Dr Emmanuelle Vire

Epigenetics in human diseases. Empowering others and enabling cool science.
@UCL
@ULBruxelles @GurdonInstitute @Cambridge_uni @eLife

[Dr Emmanuelle Vire @EmmanuelleVire]

This is a unique opportunity to work in a stimulating environment with one of the best mentor in the field @smead2 on a project that's super exciting. You'll make a contribution to the field of rare neurodegenerative diseases, and work with talented people. APPLY!

[Simon Mead @smead2]

MRC Prion Unit at UCL, Fitzrovia, London. We are looking to recruit a temp Research Support worker to work on sulfatides in prion diseases. A short term post for staff between jobs, pre-PhD / post doc. Will involve DNA/RNA work, tissue culture, WB. DM me https://t.co/S0ka7eJ7pc

[Simon Mead @smead2]

MRC Prion Unit at UCL, Fitzrovia, London. We are looking to recruit a temp Research Support worker to work on sulfatides in prion diseases. A short term post for staff between jobs, pre-PhD / post doc. Will involve DNA/RNA work, tissue culture, WB. DM me https://t.co/S0ka7eJ7pc

[Dr Emmanuelle Vire @EmmanuelleVire]

@RhiannonLaban Amazing, so proud of you!

[Dr Emmanuelle Vire @EmmanuelleVire]

@MRC_Prion Privileged to work with these talented colleagues. Incredibly grateful for the continuous support and kindness from everyone at the @MRC_Prion

[MRC Prion Unit at UCL Institute of Prion Diseases @MRC_Prion]

Today we celebrate Women in Science. Here’s a nod to women @MRC_Prion who are changing the world through their acts of courage & determination to tackle the most challenging problems in the field of Prion diseases & dementia.
#WomenInScience #UCLwomenInScience

[Dr Emmanuelle Vire @EmmanuelleVire]

Should add that emergency phone number of @SandfordsLondon is not recognised

[Dr Emmanuelle Vire @EmmanuelleVire]

62 days since I first contacted @SandfordsLondon about the heating problem.
Many emails and reporting forms filled. Absolutely nothing has been done. It's currently 7C in the main room.
What now?
#coldweather #propertymanagement

[Dr Emmanuelle Vire @EmmanuelleVire]

62 days since I first contacted @SandfordsLondon about the heating problem.
Many emails and reporting forms filled. Absolutely nothing has been done. It's currently 7C in the main room.
What now?
#coldweather #propertymanagement

[Dr Emmanuelle Vire @EmmanuelleVire]

@Rachel_GA_ @WomeninNeuro_UK Thank you!

[Dr Emmanuelle Vire @EmmanuelleVire]

Made me reflect on my career and life over the past 20 years or so.
From @FuksLab then @TKLABUK @GurdonInstitute and work with @SPJacksonGroup @CaldasLab @eLifeCommunity
To #cjd #prions @UCLBrainScience @CJDFoundation

[Dr Emmanuelle Vire @EmmanuelleVire]

Honoured to talk at this event tonight.

Incredibly grateful for the trust and support from everyone I work and worked with @ARUKscientist @MRC_Prion @smead2 @francois_kroll @ThanosDim3 @scienceandbears @BiochEmJones @tjm_sci @saobettencourt @RhiannonLaban and many others

[WiNUK: Women in Neuroscience UK 🧠 @WomeninNeuroUK]

Get ready for the launch of Women in Neuroscience (WiN UK)! 🧠💗

We are thrilled to have our incredible speaker @EmmanuelleVire, Associate Professor at University College London, speak about her career journey as a female academic 👩‍🔬

#WiNUK #Womeninneuroscience

[Dr Emmanuelle Vire @EmmanuelleVire]

@danetteldaniels @AdelmanLab @David_Lab_MSK Was fantastic to see you all again. What a dream line up! Thanks @FuksLab for organising #EEHD22

[Dr Emmanuelle Vire @EmmanuelleVire]

@MarcusBuschbeck @FuksLab And congrats for the prize @MarcusBuschbeck

[Dr Emmanuelle Vire @EmmanuelleVire]

@MRC_Prion @ThanosDim3 @smead2 Super proud of @ThanosDim3

Many thanks to examiners @FrattaLab and Twitterless Ruslan Sadreyev.

[Dr Emmanuelle Vire @EmmanuelleVire]

@GoCasteloBranco Massive congratulations!

[Dr Emmanuelle Vire @EmmanuelleVire]

@GoCasteloBranco @ThanosDim3 Thanks Goncalo. It was super helpful to chat about these data with you many moons ago!

[Dr Emmanuelle Vire @EmmanuelleVire]

Now online: our single nuclei transcriptomics study of prion disease. Longitudinally in mice. At end stage in human.

A tour de force from @ThanosDim3
And Twitterless Fuquan Zhang.
https://t.co/9bJTTER1mb

[Dr Emmanuelle Vire @EmmanuelleVire]

@scienceandbears Thanks Luke!

[Dr Emmanuelle Vire @EmmanuelleVire]

@cureffi @ThanosDim3 Dauting indeed.
Yes we did. All credit to @ThanosDim3
The struggle was real. Also lots of support and discussions with internal safety committee.

That was one of the reasons for using splitseq, it was potentially compatible with bsl3 environment. Happy to share specifics

[Dr Emmanuelle Vire @EmmanuelleVire]

@tjm_sci helped visualizing these findings using spatial technology.

And finally we performed RNAseq in frontal cortex from sCJD patients and healthy controls and found overlapping signatures between mice and human diseases.

[Dr Emmanuelle Vire @EmmanuelleVire]

29 resurgent genes show an oscillating pattern of dysregulation whereby affected at 20dpi and then again at 120dpi and onwards.

Early genes are only affected at 20dpi.

Late genes showed dysregulation at 120dpi and onwards.