Dr Varsha Deepu

[Papa Heme @Papa_Heme]

This image has been on every hematology board since the dawn of time.

[MEDICINE MADNESS @Doctors_GUILD]

One evening, a girlfriend notices tiny bumps appearing on her boyfriend's palms.

She asks, "What's wrong with your hands? Are these tiny blisters?

He replies, "They itch like crazy, especially after sweating or washing my hands."

She takes a closer look and notices multiple tiny, deep-seated vesicles scattered across his palms.

Now she's worried! 👀

What is the most likely diagnosis?

[Dr. Naseem Suhail @DrNaseemSuhail]

What is the diagnosis?

[Dr. Jay Thaddeus 🩺 @Jay_thadeus]

Black Hole Sign
What's the diagnosis ❓

[Dr Ihab Suliman @IhabFathiSulima]

A 42-year-old with hypertension and blood in the urine suddenly develops the worst headache of his life. His kidneys look like this. What is the diagnosis—and what deadly complication must you suspect?

[Mukul Vij, MD 🇮🇳 @vij_mukul]

#Liverpath

[Kathryn Lindsey @PathologyKate]

Greater than 10 year old minimally growing lung mass. What is it? #Boardfodder

[Dr Ihab Suliman @IhabFathiSulima]

A 45-year-old man presents with weight loss, abdominal pain, and severe hypertension. Renal angiography shows bilateral microaneurysms. What is the most likely diagnosis?

[Jerad Gardner, MD @JMGardnerMD]

35 yo F. Firm papule on cheek.
Digital slide: https://t.co/5ikeW4UVgo.
Answer ✅ https://t.co/MVEAJcwBWz
Handout & sample #pathology report template: https://t.co/oyRZpcsSvz
#pathologists #pathTwitter #dermpath #dermatology #dermatologia #dermtwitter

[Dr Ihab Suliman @IhabFathiSulima]

🚨 A 29-year-old woman presents with severe headache, blurred vision, and BP 230/130 despite three medications.

Her renal angiogram holds the clue. What’s the diagnosis?

[Arkana Laboratories @arkanalabs]

#DiagnoseThis! In the presence of a negative immunofluorescence panel, what is your diagnosis?

#renalpath #kidneypath #pathology #renal #DiagnoseThis

[Elizabeth Montgomery, MD @LizMontgomeryMD]

This pattern of esophageal injury is often associated with medications (immunotherapy frequently) or various other immunologic conditions, but this patient had a history of esophageal lichen planus. Apoptotic bodies are indicated.
https://t.co/KctUX85qSk
https://t.co/GKkBB7p0aa

[Antonio Guerrero @guerreroespejo]

30-year-old woman from Iran: 4 months of slowly progressive, multiple annular, hypopigmented, atrophic macules on her back, with raised erythematous borders; hairless, hypohidrotic and anesthetic.

Diagnosis?

#Dermatology #Medicine #IDXposts
1/2

[Dr. Khaled @kh505043]

52-year-old coal miner with rheumatoid arthritis has elevated rheumatoid factor and anti-CCP antibodies. Chest X-ray shows multiple bilateral peripheral cavitating lung nodules, while tuberculosis testing is negative.

What is the most likely diagnosis?

[Dongling Wu MD @Emmadon53528883]

Cribriform DCIS? Nah, it’s Gleason pattern 4 prostate cancer. #breastpath #GUPath

[Janira Navarro @Janiranavarro]

Ovary: Changes to WHO classification (2026)

- Ovarian tumors are separated into epithelial and non-epithelial ovarian tumors (germ cell tumors, sex-cord stromal tumors)
- Fibrosarcoma: REMOVED
- Rete adenocarcinoma: REMOVED
- Wolffian tumors moved to broad ligament chapter

Dr. Nucci. Gynecologic Pathology Masterclass #USCAP #pathology #PathX

[Ibrahim Mansoor FCAP, FIAC, FACHDM @drpathai]

45-year-old woman. Anal fistula.

Glands in the tract, where no glands should be. Rounded and lobulated, with a pushing edge.

A) Entrapped anal gland or duct remnant
B) Well-differentiated adenocarcinoma
C) Can't call it without stains

Reply with your call and one reason. The answer lands at noon.

#PathTwitter #GIPath

[Ibrahim Mansoor FCAP, FIAC, FACHDM @drpathai]

Clean surface. Still cancer.

Answer: C. HPV-independent cervical carcinoma.

The trap: we expect surface dysplasia above a cervical glandular cancer. When the surface is clean, we hesitate.

What settled it:
1. Glands truly invasive, stroma reactive
2. Cytology deceptive, but malignant
3. p16 NOT block-positive

They often lack surface dysplasia, mimic benign glands, and tend to behave more aggressively.

And screening that relies only on primary HPV testing will miss them.

#Pathology #GynPath

[Ibrahim Mansoor FCAP, FIAC, FACHDM @drpathai]

Friable cervical lesion. Bleeds on contact.

Deep glands. Clean surface. No dysplasia and no AIS on top.

A) Benign hyperplasia or tunnel clusters
B) HPV-associated adenocarcinoma
C) HPV-independent carcinoma

Reply with your call and one reason. Answer tomorrow at noon.

#Pathology #GynPath

[aung phyo @pathphyo]

Omental cake biopsy in a case of metastatic adenocarcinoma of colonic primary. Note luminal dirty necrosis within the malignant glands.
#pathology #GIPath #CRC