James Stone

Psychiatrist with interest in psychopharmacology, neuroimaging, neuroscience, art, music and psychotherapy.

[James Stone @drjmstone]

Psychological treatments for depression don't seem to lead to great outcomes - just over 20% response rate in all non primary care settings... https://t.co/w54Gs6JTSQ

[James Stone @drjmstone]

@andymoz78 @pash22 @NICEComms @BlottMaggie @susan_bewley @jimgthornton @catherineroyuk @drruthannharpur I guess it's cheap, so that's a win as far as NICE are concerned

[MarkRBol @MkRBol]

Come into bed voluntarily and wait a week for a bed in a busy A&E dept or refuse to wait, get detained and they will find you a bed in prob 48 hrs

[Carmine M. Pariante @CarminePariante]

I am delighted to have my first article in the @NewHumanist: on why the war on #antidepressants is scientifically unsound and is hurting the most vulnerable in our society. You can see the subtitle - “Defending antidepressants” on the top right corner of the cover.

[Michael Okun @MichaelOkun]

Can you name all the features associated with catatonia and the current diagnostic criteria. I bet you that most of you cannot and will need to read the new review in @NEJM which rightly points out that catatonia has been 'well described but is poorly understood and that many physicians incorrectly believe that catatonia is a rare form of schizophrenia, with bizarre abnormalities of motor behavior.' Catatonia may 'linger in the shadow of delirium.'
Key points:
- Diagnosis is often missed.
- Frequently a person with catatonia may be inappropriately treated.
- DSM-5 removed catatonia as a subtype of schizophrenia.
- In emergency department presents as failure to respond to questioning (mutism) and very little spontaneous movement (stupor).
- Look for underlying causes and medical as well as psychiatric conditions.
- Anti–N-methyl-d-aspartate (NMDA) receptor encephalitis may cause acute catatonia before progressing to encephalopathy or seizures.
- Look for metabolic disorders and focal cerebral lesions.
- Medications prescribed or illicit may be the cause and could present during withdrawal.
- The less severe forms of catatonia have been described such as elective mutism (refusal to speak) or ambitendency (indecisive, hesitant movements due to conflicting goals).
- Depression, bipolar disorder, schizophrenia, or autism spectrum disorder may present with staring, mutism, immobility, or stereotypies. https://t.co/YztTTMZzy7

[Thomas Reilly @Rational_Psych]

Negative meta-analysis for sodium nitroprusside in schizophrenia (6 studies, total n 174)
@IvanKoychev @drjmstone

https://t.co/XOSMpupjgf

[Boris D Heifets @TheBorisLab]

Peer-reviewed and published today in @NatMentHealth Thank you co-authors, and particularly @SNACCNeuro for seed funding.

https://t.co/KtmcAANPke

[Gemma Brownbill @gemmabrownbill]

I tried out yet another way to stimulate nerve fibres, when Prof Vaughan Macefield visited @BSMSMedSchool (@MindBrainBody) last week. It’s not every day you get to hear your nerve firing! Managed to record sympathetic activity from my peroneal nerve through #mircorneurograpy 🪡⚡️

[Sameer Jauhar @sameerjauhar]

This is a 2009 paper. V large cohort study, 2011, showed “Use of any antipsychotic compared with no antipsychotic was associated with lower mortality (adjusted hazard ratio=0.45, 95% CI=0.31-0.67).”https://t.co/Iz2ZUqpNXw

[Amir Englund @AmirEnglund]

Randomised, double-blind, placebo-controlled trial of THC, CBD or combination finds no benefit for pain, spasticity, quality of life, or patients impression of change.
Patients expectation was a 8 out of 10 before the start of treatment.

https://t.co/iVCxEvlCwb

[David Oliver @mancunianmedic]

BBC reporting a national guide dog shortage
But the government have proposed to

Shorten guide dog training from 2 years to 6 months

Provide an apprentice route for fast track dog training

Have guide dog associates to be supervised by actual guide dogs

Introduce guide cats

[Dom Oliver @Dom__Oliver]

If you're attending #BAP2023, you're in for a treat with 3 excellent Post-Doc Symposia later today. I'll be co-chairing one: "Predicting the future today – Pragmatic approaches to precision psychiatry" with @lowrigriffiths_ @benjmnperry @smartiesoph presenting some exciting work

[The Mental Elf @Mental_Elf]

@jfcryan @UCC @carinacarbiaC @_Fabi_CZ ⭐️ Psychobiotic⭐️

@jfcryan and colleagues coined this term to refer to targeting the microbiome for mental health benefits #BAP2023

[The Mental Elf @Mental_Elf]

Next, we have @HamishMcAW who will be talking about “Applying the model of care for difficult to treat depression to bipolar disorder” #BAP2023

If you haven’t yet listened to our recent podcast episode with Hamish, you can find it here:

https://t.co/yaBO9dexA7

[Paris Lalousis @P_Lalousis]

Hello and welcome to the second day of #BAP2023

I'll be live-tweeting from the symposium: “Psychopharmacology in the Computer Age: How new Computational power can drive precision psychiatry and translational drug discovery” for @Mental_Elf #BeyondtheRoom @BAPsych

🧵THREAD

[Emmeline Lagunes 🇲🇽🇬🇧 @EmmelineLagunes]

Some examples of Psychiatry critics and antipsychiatry. It's always a delight to hear Sir Robin Murray. Key point, we are too few of us interested in the care of the mentally ill to waste time fighting each other.
@subodhdave1 #RCPsychIC @rcpsych

[John F. Cryan @jfcryan]

Acceptability, Tolerability, and Treatment Effects of Probiotics as Adjunctive Treatment in Depression

@drjmstone & colleagues in @JAMAPsych

https://t.co/1rLwSo86bi

[James Stone @drjmstone]

Our new paper on probiotics in depression - reductions in depressive and anxiety symptoms compared to placebo. Great work Viktoriya Nikolova, Lindsay J Hall, Anthony Cleare and Allan Young @KingsCollegeLon @BSMSMedSchool @SussexUni https://t.co/rOxtZQiAbG

[James Stone @drjmstone]

@LukeJelen @TheBorisLab Important to remember that ketamine induction doesn't add anything to ECT. Maybe interaction with propofol/anaesthetised state. Or maybe ketamine response is all placebo.

[James Stone @drjmstone]

@LukeJelen @TheBorisLab Appears to be strong placebo/expectancy effect. No unique effect of ketamine? Very nice work. Agree needs to be looked at in psilocybin/DMT etc.