Edridge D'Souza

Believer that fruit fly researchers should be called drosophilosophers |

@UMassBMB | @GeneticsCam via @ChurchillCol | @ColumbiaPS MSTP student

[Edridge D'Souza @edridgekd]

"The NIH is the world’s greatest funder of biomedical research, and second place isn’t close."
Glad to have been part of this delegation on Capitol Hill advocating for federal funding of scientific research.
https://t.co/3ccAkdX6WL

[Edridge D'Souza @edridgekd]

Excited to announce my new NIH F30 grant in the @BizarMd lab! Congressional funding for NIH research is what has made the United States the undisputed leader in biomedical breakthroughs, and every dollar we invest generates $2.50 more for the economy

[bizarMD @BizarMd]

Excited to share a new paper: https://t.co/087iX9SkJd @CellCellPress: a framework to accelerate variant classification, diagnosis & treatment of immune disorders & genetic disorders more broadly. Led by superstar, juggernaut & future dermatologist @zwalsh96

[Zach Walsh @zwalsh96]

Thrilled to share the latest work from my PhD in the @BizarMd group! This has been a dream MD/PhD project, culminating in data that has already enabled access to precision therapy for a patient. Tweetorial below:

[LomvardasLab @LomvardasLab]

Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment: Cell https://t.co/JSGSZw5a8J Thrilled to see this transformative paper published- and so sad that its NIH funds are frozen!

[somnath tagore @SomnathTagore]

Happy to share our manuscript “Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases” published in @NatureMedicine. Congrats @lcaprio412. Thank you @BizarMd. https://t.co/HIto1PoCJB

[Nature Medicine @NatureMedicine]

Multi-omic single-cell and spatial analyses of lung cancer brain metastases from multiple cohorts identify high levels of chromosomal instability and a neural-like profile in metastases compared to primary tumors

https://t.co/BQpUT4tCmL

[Nature Biotechnology @NatureBiotech]

Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens https://t.co/4UVmPI1uXP

[Edridge D'Souza @edridgekd]

@triciahoho @BizarMd Congrats Tricia!

[Edridge D'Souza @edridgekd]

@dr_alphalyrae I recently learned about the Goodsell collection on PDB which is free for use under CC-BY. Watercolor interpretions of cellular processes that you can freely make your own prints of

https://t.co/Cl2gqSp3ev

[Edridge D'Souza @edridgekd]

@lpachter To favor a "harm reduction" approach to UMAPs, should we ask that any published figure also include supplemental figs run under different values of the seed/reduction parameters?

ofc doesnt remove some of the fundamental criticisms but at least mitigates data artefacts like this

[Graham Coop @Graham_Coop]

The use of the phrase “ancestry-specific variant” is increasing, particularly to describe rare Single-nucleotide variants (SNVs). But these alleles are not ancestry-specific. They have not yet been found elsewhere, but they will be. 1/n

[Edridge D'Souza @edridgekd]

This but unironically

[Hank Green @hankgreen]

NYTimes connections is always like, “Oh, you don’t live in New York? That sounds like a you problem.”

[bizarMD @BizarMd]

Very excited to share new work from the lab dissecting mechanisms of liver-metastatic organotropism in melanoma and other cancers. Huge congrats to fearless post-doc @meri_rogava (on the job market!) who led this multi-year study! Below a brief summary...
https://t.co/t90IreLZzo

[bizarMD @BizarMd]

Interested in T cell biology? Cellular immunotherapies? Base editing? And an amazing example for scientific reproducibility- this @biorxivpreprint & tweetorial are for you! TL:DR- we made primary human T cells better cancer killers! https://t.co/WjFf4EKO9a

[Edridge D'Souza @edridgekd]

@hankgreen Green's Razor strikes again

[Edridge D'Souza @edridgekd]

somewhere out there, a structural biophysicist working with Z DNA feels represented

[Michael 英泉 Eisen @mbeisen]

I guess it should come as no surprise that AI image generators trained on the Internet would produce a lot of left-handed DNA, but it is disappointing

[Edridge D'Souza @edridgekd]

When asked for comment on why it took so long, all the scientific community could say was "sry that's par for the course"

[nature @Nature]

Nature research paper: The complete sequence of a human Y chromosome https://t.co/d1Zu9Xw9DK

[mauv @ThatsMauvelous]

satoshi? oh you mean the time-traveling ai that hit us with an economic infohazard in order to accelerate gpu production?

[Edridge D'Souza @edridgekd]

My apostrophe is a useful screening tool to guesstimate which websites are more/less secure on the backend. If you can't properly handle this character, I don't trust you to deal with a Bobby Tables injection!

[Monica de la Cruz @mdelacruzin]

shit is so annoying