The serum free light chain FLC assay. Tutorial. #MedTwitter#MyelomaVR
Frequently ordered and frequently abnormal. This thread will reduce unnecessary headaches and referrals.
1/ Don’t order it unless you are suspecting myeloma, amyloid or related disorder
Diagnosis of enteropathy-associated T-cell lymphoma (EATL) on peripheral blood: A pleiomorphic morphology and an unusual immunophenotype https://t.co/2vTta4TIDj #lymsm
My first cover story in this month's issue of @Cancer_Cell! 🍾
"On the cover: Friedrich et al. (711–725) reveal the mode of action of bispecific antibodies in patients with multiple myeloma."
Check it out:
https://t.co/kA5G16XLYN
https://t.co/MNgCa8SaVA
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FOCUS ON MCHC, NOT MCH
When choosing between mean corpuscular Hb (MCH; weight of RBC in Hb) and mean MCHC (the concentration of Hb inside the cell; think central pallor), it is the latter that provides discriminatory power in the ddx of anemia.
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Why us the term iron deficiency anemia (IDA) to describe a patient whose main complaint is pica or restless legs? Why not refer to IDA as iron deficiency WITH anemia (to separate it from non-anemic ID and acknowledge other manifestations of ID)?
Just thinking out loud 😀
Here is my method to conduct (and automate) a literature review.
Using Google Scholar, @scite , @litmaps , #ChatGPT, @zotero and @obsdmd.
Tutorial with examples and best practices:
👇
📄Based on #karyotype and #mutation status of 9 genes -25 genes in a subset of cases- #MDS can be separated into 9 biologically distinct subgroups. The groups better reflect biology than blast counts & might also help to refine therapeutic strategies.
https://t.co/je5QucFEHK
Que grande @LabOrfao ! Habría que explicarles a nuestros políticos lo que este investigador es capaz de contribuir a la internacionalización de España en diagnóstico, clínica, educación e generación de empleo productivo y propiedad intelectual por cada Euro que le financiamos !
In 2022 we had two more new treatments approved for myeloma: cilta-cel (CAR-T therapy) and teclistamab (BCMA bispecific).
We are making steady progress. #MedTwitter