David Szuts

Scientist studying mutagenesis and cancer at the Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest

[David Szuts @DSzuts]

Are pesticides mutagenic? We assayed the mutagenicity of all six IARC 'probably carcinogenic' pesticides in cell culture and found that two were mutagenic with specific spectra, but #glyphosate was not. See in @chemosphere https://t.co/BGpgPs0jZx

[David Szuts @DSzuts]

DNA repair and mutagenesis are intricately linked - our comprehensive review on mutagenesis due to defects in each repair pathway is now out @repair_dna
https://t.co/9Wg47HsgIH

[David Szuts @DSzuts]

Opulent environment at the excellent #MITS24 mutation meeting in Edinburgh, where Eszter Németh won a poster prize!

[David Szuts @DSzuts]

It was an honour to attend the inaugural lecture of Katalin Karikó at the Hungarian Academy of Sciences. An inspirational story from a very humble person.

[David Szuts @DSzuts]

Great news that our institute's DNA repair community is expanding! Also, to keep with the times, we have changed the name of the institute from Enzymology to Molecular Life Sciences.

[Gergely Rona @rona_gergely]

I'm excited to share that I'm joining the Institute of Molecular Life Sciences at the HUN-REN RCNS in Budapest as a Group Leader. My lab will investigate DNA repair mechanisms in terminally differentiated cells. https://t.co/PAkafDYRX3

[David Szuts @DSzuts]

@paganolab @NIH Papers improve after peer review. My papers certainly do. And I have reviewed many manuscripts with fundamental methodological problems that need more than a skim read to spot.

[David Szuts @DSzuts]

@LauraGreaves81 Oh... will grow to be a good runner!

[David Szuts @DSzuts]

@ProfessorAntony Congrats! I'm still waiting...

[David Szuts @DSzuts]

New year, new species! Pleased to report the mutagenic effect of regeneration in collab with Jelena Vermezovic @IFOMresearch @NAR_Open: Mutational profile of the regenerative process and de novo genome assembly of the planarian Schmidtea polychroa https://t.co/Z6BxxQ0iD2

[David Szuts @DSzuts]

Nice to take a few days off in the wilderness before getting back to business!

[David Szuts @DSzuts]

Planaria, here we come! (with a paper soon)

[David Szuts @DSzuts]

@SerenaNikZainal @AndrewHouk2 @HarmitMalik @NatureGenet @GeneChChKoh @CR_UK @NIHRresearch @BasserBRCA Indeed, this is a very high rate of mutagenesis. Higher than what I have seen with out-and-out mutagens like MMS (or with any chemotherapeutic agent)

[David Szuts @DSzuts]

@OchsFena @UCPH_BRIC Congrats for the fearsome microscope!

[David Szuts @DSzuts]

A short but very inspiring visit to Claus Sørensen's lab, presenting our latest results on DNA damage bypass at @UCPH_BRIC Uni of Copenhagen

[David Szuts @DSzuts]

@davidmasp That's because the image was not really a link, I added the title. The link is above. But many thanks!

[David Szuts @DSzuts]

Mismatch repair is very important to avoid mutagenesis, but how do mismatches arise? In a fresh NAR paper we show that oxygen triggers mismatches through a replicative process rather than direct DNA damage. https://t.co/mAd7PVr76x

[David Szuts @DSzuts]

Listen to this, it is all so human.

[The Nobel Prize @NobelPrize]

“Ten years ago I was kicked out and forced to retire.”

Our new medicine laureate Katalin Karikó (@kkariko) told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges.

Ten years ago, Karikó was still doing all her experiments by hand but today she has been awarded the medicine prize for her research on mRNA, which led to the development of COVID-19 vaccines.

Listen now:

[David Szuts @DSzuts]

Untypical lab meeting and progress report in the Szuts group

[David Szuts @DSzuts]

Although translesion synthesis promotes base substitutions, it also protects the genome from deletions and chromosome instability

[David Szuts @DSzuts]

What are the main causes of spontaneous mutagenesis? Proud to present our new paper reporting that translesion synthesis (REV1) or oxidative processes (via PRIMPOL) are responsible for mutations in cultured human cells https://t.co/l3wwDlUvMS

[David Szuts @DSzuts]

PRIMPOL promotes base substitutions that resemble oxidative mutagenesis