Honsworth

PhD
🇬🇧🇭🇰 🧑🏻‍🔬 in 🇨🇭
Proud Cantabrigian
Avid photographer
Nap enthusiast
CEO, Honsworth Tours
Bünzli
Passionate about 🥩📷🧬🧳⚽️😴🏔🍷❄️
Personal acc

[Honsworth @drhonsworth]

Very pleased to share our new story on SMC complexes, a great team effort from @RoisneHamelin_F, Taschner in the Gruber Lab and James of @DNA_topology. We find that SMC hinge domains are ssDNA gates to facilitate selective obstacle bypass during DNA loop extrusion!

[Honsworth @drhonsworth]

nice mate!

[Morgan Jones @mljones1993]

Great new work from the very talented Emma Fletcher (@Yeeles_Lab). Biochemistry, and a touch of cryoEM, reveal why the DNA replication machinery needs a dedicated leading strand PCNA clamp loader. 🧬🧪🥼🔬🧑‍🔬

https://t.co/9tqrYZqlNc

[Honsworth @drhonsworth]

@hammam_antar @RoisneHamelin_F @DNA_topology Cheers bruv!

[Honsworth @drhonsworth]

Very pleased to share our new story on SMC complexes, a great team effort from @RoisneHamelin_F, Taschner in the Gruber Lab and James of @DNA_topology. We find that SMC hinge domains are ssDNA gates to facilitate selective obstacle bypass during DNA loop extrusion!

[Florian Roisné-Hamelin @RoisneHamelin_F]

Happy to share our last work. Wadjet-I SMC hinges are gates allowing selective bypass of obstacles connected through ssDNA BUT are dispensable for extrusion of naked DNA.
Great teamwork with @drhonsworth, Taschi at Gruber lab with James & @DNA_topology

https://t.co/tVdplsViUl

[Honsworth @drhonsworth]

Check it out here. Featuring of course ecJET ✈️
https://t.co/0rikCwz852

[bioRxiv Molecular Biology @biorxiv_molbio]

The SMC Hinge is a Selective Gate for Obstacle Bypass https://t.co/rH0o2dzRqQ #biorxiv_molbio

[bioRxiv Microbiology @biorxiv_micrbio]

Structure and Activation Mechanism of a Lamassu Phage Defence System https://t.co/cd1hsHgGkH #biorxiv_micrbio

[Honsworth @drhonsworth]

Happy to be part of this fantastic collaboration between the Gruber, Blokesch and Szczelkun Labs to elucidate the activation mechanism of the Lamassu defence system, all spearheaded by the brilliant @liyan19871127
with her beautiful structures! Teamwork makes the dream work!

[Yan LI @liyan19871127]

Glad to share our new preprint, structure of the recently discovered Lamassu bacterial defense system, which is related to Rad50/Mre11 (RM). Our study reveals how Lamassu stays sequestered and activated after phage infection.

[Yan LI @liyan19871127]

Glad to share our new preprint, structure of the recently discovered Lamassu bacterial defense system, which is related to Rad50/Mre11 (RM). Our study reveals how Lamassu stays sequestered and activated after phage infection.

[Honsworth @drhonsworth]

Happy to have helped out on this!

[Florian Roisné-Hamelin @RoisneHamelin_F]

Happy to share our latest work. We characterize a type II Wadjet at Gruber lab and @DCI_EM with @drhonsworth , revealing unique traits—including a tandem KITE subunit, distinct coiled coil organization and a deviant hinge

https://t.co/MUNcmRYXgE

[Florian Roisné-Hamelin @RoisneHamelin_F]

Happy to share our latest work. We characterize a type II Wadjet at Gruber lab and @DCI_EM with @drhonsworth , revealing unique traits—including a tandem KITE subunit, distinct coiled coil organization and a deviant hinge

https://t.co/MUNcmRYXgE

[Honsworth @drhonsworth]

Cool to see some of my PhD work featured in this review (what a blast from the past!)

[Molecular Cell @MolecularCell]

A tale of two strands: Decoding chromatin replication through strand-specific sequencing https://t.co/KAEhQ0IDLp

[Molecular Cell @MolecularCell]

Nucleic acid recognition during prokaryotic immunity https://t.co/dCCDcTMfsH

[Christian F. Baca @ChristianF_Baca]

Very happy to share our new review in @MolecularCell covering nucleic acid recognition and effector mechanisms for various prokaryotic immune systems! Was a great experience creating this with @MarraffiniLab!

https://t.co/f1kKf3qMto

[Honsworth @drhonsworth]

Spent the weekend up in the #Brévine Valley with a notoriously cold microclimate to get my "snow fix". Was expecting some cold but certainly not -31C cold! Apparently lowest temp in 10+ years. As us Brits would say, "it's absolutely baltic out there!"

[MétéoSuisse @meteosuisse]

Il a fait froid cette nuit en Suisse et même très froid à la Brévine avec une température minimale nocturne de -31.1 °C !

[Honsworth @drhonsworth]

Super proud to present Colours of Lac Léman 2024! Back for another year with almost 400 shots of the lake and the Muveran Massif (this time with alignment :D) from my balcony. Watch how the colours and seasonal mood change through the year. #bettereveryloop #lacleman #lausanne

[Kelvin O johnson @_OKJ__]

randomly stumbled upon a YouTube video this morning explaining this new discovery,so I came on Twitter to search for it to see what cosmologists are saying about it.for anyone who does not want to read the paper or this long thread I’m quoting,I’ll try and simplify below.A THREAD

[Nick Desnoyer @NickDesnoyer]

In one year, I genetically engineered the boring Arabidopsis into a beautiful ornamental flower 🧬🌹

Here is how and why I gave this model organism a visual upgrade 🧵(1/7)

[Nicholas M. I. Taylor Lab @NMITaylorLab]

Very happy our paper on Zorya anti-phage defense system is now published in
@Nature! 🥳 Big congrats to first authors
@HaidaiHu and @__jphilipp and all other authors! Wonderful collab with @Salmo_Lab
and @SimonJacksonNZ #cryoEM @UCPH_CPR @koebenhavns_uni https://t.co/AFPSKH14Za