Fernanda Manieri, PhD 🇧🇷☣

☕🦉 Coffee lover & birdwatcher.
Salmonella | Virulence | Transcriptomics | Genomics | Antimicrobial resistance | PhD in Biosciences | Professor @ UNIFAL

[Science Magazine @ScienceMagazine]

Some bacteria that are harmful to humans escape elimination by antibiotics because they carry resistance genes. However, antibiotic-susceptible bacterial populations often harbor rare persister cells that survive antibiotic exposure without being resistant. Antibiotic persistence favors recurrent infections and resistance emergence and is a public health threat.

Persister cells are thought to be metabolically dormant. Decreased activity of antibiotic targets would enable them to remain alive when antibiotics are present and to regrow after antibiotic removal.

In a new Science study, researchers report that Escherichia coli persister cells do not simply enter a dormant state upon antibiotic treatment. Instead, genetically identical cells diverge into two physiological states.

Some cells produce membrane vesicles that are loaded with specific proteins, which are taken up by other cells to enhance survival. Therefore, vesicle donors and recipients actively cooperate to benefit the entire bacterial population.

Learn more in a new #SciencePerspective: https://t.co/be5JNwqHJa

[Nature Reviews Microbiology @NatureRevMicro]

New online! Fermented food microbiome: influence on oral and gut microbiota, and human health https://t.co/CvVqyUAwMS

[Luke Turner 🦠 @MicroLukas]

Damn that MexAB-OprM 😢

https://t.co/buUhd4xTwQ

@LondonUmejiaku

[Fernanda Manieri, PhD 🇧🇷☣ @freakfer]

Emerging pathogens in urinary tract infections: virulence and phenotypic characterization of Pseudomonas aeruginosa strains | mSphere https://t.co/ph1ivNu1t3

[Cell Host & Microbe @cellhostmicrobe]

UPEC subverts neutrophils

Uropathogenic E coli regulatory system DanRI is induced by nucleosomes present in NETs. DanRI regulates broad cellular responses and dampens neutrophil responses by attenuating reactive oxygen species production & NET formation
https://t.co/ED9lVN4DET

[ASM @ASMicrobiology]

#MicrobiologyMonday: S. aureus has been observed within nanoscale channels in bone that are 2–3 times smaller than its own diameter. How does it get there? Fluid pressures in the body may help transport the bacteria into bone. Learn more in #mBio: https://t.co/dOmqpZPKRV

[ASM @ASMicrobiology]

Enterococcus faecalis not only antagonizes Pseudomonas aeruginosa growth under iron limitation, but also induces a unique transcriptional profile, enhancing P. aeruginosa survival during antibiotic challenge. Learn more in #JBacteriology: https://t.co/wcMQXBh43E

[Cascales Lab @CascalesLab]

T2SS ? T4SS ? CDI ? T6SS ? T7SS ?
NO ! The #T9SS is also involved in interbacterial competition !! @CurrentBiology

Great work by Maelle Paillat @maelle_paillat under the supervision of Thierry Doan @doan_thierry

https://t.co/yNTxTeTar9

[Trends in Microbiology @TrendsMicrobiol]

Interspecies competition promotes antibiotic resistance with diminishing returns https://t.co/II2yoI4CBs

[ASM @ASMicrobiology]

UPEC experiences copper stress during UTI, and resistance to copper is critical for UPEC virulence. Researchers discovered that long-chain fatty acid homeostasis contributes to survival and virulence of UPEC during copper toxicity. #JBacteriology: https://t.co/3zktei6LzL

[Prof Brajesh Singh @Prof_Braj_Singh]

Our new paper in @cellhostmicrobe include
1. a global atlas of human bacterial pathogens in soils
2. Soil biodiversity negatively linked with human pathogens
3. Many pathogens to increase in future climates
4. Positive link between pathogens & mortality
https://t.co/RKcZPGJG5A

[Cell Host & Microbe @cellhostmicrobe]

UPEC subverts neutrophils

Uropathogenic E coli regulatory system DanRI is induced by nucleosomes present in NETs. DanRI regulates broad cellular responses and dampens neutrophil responses by attenuating reactive oxygen species production & NET formation
https://t.co/ED9lVN4DET

[Wataru Hayashi / 林 航 @DraWataru]

The mechanisms of antibiotic resistance and drug resistance transmission of Klebsiella pneumoniae | The Journal of Antibiotics

(https://t.co/2CfLkpTdpK)

[Olivier Borkowski @O_Borkowski]

A global soil plasmidome resource unveils functional and ecological roles of plasmids in soil microbiomes
https://t.co/TlNS7BZqyw

[Nature Microbiology @NatureMicrobiol]

Plasmids promote antimicrobial resistance through insertion sequence-mediated gene inactivation https://t.co/7Wer6JmqaW #MicroSky

[Uli Klümper @UliKluemper]

New paper in Environmental Science & Technology 🧪

“Antibiotics or Heavy Metals in Livestock Wastewater: Which One Is the Main Driver for the Development and Spread of Antibiotic Resistance under Coexposure?”

Led by Jin Huang and Bing Li.

https://t.co/EVS7jDI291

[Cell Host & Microbe @cellhostmicrobe]

Featured Article: Microbiome signature of health

Global analysis of 11,000 microbiomes reveals uncultured bacteria as markers of gut health. Uncultured genus CAG-170 linked to low dysbiosis & vitamin B12 production & plays ecological roles in healthy gut
https://t.co/BAPQtqvPUA

[Tominaga K. (tomiken) @pacyc1841]

High-quality metagenome assembly from nanopore reads with nanoMDBG | Nature Communications https://t.co/SpeR7kUaqQ

[mBio @mbiojournal]

Microbe vs. microbe: a DNA‑releasing showdown. New #mBio study finds that #Streptococcus mitis uses targeted #bacteriocins to burst S. pneumoniae cells, releasing DNA and boosting gene exchange, revealing a surprising mechanism shaping bacterial evolution. https://t.co/AeOkE9Mf5H

[good papers @paperperday]

High bacterial diversity drives the suppression of a soilborne plant disease

"the diversity of synthetic communities per se can provide plant health benefits through an increased ability to protect against pathogens."
https://t.co/a8PEtnSzIp