Yeeles Lab

We’re a lab based at @MRC_LMB in Cambridge using biochemistry and structural biology to understand how DNA replication works 🧬

[Tom Deegan @TDDeego]

Great first day of EMBL DNA replication meeting in beautiful Heidelberg, including a hike to the Schloss with @Yeeles_Lab

[Yeeles Lab @Yeeles_Lab]

Amazing talk from @JohannJRoske at the #LMB lab talks! Thanks to @this_clockwork for bringing the replisome to life 🧬🧬🧬

[Harry Orrin @HarryOrrin]

Excited for the first day of the UK DNA Replication Meeting 2024! First up: all things initiation. @BiochemSoc #BiochemEvent

[Yeeles Lab @Yeeles_Lab]

🚨📣 Excited to share our latest work investigating how the replisome responds to topoisomerase-DNA crosslinks 🧬🔬

https://t.co/9ujCs1k8g5

Fantastic work from @rosewesthorpe and @JohannJRoske 🍄🍄🍄🍄

[Yeeles Lab @Yeeles_Lab]

We are excited to share new mechanistic insights into DNA replication fidelity! How does human DNA Polymerase Epsilon recognise and proofread errors made during synthesis? 🧬
Read @NatureSMB https://t.co/ZjkYugQaaq

[Clockwork @this_clockwork]

Here's a render of a full eukaryotic replisome carrying out DNA replication. This was built using real .pdb data from @buildmodels

I used this to make my latest video: (https://t.co/zh2ImuLsOP)

But now I want to do a quick works cited 🧵 (1/ ?)

[Tom Deegan @TDDeego]

New paper from my group, in which we use the combined power of AlphaFold and biochemical reconstitution to determine how the Rrm3 helicase is targetted to the eukaryotic replisome

https://t.co/r6cdK9VvkD

[Yeeles Lab @Yeeles_Lab]

Brilliant to see our talented postdoc, Cristian, publish his work on CMG disassembly in @embojournal. The culmination of his PhD work in the Labib lab at @dundeeuni. @TDDeego

https://t.co/vRMG6CmLso..

[Tom Deegan @TDDeego]

Join us next year for the 2nd edition of the UK DNA replication meeting in Cambridge. The first meeting was fantastic so be sure not to miss out! @Yeeles_Lab @AgaGambus @saponaro_m

https://t.co/V0N1zRF31w

[Yeeles Lab @Yeeles_Lab]

@TDDeego @mljones1993 Does a tuna sandwich count?

[Yeeles Lab @Yeeles_Lab]

Happy 30th Birthday to one of our favourite structural biologists @mljones1993 🥳🥳

[Yeeles Lab @Yeeles_Lab]

Having fun at Cold Spring Harbor! @mljones1993 #cshldnarep #renaissanceman #howdoyoueatlobster

[Yeeles Lab @Yeeles_Lab]

So excited to have arrived at @cshlmeetings Eukaryotic DNA Replication and Genome Maintenance!! Can’t wait to hear all of the amazing science and catch up with old and new friends 🧬 #cshl

[John Diffley @DiffleyLab]

Hi all. Two fully funded four year postdoc positions to study DNA replication initiation using human proteins. Please check out the ad and contact me if you want more info. Closing 30 September.

https://t.co/YcCRlRTo1l

https://t.co/BQTCyG2T1i

[Molecular Cell @MolecularCell]

Online Now: How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication https://t.co/6sbubBgRoO

[Yeeles Lab @Yeeles_Lab]

Very happy and excited to share our latest work on Pol α-primase recruitment to the eukaryotic replisome! 🧬 ⬇️ #dnareplication #cryoEM #biochemistry

[Morgan Jones @mljones1993]

🔬📚 Very excited to share our new paper titled "How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication"! 🧬 A #tweetorial below ⬇️ @MolecularCell @Yeeles_lab
#ScienceTwitter #cryoEM #replication #DNA #polymerase #primase #MolecularBiology #replisome

[Patrycja Kozik @patrycja_kozik]

Our work on perforin-2, a pore-forming protein expressed by #DendriticCells to deliver antigens into the cytosol during #CrossPresentation is now out in
@ScienceMagazine
https://t.co/ZdFoAyFQR2…

Huge amount of work from Pablo, in collaboration with
@laub_marco & @Pati_Krawczyk

[Yeeles Lab @Yeeles_Lab]

Come along to extract DNA from bananas with the Yeeles lab!