misha

Doing cancer research, but I am interested in everything.

[Nature Medicine @NatureMedicine]

In an interim analysis of a phase 1/2 trial in patients with glioblastoma, a genetically-engineered autologous stem cell transplant was well tolerated, with stable engraftment and evidence for immune reprogramming.

#cancerresearch

https://t.co/HkIYr8HIpH

[misha @ermakov_mikhail]

@theojaffee I never understood why they even think it’s a useful feature 🥲

[Prof. Nikolai Slavov @slavov_n]

95% of papers reporting antibody-based analysis of p16-INK4a used antibodies for an unrelated protein, p16-ARC.

Despite using the wrong antibody, authors reported the expected results:
> Genetic perturbations of p16-INK4a altered reported p16-ARC levels.

1/

[misha @ermakov_mikhail]

@slavov_n I feel some companies already saw this issue coming 🙈

[misha @ermakov_mikhail]

I still remember reading about it in Siddhartha Mukherjee’s book when I was in med school. In a year, it will be 10 years into my cancer research career (started in med school + I just finished my PhD)

[Toni Choueiri, MD @DrChoueiri]

In 1948, Sidney Farber and colleagues published his work in @NEJM that helped open the door to modern chemotherapy.

Seeing that history from the same institution — especially after a remarkable #ASCO26 with major plenary contributions and @NEJM papers from @DanaFarber — is humbling.

A powerful reminder that progress in oncology is built across generations: by patients, scientists, clinicians, and teams who keep asking what might be possible.

[misha @ermakov_mikhail]

Best explanation so far

[Benjamin Todd @ben_j_todd]

Plastic surgery is most noticeable when it's bad, so it's more widespread and successful than it looks.

Same with AI writing.

[misha @ermakov_mikhail]

Louder please 🙆🏻‍♂️ We need these realistic voices in the anti-aging community.

[Arthur MacWaters @ArthurMacwaters]

@maxmarchione eternal life is a bad goal
100 years of super healthy life is a great goal

[misha @ermakov_mikhail]

@jmkettle I am glad you are back here. We need this energy ⚡️

[misha @ermakov_mikhail]

PhDmaxxing: completed

[misha @ermakov_mikhail]

@ChiragNepal @arjunrajlab TCGA papers 👀

[misha @ermakov_mikhail]

I feel the problem would be picking which chromosome to eliminate (or add in case of deletions?) 🙃 (picture from the ichorCNA paper, but often there are even more alterations)

[Jason Sheltzer @JSheltzer]

@exosome yes - aneuploidy is an under-appreciated driver of cancer, aging, and other significant conditions. we showed that in cancer, if you eliminate specific aneuploid chromosomes, you block malignant growth.

[misha @ermakov_mikhail]

@AndieWinnipeg Congratulations!

[misha @ermakov_mikhail]

PhD presentation maxxing, I guess

[Jake Wintermute 🧬/acc @SynBio1]

At this point it would be more efficient to keep a registry of the Western blots that aren't fake

[Erin Price-Wright @espricewright]

If you're a naturally anxious person, I recommend pursuing a high stress career path where at least you'll be compensated for anxiety you're going to have anyways.

[misha @ermakov_mikhail]

I have a PhD defense in two weeks, but ngl I cannot believe it’s happening 🥹

[misha @ermakov_mikhail]

@super_jrub Your coffee machine is right on your desk 😭 I would drink like 14 cups a day if it was so close haha

[aru @arubikscube]

"virtual cells" do we even have virtual FBS

[misha @ermakov_mikhail]

The paper got revised today. Reviewer 3:

[Aaron Ring @aaronmring]

When reviewing waterfall plots at AACR (and elsewhere), never forget the meaning of each line and what it means for patients and their loved ones.