SalvajeDesterrado

Snake-eater

[Abud Bakri MD @AbudBakri]

I think TSH will be shown to be a key regulatory of sleep

And I predict it’s doing it by competitive inhibition of MSH receptors

Treating hypothyroidism leads to faster tanning. Suppressing TSH to 0 leads to crazy fast tans as if you’re on Melanotan

MSH receptors mediate wakefulness

TSH and MSH regulate tyrosine metabolism. Melanin and thyroxine

[Nick Jikomes @trikomes]

You need to be lipid peroxidation minning.

[LJB | Sage of Hoeflation | POFMA Poet | COE/GCB @hoeflator]

Reducing your wife's heavy metal load and ensuring she's progesterone dominant when conceiving and gestating is what allows the best epigenetic expression and to create a high IQ child. It's as simple as that really. Of course you'd like her to be intelligent as well but as most of my followers are cryptobros I can't expect too much.

[Abud Bakri MD @AbudBakri]

Remember they don’t know how many of these chronic diseases have mitochondrial origins/contributions

They will soon find out

[Hyde 💨 @BreatheLesss]

Almost there! A resource page for the basics of the Buteyko method.

[du @thedulab]

You're either "passionate" about the thing you do, or "passionate" about what the thing can do for you

In other words, you either love the process, or love the end result more, which allows you to adopt a more enjoyable perspective of the process

Quick way to gauge which one you are is to imagine your ideal end result. Are you decades older, looking at what you've built, and feeling immense pride from it being your life's work?

Or is it more of this idea of being financially set, having time freedom, and crafting a reality where you can't be bothered?

Which one gets you more high? Does a Sam Altman type inspire you more, or the anon who got rich off crypto and now is able to do whatever he wants?

Both are justified. Both are admirable and worthy to the specific beholder. But what's important is just not larping about whatever you choose

Too many people are completely misaligned on this front out of well intentioned ignorance. You can be internally driven or externally driven. Want to change the world or change your world. There's no blueprint for what's right or wrong, should or shouldn't

Only you know. Never let anyone pysop you out of your gut feeling. Just have to lean into and accept whatever that is. It's your life. Don't regret it

[Zaid K. Dahhaj @zaidkdahhaj]

The way red and NIR light diffuses throughout the body has always been incredibly fascinating to me

Water captures that infrared light, which means the blood vessels can capture that diffused light and send it to other areas of the body

Even if you use photobiomodulation exclusively on your shins, that session will also benefit other organs as a result of this phenomenon

The implications of this cannot be understated when you also consider that every mitochondria uses red and NIR light for energy production via Complex V of the electron transport chain

We now know that there are cell-free floating mitochondria in our blood

To the tune of between 200,000 and 3.7 million cell-free intact mitochondria per mL of plasma

I first learned about NIR diffusion from @RogerSeheult

[Fez☯️🐸 @Zenfrog4]

Is there a relationship between skin pigmentation, cochlear melanocytes, and hearing loss?

Studies indicate darker-skinned individuals tend to have more internal melanin, including in the inner ear, which may protect from tinnitus and hearing loss.

It is theorized that Melanocytes may have antioxidant functions that protect against reactive oxygen species associated with the death of inner ear hair cells in noise-induced hearing loss.

For instance, an 80-year-old male with presbycusis and noise-induced hearing loss showed abundant melanin in the middle cochlear segment and minimal melanin in the basal segment - indicating a potential link to reduced oxidative protection at the cochlear base [1]:

The Role of Potassium and Melanocytes in Hearing
Potassium ions and endolymph are essential for maintaining the proper function of cochlear melanocytes and facilitating hearing.

Cochlear melanocytes regulate high levels of potassium ions in the endolymph, vital for hair cell function in detecting sound vibrations.

Hair cells convert these vibrations into electrical signals, enabling the brain to perceive sound.

Potassium ions contribute to generating these electrical signals within hair cells, aiding in the transmission of auditory information along the auditory nerve.

Endolymph, rich in potassium ions, fills the scala media, facilitating the movement of sound waves and stimulating hair cells, ultimately leading to the transmission of auditory signals to the brain [2].
But are cochlear melanocytes all that matter when it comes to hearing?

In the studies below, there was no relationship between skin pigmentation or eye color and the perception of hearing loss or tinnitus, suggesting that the role of melanocytes in hearing may be more complex than previously thought.

Study 1: "Skin Pigmentation and Risk of Hearing Loss in Women"
The study utilized a prospective cohort design among 49,323 white women from the Nurses’ Health Study to investigate the relationship between skin pigmentation and the risk of hearing loss.

Surrogate measures of skin pigmentation, including hair color, skin tanning ability, skin reaction to prolonged sun exposure, and Fitzpatrick skin phototype were assessed.

Despite analyzing 1,190,170 person-years of follow-up (1982–2012), they found no association between the risk of hearing loss and any of these surrogate measures for skin pigmentation, prompting a reconsideration of the role of cochlear melanocytes in this context [3].

Study 2: "The Role of Eye Color in the Emergence of Tinnitus in Silence Study"
In this study, researchers aimed to evaluate the connection between eye color, indicative of non-cutaneous melanin levels, and the occurrence of temporary tinnitus during a brief period of silence.

They conducted a cross-sectional analysis involving adults categorized by eye color who were exposed to 10 minutes of silence, followed by a questionnaire to report any perception of sounds in the ears or head.

The results showed that while 63% of participants perceived tinnitus during silence, there was no significant association between eye color or race and the perception of tinnitus, suggesting that further investigation is needed to understand the role of melanin in tinnitus emergence [4].

Conclusion
Considering the lack of consistent associations between skin pigmentation, eye color, and the risk of hearing loss or tinnitus in recent studies, particularly among white individuals, the presumed link between cochlear melanocytes and auditory function warrants reevaluation.

Despite previous hypotheses suggesting that melanocytes' antioxidant properties might mitigate the effects of oxidative stress in hearing loss, recent evidence challenges this notion.

Therefore, further investigation is necessary to elucidate the role of cochlear melanocytes in auditory health and the potential mechanisms underlying hearing loss and tinnitus.

[Hyde 💨 @BreatheLesss]

It's crazy how TCM has been able to accurately develop, predict, and highlight things that modern science is now discovering. By using seemingly outdated concepts and frameworks like meridians or the three treasures, etc the Taoist health practices very often surprise me with their precision.

[Noah Ryan @NoahRyanCo]

GABA compounds have done more for my focus than stimulants.

- Taurine
- Glycine
- L-Theanine
- Lemon Balm
- Apigenin

Overstimulation is just as detrimental as understimulation

Sometimes you need less brain activity, not more.

[Fez☯️🐸 @Zenfrog4]

It's your civic duty as an altruistic member of society to know all about Leptin and POMC

And to explain their importance at a 1st-grade level when asked.

Here is everything you need to know🧵

[Chris Masterjohn @ChrisMasterjohn]

Salt is good for you.

[☁️𝓕 @fillefoux]

a lot of people aren’t even neurodivergent they’ve just destroyed their natural dopamine pathways via addiction (internet, porn, substances) and their social skills have really eroded bc of isolation

[anabology @anabology]

High testosterone is associated with a longer life¹ but anabolic steroid usage is associated with worse mortality than cigarettes.²

Progesterone is one of the most anti-cancer hormones³ but synthetic progestins are associated with breast cancer.⁴

When received from the medical establishment, synthetic progestins are often labeled “progesterone,” which is factually untrue.

The nature of hormones is extremely sensitive to small structural changes, and their effects cannot be fully explained through their receptor interactions.

Modern science equating synthetic hormones to endogenous hormones is a failure of 'receptor biology' -- the idea that molecules exert their actions through receptors. A synthetic analog to progesterone activates the progesterone receptor, so it must be the same as progesterone, according to modern science.

This is far from the truth.

Some relevant history:

Cells have an electrical potential, which means there is a difference in the concentration of charges on either side of the membrane. These charged particles are ions, such as potassium (K+) or sodium (Na+).

There has been nearly a century of fraud surrounding the membrane pump theory of cell regulation⁵, which is intimately related to receptor biology. The idea is fairly simple: cells will use the ‘sodium/potassium pump’ to pump out sodium ions and pump potassium in. With these pumps, they reach the resting state of the cell: high potassium, low sodium.

Gilbert Ling, in grad school (c. 1940s) did the math: there was not enough energy in the cell to operate these pumps by an order of magnitude. While there may be a pump, it cannot account for all of the sodium/potassium flux. Despite this simple fact, the newest generations of scientists and medical students are still taught that the sodium/potassium pump regulates the membrane potential.

Gilbert Ling’s idea was that proteins change state when binding or releasing ‘adsorbents:’ ATP, hormones, H+, or example. Depending on state, they structure water differently, allowing them to either bind to or release potassium or sodium. The membrane was not seen by Ling as impermeable, so the ion flux could entirely be explained by protein state intracellularly.

There is a class of compounds called “cardiac glycosides.” One of the most well known cardiac glycosides, ouabain, is known to mainstream science as an inhibitor of the sodium/potassium pump, because it increases intracellular sodium. This mechanism is inconsistent with Ling’s hypothesis.

If not a sodium pump inhibitor, Ling needed to prove an alternative mechanism of ouabain for his model to work. Ling showed that ouabain can exert all of its same effects without the presence of sodium pumps: as in, it directly interacts with proteins (not its specific ‘target’) to change their state and make them prefer sodium more/potassium less.

How is this relevant to hormones?

If we look at the structure of cardiac glycosides, all of them are steroids.

Steroids, like cholesterol, testosterone, or progesterone, have a unique structure that lets them (in Ling’s view) act as cardinal adsorbents — binding to proteins and modulating the protein state, thereby changing the structure of water intracellularly.

Back in the 1970s, Raymond Damadian, following Ling’s work, noticed that cancer cells have a different water structure than healthy cells: the water is more liquid and less ice-like (the NMR T1/T2 relaxation times are shorter)⁶. Following these discoveries, Damadian postulated that you could scan the human body with an NMR instrument and detect cancer.⁷ Thus, he invented the MRI machine.

Albert Szent-Georgi took a probe that was phosphorescent in ice and not phosphorescent in liquid water and put it in muscle cells.⁸ In a resting state, the probe was visible, because the water was ice-like. When the cells were stimulated with electricity, the probe turned off - indicating that the water was now more bulk fluid-like, and less ice-like.

We now know that senescent cells have a ‘diluted’ cytoplasm, being more like bulk liquid water versus ice.⁹

The resting state of cell water is structured and ice-like. The active, stimulated state of cell water is more fluid, like bulk-phase water. In the resting state, proteins prefer potassium. In the active state, they exclude potassium and allow sodium in. Cancer and senescent cells could be considered to have their water stuck in the 'active' state.

The calming hormones (progesterone, for example) may facilitate the ice-like structure of intracellular water, without any direct interaction with hormone receptors. Cardiac glycosides are evidence of this. With a ‘hormonal’ (steroid) structure, and without direct hormone receptor interactions, and without a need for the sodium pump, they lead to an altered potassium/sodium balance in the cell.

This is why altering single groups on hormones leads to wildly different effects. They do not act at the receptor level - they act on cell water. Changing a single atom can radically change the hydrophilicity/hydrophobicity of the hormone. You can therefore have a progestin that binds and activates the progesterone receptor, but may structure the cell water in the same way estrogen does. A bastard child of hormones.

If you want to supplement hormones, you probably should use the bioidentical versions.

[HUX @myconautic]

People take drugs to achieve the feeling of what optimal gut health feels like.

[Chris Masterjohn @ChrisMasterjohn]

The term “glycation” sounds like it is caused by sugar, but this is extremely misleading.

A thread 🧵👇

[BowTiedNeuron | Neuroscientist @BowTiedNeuron]

Gm☀️

[Noah Ryan @NoahRyanCo]

417 hz & BPC 157 kind of night

The esoteric & scientific are not mutually exclusive, but rather synergistic

Avoid dogma