Ora Furman Lab 🎗

Structural basis of peptide-mediated protein communication and function @HebrewU Member of @RosettaCommons. Tweets by lab members.
🦋 🦋

[Ora Furman Lab 🎗 @FurmanLab]

AlphaFold3 is out (and closed source 🤯😠)! So … how well does it do on peptide-protein complexes?

A continuing thread as we run predictions...

[Ora Furman Lab 🎗 @FurmanLab]

🦋 Find us also on bluesky 🦋
https://t.co/0wZZ8i0j3J

[Ora Furman Lab 🎗 @FurmanLab]

Try it and let us know how it goes!
@BenLehner @xiaotianliao @sokrypton @amoseslab

[Ora Furman Lab 🎗 @FurmanLab]

🚨 actifpTM is now in AF3 🚨

Since our new metric, actifpTM, was determined to be the best for predicting success in designed proteins refolded by AF2 (https://t.co/JHCubdsD7i by @TimothyPJenkins), we made it available also in AF3!

[Ora Furman Lab 🎗 @FurmanLab]

Our work on refining AlphaFold2’s ipTM has been accepted for publication in Bioinformatics @OxfordJournals
We have been questioning why ipTM worsens when docking peptides with disordered flanking regions, and modified the calculation to remove this effect.

Let’s dive in! 👇

[Ora Furman Lab 🎗 @FurmanLab]

If you want to integrate it in your own AF3 installation, check the 3 files which only need a slight modification (https://t.co/XxueOWUzi0, https://t.co/MNPYuEZ3zi and confidence_types.py):
https://t.co/BdOxAm5MT1

[Clay Kosonocky @kosonocky]

🚨The Bits to Binders Competition has concluded!🧬

One year ago we gathered scientists from around the world to design and submit protein binders that cause immune cells to target and eliminate CD20+ tumors

Spoiler: They work!

[GAMA Miguel Angel 🐦‍⬛🔑 @miangoar]

1/13 🧵 Today, Bindcraft was published in @Nature , one of the most famous AIs in biology for designing protein–protein interactions (PPI). In my opinion. Bindcraft represents one of the most important advances in the post–AlphaFold2 era.

[Martin Pacesa @MartinPacesa]

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

[Ora Furman Lab 🎗 @FurmanLab]

5/
This was an amazing collaboration with the @lab_wiener and @RouvinskiLab - thank you! 🙌
Graphical abstract below ⬇️
#SARSCoV2 #COVID19 #Virology #CellReports #ComplementSystem #Immunology

[Ora Furman Lab 🎗 @FurmanLab]

1/
🚨Excited to share our new work in Cell Reports!
We reveal how SARS-CoV-2 nucleocapsid protein (NP) directs complement attack on uninfected cells, a surprising immune evasion twist.
🔗 https://t.co/FusTs1cxYM

[Ora Furman Lab 🎗 @FurmanLab]

4/
💡 Heparin analogs (like Enoxaparin) block NP surface binding, preventing immune complex formation and rescuing cells from complement attack.
A possible path to reduce immunopathology.

[Tomer Tsaban @TomerTsaban]

Our paper is out on biorxiv! Very excited to share our results - we find signal peptides might be structurally important for quite a few protein isoforms. Full thread soon!

[Boston Protein Design and Modeling Club @ProteinBoston]

If you missed out on Sarel Fleishman's extraordinary talk last night, have no fear - you can check out the recording 👇
https://t.co/w2SdNFfpoK

[Ora Furman Lab 🎗 @FurmanLab]

Starts in 10 minutes! This will be exciting, join us!

[PMC Protein Modules Community @PMC_modularity]

Join us at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute) and Dr. Jesús Alvardo Valverde (@imbmainz).

Register to attend: 

https://t.co/Q1p4rEl8eC 

(1/2)

[Ora Furman Lab 🎗 @FurmanLab]

Come join for this exciting talk!

[PMC Protein Modules Community @PMC_modularity]

Remember to tune in at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute) and Dr. Jesús Alvarado-Valverde (@imbmainz).

Register to attend: 

https://t.co/Q1p4rEkAp4

[PMC Protein Modules Community @PMC_modularity]

Remember to tune in at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute) and Dr. Jesús Alvarado-Valverde (@imbmainz).

Register to attend: 

https://t.co/Q1p4rEkAp4

[Ora Furman Lab 🎗 @FurmanLab]

@lab_wiener Congratulations to all!

[Julia Varga 🇭🇺 🇪🇺 @jvarga92]

Either if you attended or wanted but could not - please tell us how it works for you!