Deciphering molecular mechanisms of genome instability in human cells and yeast. Bloom syndrome & BLM, DNA replication & repair, disordered protein function.
The USF Health Morsani College of Medicine is the highest ranked medical school in the country and the only school to receive a perfect score of 100 in a new Medical Excellence Index ranking released Wednesday by a national medical policy group. Learn more: https://t.co/QZBnnqIlK6 @USFHealthMed
🍂The 2025 Fall Session of GIIN webinars is here!
Join us on the 1st Tuesday of each month at 5 PM CET (Rome) / 11 AM DET (NYC). No pre-registration needed, just click to join via Zoom: https://t.co/Aaml0MnmGS
Subscribe here for webinar reminders: https://t.co/PbZafRcKkp
In our latest paper, we uncover condensin II as a novel BLM interactor critical for genome stability in S phase. Condensin II contributes to BLM localization at active forks and undergoes a transient structural change in S phase.https://t.co/rHRyRFtMC9
BREAKING NEWS: The @USFHealth Morsani College of Medicine is the #1 medical school in Florida — and the only program in the state to earn a Tier 1 ranking from @usnews. This places @USouthFlorida among the Top 16 medical schools nationwide.🤘#GoBulls
➡️ https://t.co/vWmKHeIfZI
Our new preprint is now on bioRxiv! 📄 We introduce qAID, an AI-based workflow for automated analysis of DNA replication dynamics. Glad to have contributed a small part to this study.
Osteosarcoma, an aggressive bone cancer, most commonly affects children and young adults.
New research solves the mystery of what drives the genomic rearrangements causing the aggressive development and evolution of osteosarcoma tumours.
https://t.co/vjVofFL63p
RAD52 dominates DNA repair at #centromeres over RAD51 & NHEJ's factors, leading to apoptotic cell death. Centromeric DSBs reveal nuanced repair pathway choices. #genomics#research PMID:39360606, Nucleic Acids Res 2024, @NAR_Open https://t.co/h5faeqcszW
2/2 To learn more about our lab see our homepage: https://t.co/F4xo3RRGzx
We are an international, multidisciplinary lab focussed on genome stability maintenance & 3D chromatin.
Happy to be contacted with any questions you might have about this job. / Fena
1/2 We’re hiring a Postdoc to join us at the University of Copenhagen. Are you fascinated by 3D chromatin function and super-resolution microscopy? Then this might be the job for you. Start date 1st of April 2025, starting salary 4700 Euro/month. https://t.co/Rh85YBw0I0
📣 Excited to share our latest review on 53BP1’s function in replication stress, its role in fork protection, and the significance of 53BP1 nuclear bodies in this context!
https://t.co/TnaMZWUEP4
Our study on how the human MCM2-7 helicase is loaded onto replication origins 🧬 is now online @Nature! 🎉
Our findings reveal that unlike in yeast, human MCM loading does not require ORC6 and can occur through multiple pathways.
Read more here: https://t.co/bPT5Y4uPkR
Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳
Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! https://t.co/D13VcIXABT
The spindle assembly checkpoint in #yeast has been implicated in promoting large chromosomal arrangements, which can cause cancer.
A new #GENETICS study revisits this observation, finding it originated from an experimental artifact & does not hold true.
https://t.co/WcZGqLuksx
Assistant and Associate Professor positions available at UPENN's Basser Center for BRCA . Great opportunity to be part of an amazing scientific environment.
Assistant Level: https://t.co/U15zUBg2le
Associate Level : https://t.co/UyCDhdhmnA
Thrilled to share our new work @biorxivpreprint:
https://t.co/6unXV2pn2C
Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live cells. We reveal genome chromatin is essentially replicated from regions with greater nucleosome motions. 1/2