FiorilloLab

Principal Investigator at Children's National Medical Center. Our lab focuses on dysregulated miRNAs in DMD and other muscle disorders.

[The Heier Laboratory @TheHeierLab]

Our new paper is out!
Vamorolone improves disease and increases dystrophin in our Becker muscular dystrophy model.
Now in clinical trials (NCT05166109)
#MuscularDystrophy #Becker #dystrophin
@FiorilloLab @MDAorg @ParentProjectMD @nih_nhlbi @iScience_CP
https://t.co/niTwAh3zyy

[Children's National Hospital 🏥 @ChildrensNatl]

Test your muscular dystrophy knowledge: Which muscles are sick and how do you know? #MedEd #MedTwitter

[Alyson Fiorillo, PhD @AlysonAFiorillo]

I am so excited to share our newly published work on generating and characterizing the first mouse model of #Beckermusculardystrophy @MacGyver0282 @TheHeierLab @nikkimmccormack @EdgewiseTx @FiorilloLab #duchennemusculardystrophy #dystrophin https://t.co/AJ1ZNNpcN4

[FiorilloLab @FiorilloLab]

@AbigailMackey1 "Weird stuff" 😂

[FiorilloLab @FiorilloLab]

Hey #ScienceTwitter; is there a circRNA array/sequencing company/platform that you recommend? And are there any companies out there that synthesize custom cirRNAs?

[Joy Wu, MD, PhD @JoyYWu]

With our publication in @NatureMedicine on pandemic-related barriers to the success of women in research, I’d like to shine a spotlight on gender equity for women physician-scientists, who face cumulative barriers imposed in medicine AND science https://t.co/7TlbyIsHAp 1/n

[Prof. Toshi Yokota PhD FCAHS @MD_Canada Res Chair @ToshifumiYokota]

Harry's review article "Casimersen for Duchenne muscular dystrophy" is featured in the latest issue of #DrugsofToday @clarivate, summarizing the preclinical and clinical data currently available for casimersen, emphasizing pharmacokinetics and safety. @WCHRIUofA @UAlberta_FoMD

[Matthew S. Alexander @Matt_Muscle_Guy]

Interesting new @Nature paper. MicroRNA sequence codes for small extracellular vesicle release and cellular retention. 🤯

https://t.co/wQnGFJdN4s

[Jyoti K Jaiswal @jyoti_k_jaiswal]

A pleasure to see that the @journal_nd special issue celebrating Terry Partridge’s contributions to muscle research and mentorship is out. https://t.co/lBhKoYVsm0 Thanks Raju for co-editing, @LochmullerLab, @JenniferEMorgan, Carsten and JND team for help and Pete Zammit for👇

[Elsevier News @ElsevierNews]

A new study, co-authored by @ElsevierConnect's @mehmanib et al. reveals the #gendergap got wider, while paper submissions grew at the start of the #COVID19 pandemic: https://t.co/rY0iMIDMHT #genderinresearch #researchworkforce #WomenInSTEM

@squazzoni @LaStatale @PLOSONE

[FiorilloLab @FiorilloLab]

@davidjglassMD I very much miss the Molecular Mechanisms of Muscle Wasting during aging and disease in Ascona, and I hope it will be back soon. Great atmosphere for connecting with other scientists, and the view isn't too bad either!

[Jyoti K Jaiswal @jyoti_k_jaiswal]

Together with Isabelle Richard @GenethonFr we describe a mouse model that mimics #LGMD2L muscle symptoms, offers insights into the basis of this disease, and test potential therapies https://t.co/JF5hwRkVbI.

[FiorilloLab @FiorilloLab]

First R01 is being reviewed (or not reviewed) in study section today. It's totally normal to refresh my ERAcommons every hour, right?😬

[Prof. Toshi Yokota PhD FCAHS @MD_Canada Res Chair @ToshifumiYokota]

50 free copies of our article are available below!: Restoration of dystrophin expression and correction of #Duchenne muscular dystrophy by genome editing https://t.co/MpZWQuIu80 @tandfonline @UAlberta_FoMD
#CRISPR

[Who Really Cares? @TheParentCarer]

This.

If I had continued in the cure mindset for my son’s Duchenne diagnosis, I would have wasted 7.5 years of his life so far being unhappy.

Accept and adapt. Let it go. Move forward. Smile.

#Duchenne #DMD #Disability

[Davi Mazala @DaviMazala]

Happy that our paper has been published!
Human muscle stem cells are refractory to aging https://t.co/fGg1MCkIXS

[Prof. Toshi Yokota PhD FCAHS @MD_Canada Res Chair @ToshifumiYokota]

Delighted to co-host the new Research Topic "Genome and Transcriptome Editing to Understand and Treat Neuromuscular Diseases" with @RikaMaruyama_E @AlysonAFiorillo @MacGyver0282 and Dr. Duan in Frontiers in Genome Editing
@FrontGenEditing
https://t.co/Zt5JN9mA6j #CRISPR