fhrątzLAB

fhrątzLAB is led by @drFhratz😎 and is located at @czt_uam. Focused on mechanochemistry🫨 and green chemistry ☘️.

[fhrątzLAB @fhratzlab]

😏🫨 We turned a classic Corey-Fuchs reaction into a mechanochemical variant!

[Dawid Frąckowiak (dr Fhrątz) @drFhratz]

🤩 A huge success for Basia @dokkaebigirl!

🧐 Basia’s paper, “Reinventing the Corey–Fuchs Reaction under Ball Milling Conditions: A Mechanochemical Pathway to Bromoalkynes”, has just been published in ACS Omega @ACSPublications!
📲 LINK: https://t.co/7NIFzBqAIv

🧪 We have brought the classic Corey–Fuchs reaction—a well-known two-step name reaction used to convert aldehydes into alkyne derivatives—into the world of mechanochemistry! The developed protocol is carried out entirely without solvents and consists of two independent ball-milling steps:
1️⃣ the synthesis of 1,1-dibromoalkenes using only half the conventional amount of triphenylphosphine,
2️⃣ dehydrohalogenation, which—contrary to expectations—leads to 1-bromoalkynes rather than terminal alkynes.

😌 We were unable to develop a one-pot protocol, as the nature of the reaction and the by-products formed during the process essentially rule out such an approach. Another challenge was presented by aldehydes containing acidic protons (e.g. phenolic –OH or carboxylic acid –COOH groups), which caused the decomposition of the in situ generated dibromomethylenetriphenylphosphorane (Ph₃P=CBr₂).

🙂‍↕️ On the other hand, we significantly reduced the reaction time and achieved a clear improvement in green chemistry metrics, including the Process Mass Intensity (PMI) and E-factor. Our results demonstrate that both the electronic properties of the substrates and the milling parameters play key roles in determining the efficiency and selectivity of the process, further expanding the potential of mechanochemistry as a more sustainable approach to organic synthesis.
#mechanochemistry #namereactions #coreyfuchsreaction

[fhrątzLAB @fhratzlab]

🤩 We love it, and we use it in our lab!

[Chemistry World @ChemistryWorld]

‘When I was a student, textbooks were very dry. They contained very few diagrams, very few pictures and lots of text,’ explains Catherine Housecroft.

https://t.co/RVSNKrZXOv

[fhrątzLAB @fhratzlab]

@AbbensethJosh @chemieverband Lovely Schlenks🥹🤩

[fhrątzLAB @fhratzlab]

🫨Mechanochemistry strikes again! Me and
@dokkaebigirl continue our adventures with heterocycles in collaboration with Patrycja Żak's research team!
https://t.co/kccVFB7Ytd

[fhrątzLAB @fhratzlab]

📢 See our new paper with @drFhratz and @NataliaPietra14 in Advanced Synthesis and Catalysis @AdvPortfolio!
💡 This work is another collaboration with the team of Patrycja Żak (including Kamil Hanek)!

[Center for Advanced Technologies (CAT) @czt_uam]

📢 See the new paper titled "Solvent- and Transition Metal-Free Mechanochemical Synthesis of 2-Thiazolines and S-Thiocarbamates" just published in Advanced Synthesis & Catalysis @AdvPortfolio!
📲 https://t.co/f2idQrXtHj

👩🏻‍🔬🧑🏻‍🔬This work is another fruitful collaboration between the group of Dr. Hab. Patrycja Żak (including Kamil Hanek, MSc; Faculty of Chemistry, @UAM_Poznan) and @fhratzlab @czt_uam (led by Dr. Dawid Frąckowiak @drFhratz and including Natalia Pietras, MSc @NataliaPietra14). Kamil and Natalia thoroughly carried out all experimental work.🧪

#thiols #mechanochemistry #HeterocyclicChemistry

[fhrątzLAB @fhratzlab]

🤩 Thank you, @FredLamaty, for such wonderful conference!

[Center for Advanced Technologies (CAT) @czt_uam]

🤩 From June 4 to 6, 2025, the @fhratzlab @czt_uam team (Dr. Dawid Frąckowiak @drFhratz, MSc Barbara Kaczmarek @dokkaebigirl, and MSc Natalia Pietras @bluecookies4u) traveled to Montpellier, France!

💡 The researchers participated in the 𝗠𝗲𝗰𝗵’𝗰𝗵𝗲𝗠 𝟮𝟬𝟮𝟱: 𝗡𝗲𝘄 𝗳𝗼𝗿𝗰𝗲𝘀 𝗶𝗻 𝗠𝗲𝗰𝗵𝗮𝗻𝗼𝗰𝗵𝗲𝗺𝗶𝘀𝘁𝗿𝘆 conference, which was organized at @IBMM_Balard by @FredLamaty. The event was entirely dedicated to mechanochemistry!

🧐 The conference trip was financed by @UAM_Poznan Excellence Initiative-Research University program.

[Dawid Frąckowiak (dr Fhrątz) @drFhratz]

😍🤩 French academic-level chemistry textbooks (written by French authors) are on a completely different level compared to those in Poland!

[fhrątzLAB @fhratzlab]

@vylelab Thank you! 🥹😊

[fhrątzLAB @fhratzlab]

🤩🥳 Try to find us!
🤓 Conference Mech’cheM 2025: New Forces in Mechanochemistry at @IBMM_Balard has fully warmed up!

[fhrątzLAB @fhratzlab]

🧐 Here we go!
💪The Mech’cheM 2025: New forces in Mechanochemistry conference starts today!

[fhrątzLAB @fhratzlab]

The fhrątzLAB team on the way to Montpellier – stopover: Amsterdam!🌿😃

[fhrątzLAB @fhratzlab]

💡Yesterday, Dawid gave a lecture titled 𝘈 𝘚𝘤𝘪𝘦𝘯𝘵𝘪𝘴𝘵 𝘰𝘯 𝘚𝘵𝘢𝘨𝘦: 𝘏𝘰𝘸 𝘵𝘰 𝘛𝘢𝘭𝘬 𝘈𝘣𝘰𝘶𝘵 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘌𝘧𝘧𝘦𝘤𝘵𝘪𝘷𝘦𝘭𝘺 𝘢𝘯𝘥 𝘏𝘢𝘷𝘦 𝘍𝘶𝘯 𝘋𝘰𝘪𝘯𝘨 𝘐𝘵 at the 2nd Doctoral Symposium in Exact Sciences in Ciążeń.

[fhrątzLAB @fhratzlab]

🧐 Check out the latest paper, where we were invited to collaborate with the team of Prof. Dr. Eng. Wiktoria Suchorska from @wcopoznan!

[Center for Advanced Technologies (CAT) @czt_uam]

📢 Check the new paper titled 𝘐𝘮𝘱𝘢𝘤𝘵 𝘰𝘧 𝘴𝘰𝘧𝘵 𝘵𝘪𝘴𝘴𝘶𝘦 𝘩𝘰𝘮𝘰𝘨𝘦𝘯𝘪𝘻𝘢𝘵𝘪𝘰𝘯 𝘮𝘦𝘵𝘩𝘰𝘥𝘴 𝘰𝘯 𝘙𝘕𝘈 𝘲𝘶𝘢𝘭𝘪𝘵𝘺 published in Molecular Biology Reports from @SpringerNature!
📲 Link to the article: https://t.co/saV44TJ8uT

🧑🏻‍🔬👩🏻‍🔬The paper's co-authors are Dawid Frąckowiak @drFhratz, Barbara Kaczmarek @dokkaebigirl, and Natalia Pietras @bluecookies4u.

🫨🥶 One of the most fascinating practical challenges during the research was the cryogenic ball milling of tumor tissues (obtained from human skin)!

🧐 The article was created in collaboration with the team of Prof. Dr. Eng. Wiktoria Suchorska (head of the Radiobiology Laboratory at @wcopoznan in Poznań), initiated by Bartosz Maćkowiak (MSc) the corresponding author.

👩🏻‍🔬🧑🏻‍🔬 The other authors are Julia Ostapowicz, Kamila Ostrowska, Magdalena Fundowicz, Katarzyna Kulcenty, and Wojciech Golusiński.

[fhrątzLAB @fhratzlab]

🧑🏻‍🔬 🤩 On April 23, @drFhratz visited the Faculty of Chemistry at the @unilodz, where he gave a lecture for PhD students from the Doctoral School of Exact and Natural Sciences.

[fhrątzLAB @fhratzlab]

📅 On March 20th, @drFhratz gave a lecture at the 16th Science Festival at Charles de Gaulle Secondary School Complex No. 2 in Poznań Krzesiny!

🫨 The lecture "MECHANOCHEMISTRY: From Mortar and Pestle to Solvent-free Drug Synthesis" sparked great interest among the students!

[fhrątzLAB @fhratzlab]

🥳 We're happy that, thanks to ID-UB AMU funding, we can attend 𝗠𝗲𝗰𝗵’𝗰𝗵𝗲𝗠 𝟮𝟬𝟮𝟱: 𝗡𝗲𝘄 𝗙𝗼𝗿𝗰𝗲𝘀 𝗶𝗻 𝗠𝗲𝗰𝗵𝗮𝗻𝗼𝗰𝗵𝗲𝗺𝗶𝘀𝘁𝗿𝘆 in Montpellier! 🧑🏻‍🔬👩🏻‍🔬👩🏻‍🔬The travel team is @drFhratz , @dokkaebigirl, and @NataliaPietra14!

[Center for Advanced Technologies (CAT) @czt_uam]

📢 We cordially invite you to the lecture of Prof. Jamie Lewis @LewisChemistry from @UoBChemistry @unibirmingham!

📑 Lecture title: 𝘓𝘰𝘸 𝘚𝘺𝘮𝘮𝘦𝘵𝘳𝘺 𝘔𝘰𝘭𝘦𝘤𝘶𝘭𝘢𝘳 𝘊𝘢𝘱𝘴𝘶𝘭𝘦𝘴
📅 Tuesday, April 15th, 2025
🏢 Room D111.3 (1st floor)
⏰ 11:00

[fhrątzLAB @fhratzlab]

🔵 Natalia @bluecookies4u works with anhydrous CoCl2, which is always a treat to look at 🥹🤩

[Dawid Frąckowiak (dr Fhrątz) @drFhratz]

📢 The journal *Scientific Reports*, published by Springer Nature, has been criticized for publishing fraudulent studies in an open letter signed by numerous well-known experts in scientific fraud. 📲 Link to the letter: https://t.co/Is5XMEdnwb

📑 Citing @ChemistryWorld: "Since 2014, 25 articles in Scientific Reports have been flagged for containing tortured phrases. Over the same period, 262 articles have been retracted by the journal, according to a database managed by Retraction Watch, which records why papers are retracted. ‘They’ve published 23k papers in 2024 with article processing charges of £2090, raising £49 million from this journal alone,’ says Bishop. ‘So they should be able to put resource into cleaning this up.’"

https://t.co/vNtdPTYirn

[Center for Advanced Technologies (CAT) @czt_uam]

📢 💪 ERC laureates from @czt_uam are fighting to stop starvation of the @NCN_PL! Stay tuned for the press briefing today at 2:30 pm with @RozaSzweda and the interview with Kinga Kamieniarz-Gdula @STOPlabPI together with @AnnaZablocka aired later this week in @Radio_TOK_FM