Gareth Ball

neuroscience, brain development, data. the odd beer.

[cedric boeckx @cedricboeckx]

Great study by @garedaba @StuartJoldham @jakob_seidlitz and colleagues, linking molecular and anatomical descriptions of the prenatal brain, now out in @NatureComms:
Molecular signatures of cortical expansion in the human foetal brain 🧠🧬
https://t.co/2GknMOSQEI

[Sila Genc @drsilagenc]

🧠New pre-print🧠

In this work we study cortical neurite and soma architecture over development using ultra-strong gradient dMRI 🧲

MRI signatures of cortical microstructure in human development align with oligodendrocyte cell-type expression: https://t.co/oVBJRXunoy

[bioRxiv Neuroscience @biorxiv_neursci]

Causal Cortical and Thalamic Connections in the Human Brain https://t.co/kQQQzWmmr2 #biorxiv_neursci

[bioRxiv Neuroscience @biorxiv_neursci]

The developing Human Connectome Project fetal functional MRI release: Methods and data structures https://t.co/aAOJbzT0b3 #biorxiv_neursci

[Borrell Lab @BorrellLab]

Gene regulatory landscape of cerebral cortex folding | Science Advances https://t.co/ykzkbGo5eg

[bioRxiv Neuroscience @biorxiv_neursci]

Spatial Single-cell Analysis Decodes Cortical Layer and Area Specification https://t.co/a4MkFTh9Pl #biorxiv_neursci

[Michelle Monje 🟦 @michelle_monje]

Neurofibromatosis (#NF1) is a neurogenetic syndrome associated with learning impairments and a predisposition for glial tumors. We find that NF1 mutation causes an intrinsic deficit in oligodendrocyte precursor cell (OPC) differentiation. A thread 🧵 1/
https://t.co/kJP9eNAKpF

[Alan Wang @AlanQWang]

Introducing BrainMorph, a foundation model for general purpose brain MRI registration! BrainMorph is a robust tool that supports multi-modal, pairwise, and scalable groupwise registration via rigid, affine, and nonlinear transformations.

🧵1/5 👇 for code, models, and paper!

[CLaE @leafs_s]

Cerebral Cortex

meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition https://t.co/XYyptJ860b

[bioRxiv Neuroscience @biorxiv_neursci]

Spatiotemporal transcriptomic maps of mouse intracerebral hemorrhage at single-cell resolution https://t.co/oPn74ltjw6 #biorxiv_neursci

[Hu Zhao-- CIBR, Beijing @huzhao4]

A collaboration with my neighboring lab is on Biorxiv.
https://t.co/vvZ8wRhByt
Dr. Jianglai Wu designed a curved light sheet microscope for high-speed, large-volume imaging. He imaged an entire intact cleared mouse brain at a voxel size of 0.625 × 0.625 × 1.25 μm3 within just 3 hours, eliminating the need for image tiling. This significantly saves time and, when combined with PEGASOS tissue clearing, allows for mesoscale projectome mapping at an unprecedented speed.

[Zhiqiang Sha (@zhiqiangsha.bsky.social) @sha_zhiqiang]

A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex
https://t.co/YDw0EbCS8W

[Louise Huuki-Myers @lahuuki]

Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠
@LieberInstitute @10xGenomics #scitwitter
📰 https://t.co/NJWJ1mwB9J

[Jakub Kopal @KopalJakub]

New preprint explores how rare high-effect gene-coding variants (#CNVs) shape brain architecture and influence cognitive and socio-behavioral traits in adolescents (#ABCD).

https://t.co/GWznEYk7lo

[bioRxiv Neuroscience @biorxiv_neursci]

Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids https://t.co/Axu0xIAz6l #biorxiv_neursci

[PGC Consortium @PGCgenetics]

This recent GWAS preprint is the first to explore genetic influences on the age at onset of walking 🚶‍♀️🚶, a milestone that may indicate broader (neuro)developmental delays.

Find out more⤵️
https://t.co/MkzgEtKodl

[Jakob Seidlitz @jakob_seidlitz]

‼️We’re hiring! @CHOP_Research Seeking imaging/informatics folks and/or those passionate about human development/disease & imaging-genetics! Massive data sandbox (N>200k)! Highly collaborative & welcoming environment! DM/email or see us @OHBM @Aaron_A_B

https://t.co/kmOLT2ldJO

[bioRxiv Neuroscience @biorxiv_neursci]

Development of thalamocortical connectivity during the third trimester https://t.co/GZeETtgHkz #biorxiv_neursci

[Stuart Oldham @StuartJOldham]

Our preprint on thalamocortical connectivity in neonates is out!🧠👶 I'll do a summary later for those who have time to browse Twitter yet are too busy to read papers, but for now, I need a small break from thinking about this work😅#ittookovermylife
https://t.co/tK514lbixP

[Sergiu P. Pasca @Sergiu_P_Pasca]

Today, I’m thrilled have our lab’s work featured on the cover of @Nature

In this article, we have developed a therapeutic approach for a severe condition called Timothy syndrome. This has been a long journey. It started with making hiPS cell-derived neurons in 2D cultures 15 years ago when I was a postdoc and continued with later creating in the lab #organoid and then #assembloid models of this disease caused by a mutation in a calcium channel.

Over time, these human cellular models and the biological insights we gained enable us to design a therapeutic strategy, which we validated in vivo following circuit integration of patient-derived organoids into the rat brain.

Grateful for the incredible work led by @XiaoyuChenxy and @fikribirey in the lab! And the many close collaborators who participated to this line of research over the years.