ahead of ANDROMEDA-SHOCK 2 in a fortnight

Targeted Tissue Perfusion vs Macrocirculatory-Guided Standard Care in Patients With Septic Shock: - The TARTARE-2S RCT

CCR Journal Watch
https://t.co/Sp06oA6IDG

[Waqas Akhtar @DrWaqasAkhtar]

British societies guideline on management of emergencies in patients on ECMO

🫀Recognition of cardiac arrest
🏥 Team structure
🕵️ Early troubleshooting

@BritishCardioSo @FICMNews @ICS_updates @BACCNUK @SCTSUK @BSHeartFailure @ResusCouncilUK @ACTACCUK

https://t.co/oGllN3rgHI

[Vasileios Zochios @vaszochios]

📣Our new PRORVnet collaborative publication (CCR) is out in AJRCCM 🫁🫀

'RV Hemodynamics in ARDS: Monitoring and Implications for Clinical Management'

@ATSBlueEditor, #Douglas Slobod, @drhaty, @MadsDam_MD, @DenaultAndre, @prorvnet

 https://t.co/eDRrppytjP

[M Velia Antonini @FOAMecmo]

Long-term outcomes after VA #ECMO in adults
🔍 multicenter @anzics study investigating incidence of death or new disability at 12 months after VA #ECLS initiation in 🇦🇺 & 🇳🇿
At 12 months 30% pts alive without new disability. Major burden of disability appears to develop in first 6 months
⚖️ different outcome associated with reason for ECLS
⚖️ at 12 months (vs 6) more pts independent in AdL (62.1% vs 48.2%), fewer unemployed due to health reasons (32.7% vs 47.4%)
🖇️ https://t.co/M99oFhhShQ

[M Velia Antonini @FOAMecmo]

Anticoagulation in #ECMO: how to reduce bleedings?
🔍prospective cohort study including 277 adults on #ECLS
🩸risk of hemorrhagic events 2.97-fold higher in patients with a PTT > 70 vs patients under no UFH therapy
Association observed between target PTT & hemorrhagic complications, with risk higher when maintaining PTT values greater than 70". Lower PTT targets may reduce hemorrhages without increasing risk of thrombotic complications.
@asaiojournal #FOAMcc #FOAMecmo
🔓 https://t.co/DFbwIfOpvq

[M Velia Antonini @FOAMecmo]

Veno-pulmonary #ECLS? carefully managed to avoid negative hemodynamic impact!
🩸elevated EBF increase mPAP/LAP & reduce PA pulsatility potentially leading to complications such pulmonary hemorrhage + permanent vasculature damage: hemodynamic response should be considered when selecting or titrating EBF
🫁🫀effect vary significantly depending on RV function. Consider RV injury severity & corresponding afterload, to maintain stability + prevent lung complications.
@asaiojournal
🖇️ https://t.co/kBtkH3waoN

[M Velia Antonini @FOAMecmo]

Initiation of #ECPR in patients presenting with out-of-hospital cardiac arrest? Emergent mechanical circulatory support with VA #ECLS offers a bridge to diagnostic & therapeutic interventions, but can be challenging to provide in a timely fashion.
🔍 55 OHCA patients received ECPR after presenting to ED of large 🇺🇸 academic medical center with active #MCS + cardiac #transplantation program
🗓️ May 2013 to December 2022
🏥 increase in survival to hospital discharge from 22% to 52%
🧠 69% of those discharged had favourable neurologic function (CPC 1-2)
Organizing & implementing a multidisciplinary dedicated #ECMO response team & ECPR program for OHCA, coordinating institutional resources, may improve survival + increase number of runs in OHCA patients.
🔗 https://t.co/wHBEjwn2hB

[Katie Wiskar @katiewiskar]

Non-invasive positive pressure ventilation - BiPAP and CPAP, for example - can be a bit of a black box to most of us ⬛️

Once it's started, the nuances of how to adjust it to optimize each patient's physiology takes skill.

In the wise words of @iceman_ex - "The goal is to titrate PEEP to the triad of best compliance, best oxygenation, and best RV function" 🫁🫀

[Hakeem Yusuff @drhaty]

@InflamAge_UoB @drdhruvparekh @uhbtrust @unibirmingham @unibirm_CMH @BHPComms @BirminghamBRC @ECMCBham @BacrUob Congratulations @drdhruvparekh really well deserved.

[Sung-Min Cho @csmfisher]

Lung injury in myocardial infarction-associated cardiogenic shock supported by venoarterial extracorporeal membrane oxygenation: a scoping review https://t.co/XJ3z9Z6GVc

[veerappan @veerappan91050]

Exciting opportunity alert! 🌟 Join us in Manchester on April 24&25, 2025, for the 14th Ultrasound in Acute Care event. Learn basic to intermediate US techniques from leading pioneers in the field. @iceman_ex @icmteaching @Assoc_Anaes @FICMNews @RCollEM @IM_Crit_ @RCollEM @CC_3N

[M Velia Antonini @FOAMecmo]

Right ventricular Injury in patients with in respiratory failure receiving VV #ECMO
🔍 scoping review aimed to map current literature & guide research on definition & management
📚 30 studies reported on RVI (dilation, dysfunction, failure)
📚 23 studies reported on (heterogeneous) definition, including #echocardiographic indices of RV function/dimensions
📚 13 studies reported on management, including VP & VA ECMO, positive inotropes, pulmonary vasodilators, ultra-lung-protective MV, PEEP optimization
Despite high incidence & strong association with mortality, review highlights scarcity/heterogeneity in studies investigating modalities, criteria for diagnosis, therapeutic strategies for RVI during during VV #ECLS
@asaiojournal
🔗 https://t.co/SDqP0oAM58

📚 Review informed Delphi study by PRORVnet study providing related expert position statements
#FOAMcc on @yourICM
🔓 https://t.co/IYBm5SIgEy

[EuroELSO @EuroELSO]

💉 Sedation practices in adult patients with severe #ARDS on extracorporeal respiratory support using VV #ECMO: if you are an ECMO physician provider don't miss the opportunity to join this survey!
🔗 https://t.co/sWu3glZwGO
⏱️ takes 9' to complete.
🗓️ deadline: January 21, 2025.

[IMCrit @IM_Crit_]

If you need a refresher on Swan-Ganz catheters and PA pressures, this is good. Actually, I am lying. It is VERY good...

Thank you Matt, Sergio, Max et al!

[M Velia Antonini @FOAMecmo]

Development of novel VA #ECMO drainage cannula
⚙️ fluid dynamics #simulation
🔍 ex vivo evaluation
🩸hemolysis assay
🩸PLT activation & receptor shedding
🩸degradation of vW factor multimers
🩸clot volume analysis within cannulae
@asaiojournal
🔗 https://t.co/RrAngDHNs6

[M Velia Antonini @FOAMecmo]

Use of extracorporeal blood purification therapies in #sepsis/septic shock
🧫 rationale & available clinical evidence supporting use of: #RRT, plasma exchange & coupled plasma filtration + adsorption, hemoadsorption
🩺 considerations for current clinical practice
🔍 (future) research: heterogeneity of populations & therapies dosing/timing, endpoints
Integration of additional therapies within treatment protocols can optimize care/improve outcomes, but these must be applied at correct time/dose, taking into account their impact on drugs (eg ABTs). Era of “one size fits all” is over: time has come for paradigm shift toward more focused/personalized approaches in clinical practice/research.
Open access #FOAMcc on @Crit_Care
🔓 https://t.co/tn29Z7eOaO

[M Velia Antonini @FOAMecmo]

Permissive hypercapnia in acute severe respiratory failure: should we target PaCO2, pH or both?? Safe thresholds in critically ill?
🩺mechanisms & management of hypercapnia requiring IMV
🫁 impact of hypercapnia on outcomes
🫁 🫀🧠significant physiological effects: RV & pulmonary circulation, brain & other organs
Hypercapnic acidemia during lung-protective MV may have significant consequences, and perhaps should not be a goal per se, but prompt early consideration of adjunctive therapies. Open access #FOAMcc
🔓 https://t.co/9XnMnu5TzW

[Journal of Cardiothoracic and Vascular Anesthesia @JCVAonline]

Modified CALS including rescue-focused cardiac ultrasound and early institution of extracorporeal cardiopulmonary resuscitation instead of chest reopening.#ECMO #CALS #Cardiacarrest
https://t.co/YZL4zGzIVl