Group Leader at @UnimedizinMainz | @ginsosagelab Res. Associate. Chromatin, rare diseases and organelle networks. Opinions expressed here are solely my own
Our most recent work on the “function and evolution” of #nuclear_speckles is now online at Cell @CellCellPress
https://t.co/8QvEbVcofu
Read the thread 👇for the highlights of our findings.
Transposable Elements LTR7 as mechano-responsive enhancer elements
Matrix stiffness (40 vs 1 kPa)▶️
YAP/TEAD1-BRD4-CTCF▶️
LTR7 (FAM-LTR7)▶️
FAM189A2▶️
⏬definitive endoderm differentiation hESC
352 TE subfamilies changed by Stiffness🤠
Among "238 LTR7 loci coregulated by both matrix stiffness & YAP, 59 regulated by stiffness alone and 8 by YAP alone"
@YaruiDiao@NatureCellBio 2025
https://t.co/4hvmBlOabv
Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️https://t.co/kz0macEMTX - Please share the Open Call among potential candidates.
Just out! Aneuploidy alters cellular proteome and affects many functions. One protein, p62/ SQSTM1, becomes highly abundant and creates cytosolic bodies in cells with extra chromosomes.
https://t.co/4TGS1MltUy
We are so happy to be on the cover @sarahhoelzl@amycaoart 🎉 The cover depicts the Three Fates, who manipulate the threads of life and death. The Fates are shown as three older women, unraveling the threads of the inactive X chromosome during aging. https://t.co/dP4Er7B4d6
Very excited to share our latest work in @MolecularCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. https://t.co/3JLKZ04eYx
Can metabolism regulate more than bioenergetics during human development? Our new study says YES! We show that metabolism influences cell fate choice in human naïve pluripotent stem cells, histone acetylation, and trophectoderm maturation. https://t.co/5Ms6tNyT5l @NatureCellBio
Excited to be part of Freddie& Co's fascinating work! Who knew "Sea-Monkeys," a child's first pet for many, would reveal such cool insights about sex chromosome regulation and aging differences? A treat for fans of evo-devo and non-model organisms! #ScienceCollaboration#Genomics
🚨Happy to share our newest work from fabulous PhD student Frederic - he was brave enough to add a new species to our #zoo 🦀 enjoy what Crustacean #sexchromosomes and #H4K16ac teach us about #epigenome evolution and #ageing https://t.co/sGF0LiIeny
✨New issue! ✨
Check out the latest in #metabolism research from across all disciplines.
Read about #Macrophages, #Tcells, #Circadian biology, the effects of #Diet on #Body and #Brain - and many more topics!
https://t.co/JKcHxpyhZv
I am super proud to share the first Andergassen Lab preprint! Here, we introduce a new framework to decode the non-coding genome, led by the outstanding work of @HasenbeinT and co-authors @sarahhoelzl, Stefan Engelhardt @TU_Muenchen@dfg_public@trr267 👇🧵
🚀 Excited to share my journey in transformative tissue clearing for biomedical imaging! Our research at @HelmholtzMunich is making the invisible visible, unlocking new possibilities for medicine and AI-driven discoveries.
With pleasure we share our preprint reporting robust and cost-effective expansion of naive human Pluripotent Stem Cells without feeder cells. A fantastic collaborative effort with @leeboratory@JZylicz @vincentpasque @Nrivron
https://t.co/cHWDqE0d7i
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Excited to share our latest study, published in @NatureComms, on X-linked lncRNA loci and their epigenetic signatures! Here we dissected the in vivo roles of Crossfirre, Firre, and Dxz4, exploring their potential impacts on imprinted & random XCI, as well as on autosomes 👇