Together with UC Berkeley we are announcing the laser phase plate - a breakthrough in atomic resolution imaging. This is the brightest continuous wave laser in the world, 100 million times the intensity of the surface of the sun.
Phase contrast plays an important role in microscopy, but it was thought close to impossible for electron microscopy, where it would require interfering with an electron beam. Holger Mueller and Robert Glaeser proposed exactly this using a standing wave laser. It has taken over 15 years to make this a reality. Biohub partnered with UC Berkeley and Mueller to support this work and to engineer and build the technology.
Contrast has been the critical barrier to achieving atomic resolution imaging of the cell. In cryo-electron tomography, a cellular imaging technology that uses electron microscopy, the low contrast makes it impossible to resolve anything but the largest proteins within their cellular context. The laser phase plate removes that barrier.
With advances in AI this breakthrough in contrast will start to open up a new frontier in structural biology, that will allow us to see the molecular machines of the cell, and how they assemble into far more complex and dynamic systems, and understand how they work.
The interface of the future is human.
We’ve raised a $40M Series B from CRV, Scale, Sequoia, and YC to teach machines the art of being human, so that using a computer feels like talking to a friend or a coworker.
And today, I’m excited for y’all to meet the PALs: a new human-computing interface.
PALs are emotionally intelligent, multimodal, and capable of understanding and perceiving. They can see, hear, reason, and even look like us.
We’re releasing our 5 favorite PALs to start. Each PAL has its own distinct personality- from AI assistants to best friends.
PALs:
- Meet us where we are. Face-to-face over video call, on the phone, or even by text.
- Are always thinking. They’re proactive, reach out first, remind you about what you forgot, or might just check in on you.
- Understand us, finally. PALs can see us, understand our tone, emotion, and intent, and communicate in ways that feel more human.
- Evolve with you. PALs have advanced memory, remember your preferences and needs, and adapt themselves over time.
- Are capable. PALs can handle complex tasks — from responding to your emails to moving your schedule around to creating docs and doing research for you.
Science fiction promised us a new human-computer interface, beyond the GUIs of yesterday, a human-like interface that would feel second-nature to use. That future never came, until now.
Charlie’s story brings this idea to life.
We’re excited for you to meet Charlie and his PALs for free at https://t.co/Kv2ep94noE
Enjoy the film 👇
What if Studio Ghibli directed Lord of the Rings?
I spent $250 in Kling credits and 9 hours re-editing the Fellowship trailer to bring that vision to life—and I’ll show you exactly how I did it 👇🏼