Ellie

ID physician in 🇰🇷 Interested in ASP and vaccines.

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🔥Just published 🔥
IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP Multisociety Position Paper: Hospital Strategies to Improve Sepsis Outcomes #idxposts https://t.co/afZ7q9qVKB

[Barack Obama @BarackObama]

A while back, I revisited a few of the books that made an impact on me as a young man, influencing how I think about family, faith, race, politics and America: The Fire Next Time by James Baldwin, Song of Solomon by Toni Morrison, All the Pretty Horses by Cormac McCarthy, Gilead by Marilynne Robinson, All the King’s Men by Robert Penn Warren, and Tinker, Tailor, Soldier, Spy by John le Carré.

[Brad Spellberg @BradSpellberg]

Okay you Med Twitter cefadroxil-ites! The long awaited cohort study of cefadroxil for bacteremia (Including staph aureus!) with or without osteo is here! Have at it!
https://t.co/cmS0uY9fQg

[Oliverio @LuisOliverio]

Las "nuevas definiciones de insuficiencia cardíaca (IC)" de la AHA (2026). Ya tienen días, pero la verdad no las había podido leer. Algunas notas:

🔴 La (IC) es un síndrome caracterizado por hallazgos sugestivos de congestión pulmonar o sistémica, o cambios en el gasto cardiaco por a una anomalía cardiaca estructural o funcional.
🔴 Ahora no se usa un corte específico de la FEVI (fracción de eyección del ventrículo izquierdo - antes +-50%), y quedan solo:
• IC con fracción de eyección reducida;
• IC con fracción de eyección preservada; e
• IC con fracción de eyección mejorada (reducida que mejoró)
🔴 La IC progresa por etapas:
• A: en riesgo personas en riesgo
• B: cardiopatía estructural (ahora "prefalla cardíaca")
• C: IC sintomática
• D: enfermedad avanzada
🔴 Hay métodos nuevos con ECG por IA que clasifica y predice con precisión la disfunción sistólica ventricular izquierda y la cardiopatía estructural

El tema ya está actualizado en Accio (https://t.co/FQyQuLPKMe) y el artículo completo está en el canal (https://t.co/huxhaokRBO).

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

The post-surgical duration of antibiotic treatment for patients with active IE receiving heart valve surgery is uncertain
🆕💥🔴Retrospective observational cohort study
No relapsed EFIE occurred and there was no difference in survival when comparing the groups that received shorter versus longer post-surgical antibiotic durations #idxposts https://t.co/3ZRK7V2SR0

[Oliverio @LuisOliverio]

Aún no sale "oficialmente", pero aquí están las últimas guías 2026, de la IDSA, de Bacteriemia por Staphylococcus aureus. Puntos clave:

🔴 Nueva clasificación: Abandona los términos "complicada/no complicada". Ahora es “Bajo Riesgo” o “Riesgo alto” (bacteriemia comunitaria, hemocultivos positivos ≥ 48h, o dispositivos).

🔴 Recuerda siempre tomar al menos 2 sets a las 48 horas del primer cultivo positivo. Repite cada 24-48 horas hasta negativizar. El primer cultivo negativo es el "Día 0" para contar los días de antibiótico.

🔴 Ahora se recomienda Ecocardiograma a todos. Solicítalo transesofágico si hay factores de riesgo de endocarditis.

🔴 Si un paciente es de riesgo incrementado y no le encuentras el foco tras la evaluación inicial: 18F-FDG-PET/CT.

🔴 Tratamiento por 14 días desde el "Día 0" en bajo riesgo. En alto riesgo también, si no hay metástasis. Tratamientos más largos se reservan para fallas de control del foco o bacteriemias prolongadas.

La pueden bajar directo en el canal (https://t.co/3O93s10lns).

[Isaac Bogoch @BogochIsaac]

A Danish cohort study of adults aged 65 and older demonstrated that COVID-19 vaccines continued to reduce the risk of hospitalization and death. The data are from this past winter.

https://t.co/nHNfu7LHkz by Hansen et al.

[NEJM @NEJM]

In the SNAP trial, cefazolin was noninferior to flucloxacillin or cloxacillin with respect to 90-day mortality in patients with methicillin-susceptible Staphylococcus aureus bacteremia and had fewer nephrotoxic effects. Read the full trial results and Research Summary: https://t.co/5Z39siPUhS

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕🔥🟢Post hoc subgroup analysis of the BALANCE RCT 7 Vs 14d duration of antibiotic therapy for bacteremia in immune compromised hosts
1037 immune compromised patients
No statistically significant mortality difference between groups with the upper bound of the confidence intervals being below the initial BALANCE trial’s 4% non-inferiority margin
https://t.co/Oi7m4QOIUl

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Pseudomonas sparing’ antibiotics, is it time to rethink this notion?
🆕💥🟢Study
Prolonged in vitro exposure of P. aeruginosa to subinhibitory concentrations of antibiotics lacking intrinsic antipseudomonal activity (Ceftriaxone,moxi,Erta) selects for stable,heritable resistance to antipseudomonal agents #idxposts https://t.co/xcJcYfa9ci

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Amazing 😍
🔥SHORTEN 2 RCT
A 7-day treatment course is superior to 14 days for uncomplicated Pseudomonas aeruginosa bacteremia bacteremia, achieving similar clinical response rates with lower antibiotic exposure, fewer superinfections, and fewer serious adverse events

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🔥Our article in EJHP is now published🔥🌟s @drgabx @BradSpellberg

“Universal high-dose meropenem for antimicrobial-resistant Gram-negative infections: evidence or overreach?”

We argue that the IDSA AMR guidance recommendation for universal high-dose meropenem (2 g IV q8h as 3h EI) for all infections other than uncomplicated cystitis is largely based on PK/PD extrapolation & expert opinion without supporting clinical outcomes data.
https://t.co/zhFI8w6Bws

[ESCMID @ESCMID]

This online course will provide up-to-date information on the clinical relevance of microbial consortia & quorum sensing in inter-microbial cooperation, as well as IPC strategies for and management of biofilm-associated infections. Sign up today!

https://t.co/miAdBy0fHS

@eucic1

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕💥🟢FOVOCIP RCT
Fosfomycin Vs ciprofloxacin for febrile neutropenia prophylaxis in high-risk haematological adult patients
Fosfomycin* did not demonstrate non-inferiority to ciprofloxacin in the prevention of febrile neutropenia in high-risk haematological patients
Gram negative bacteria were responsible for 90% and 10% of the bacteraemias in the fosfomycin and ciprofloxacin group, respectively.
The higher incidence of Gram-negative bacteraemia also discourages its use
Thanks @Inox94 https://t.co/LWmVCEL1rs

[Clinical Infectious Diseases @CIDJournal]

Virological Failure on Long-Acting Injectable Cabotegravir and Rilpivirine: An Analysis of Subtypes, Drug Levels, Resistance, and Therapeutic Implications

✅ Just Accepted
🔗 https://t.co/H5jMvCT1D3

[Sigal Yawetz MD @sigal_md]

@IdVilchez @BradSpellberg @JulianVentres @ABsteward @DrToddLee Bryson AL, Bhalodi A, Liesman RM, Mathers AJ. Cefazolin as a predictor of urinary cephalosporin activity in indicated Enterobacterales. J Clin Microbiol. 2024 Apr 10;62(4):e0078821. doi: 10.1128/jcm.00788-21. Epub 2024 Mar 8. PMID: 38457194; PMCID: PMC11005412.

[NEJM @NEJM]

Tuberculosis remains a leading cause of death worldwide among persons with HIV. In this report, the effect of the PEPFAR program on incident cases of tuberculosis and related deaths is presented. Read the full report: https://t.co/qmpnYA45W7

@CDCgov | #WorldTBDay

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🔥Just published🔥
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026 : Critical Care Medicine #IDXposts https://t.co/jRP9hZFI8W

[YO_ID @YO_ID_0722]

How to safely discontinue antifungal treatment in invasive pulmonary aspergillosis? – Clinical considerations in haematology

@CMIJournal

https://t.co/y9vpDFaPQU

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🔥Just published 🔥
TAPER-V RCT
Initial Vancomycin Taper for the Prevention of Recurrent Clostridioides difficile Infection
In this randomized clinical trial of 256, a 4-week vancomycin pulse and taper regimen *had a probability of 74% to be superior to astandard 2-week pulse regimen in patients a first episode or first recurrence of CDI
*All patients received 14d pulse of vanco (standardized at 125 mg orally 4 times a day at the time of recruitment) →taper (125 mg q12h ×7d,then 125mg q24h ×7d) vs placebo for management of CDI (first episode or recurrence).
Vanco for 10d is obsolete! #IDXposts
https://t.co/8ChVE5sLb2