This is an opportunity to recall that the very first clinical trial of an mRNA vaccine was the one we conducted in 2003 and published in 2008 (https://t.co/jCpKCyM75N), which was already a personalized vaccine (each patient received THEIR own custom-made mRNA vaccine) against melanoma. I’m pleased to see this approach soon to be validated and made available to patients.
The mRNA vaccine success vs melanoma in a Phase definitive 3 randomized trial today is on top of signs of success for personalized mRNA neoantigen vaccines vs pancreatic cancer, triple negative breast cancer, and non-small cell lung cancer https://t.co/cv4iXW11mw
How your daily diet affects quality of sleep.
Plant-based consumption, especially when diverse, and fiber had favorable impact. https://t.co/z48lgldzsc
As an epidemiologist, I often hear about COVID in past tense.
COVID-19 is very much still here. The last two years were the mildest COVID-19 seasons to date, but they caused a similar level of hospitalizations as two very severe flu seasons.
Enough of the cure talk. Where are the cures for these diseases?
x Alzheimer's
x Parkinson's
x Heart and vascular diseases
x Diabetes
x Hypertension
x Most cancers
x Multiple sclerosis
x Most autoimmune diseases
X Kidney diseases
x Liver diseases
x Lung diseases
x Depression
x ALS
and a long list of others
8 weeks of meditation or exercise training reduced cold and flu illness burden
Meditation reduced severity by 60% and work absences by 76%
Exercise reduced work absences by 48%
1/ We started @CuraiHQ with the mission of proving AI could outperform humans at the core cognitive work of medicine.
Today in @JAMA_Current, @ZekeEmanuel, @AbeBakerButler, @vkhosla, and I are publishing a comprehensive argument this future is here.
https://t.co/bpXMdXljsw
New—Long-term safety of oral #orforglipron in Japanese participants with type 2 #diabetes (ACHIEVE-J): a multicentre, randomised, open-label, parallel-group phase 3 trial https://t.co/sQ6hZ6Fiau
#T2D
🇦🇷 Proud to share our latest publication in @ATHjournal from the GAELp(a) Registry.
Another important contribution from Argentina and Latin America to the global understanding of Lp(a) and cardiovascular risk.
👉 1,861 patients from a nationwide multicenter Argentine registry
👉 Risk-weighted apoB reclassified 60% of participants by ≥10 percentiles
👉 As Lp(a) increased, conventional apoB progressively underestimated atherogenic burden
👉 At Lp(a) ≥300 nmol/L, RW-apoB was 1.91× measured apoB — an 86% underestimation of weighted atherogenic burden
👉 The discordance was driven primarily by Lp(a), not triglyceride-rich lipoproteins
🙌 Beyond the findings, this is another milestone for the GAELp(a) collaborative network: high-quality, multicenter real-world evidence generated in Argentina and contributing to the international lipid field. 🇦🇷
💪 Proud of this team. Proud of Argentine science.
🪢https://t.co/fsx6KeZjzG
@society_eas@magabrielama83@lschreier1@alavallecobo@JSoumoulou@nicolasrennamd@lynchsantiago@natinardelli_@sebagz1
The dangers of RFK Jr's peptide push
Example:
"If you have a few precancerous cells lurking indolently in your prostate or breast, injecting a peptide that stimulates human growth hormone might supercharge them into a tumor."
gift link
https://t.co/dKf5dcGAvf
💬 Perspective: For cognitive medical tasks, #AI alone may exceed physician-only and physician-AI hybrid care, raising policy questions about workflow, liability, regulation, reimbursement, and medical education.
https://t.co/vjt4lBUpmr
The cancer mortality hazard among pilots and flight attendants. An analysis of 503 occupations, including ground-based aviation workers and nuclear technologists, found that pilot and flight attendants had the highest and second highest proportion of radiation-related cancer deaths
@JAMAInternalMed https://t.co/kJro7QYlzp
69% of patients see their test results before their doctors, from a nationally representative sample. And a substantial proportion of these folks don't understand the results. Hello genAI
https://t.co/V7BdTUtB8E
Image-based “wireless” indices, including FFR-CT and angiography-derived FFR, are increasingly being incorporated into diagnostic and interventional cardiology. This review summarizes the current evidence regarding their clinical application and integration into routine practice. https://t.co/UdRSZfwgDB
Scientists have created the first comprehensive map of the human vagus nerve, tracing thousands of individual nerve fibers stretching from the lower brain stem to all major organs.
The map might help scientists and doctors more precisely stimulate the nerve as a potential treatment for conditions such as epilepsy, stroke, and inflammatory diseases.
Learn more: https://t.co/XRHfmivUjk @NewsfromScience
Adults who could successfully stand on one leg for 10 seconds had an 46% lower risk of dying from any cause compared with those who couldn’t complete the test.
I find this fascinating because it shows how much information can be captured by a very simple measure of physical function.
It’s another reminder that balance is probably a meaningful marker of overall health and resilience, especially as we get older.