Great study by @garedaba@StuartJoldham@jakob_seidlitz and colleagues, linking molecular and anatomical descriptions of the prenatal brain, now out in @NatureComms:
Molecular signatures of cortical expansion in the human foetal brain 🧠🧬
https://t.co/2GknMOSQEI
🧠New pre-print🧠
In this work we study cortical neurite and soma architecture over development using ultra-strong gradient dMRI 🧲
MRI signatures of cortical microstructure in human development align with oligodendrocyte cell-type expression: https://t.co/oVBJRXunoy
Neurofibromatosis (#NF1) is a neurogenetic syndrome associated with learning impairments and a predisposition for glial tumors. We find that NF1 mutation causes an intrinsic deficit in oligodendrocyte precursor cell (OPC) differentiation. A thread 🧵 1/
https://t.co/kJP9eNAKpF
Introducing BrainMorph, a foundation model for general purpose brain MRI registration! BrainMorph is a robust tool that supports multi-modal, pairwise, and scalable groupwise registration via rigid, affine, and nonlinear transformations.
🧵1/5 👇 for code, models, and paper!
A collaboration with my neighboring lab is on Biorxiv.
https://t.co/vvZ8wRhByt
Dr. Jianglai Wu designed a curved light sheet microscope for high-speed, large-volume imaging. He imaged an entire intact cleared mouse brain at a voxel size of 0.625 × 0.625 × 1.25 μm3 within just 3 hours, eliminating the need for image tiling. This significantly saves time and, when combined with PEGASOS tissue clearing, allows for mesoscale projectome mapping at an unprecedented speed.
New preprint explores how rare high-effect gene-coding variants (#CNVs) shape brain architecture and influence cognitive and socio-behavioral traits in adolescents (#ABCD).
https://t.co/GWznEYk7lo
This recent GWAS preprint is the first to explore genetic influences on the age at onset of walking 🚶♀️🚶, a milestone that may indicate broader (neuro)developmental delays.
Find out more⤵️
https://t.co/MkzgEtKodl
‼️We’re hiring! @CHOP_Research Seeking imaging/informatics folks and/or those passionate about human development/disease & imaging-genetics! Massive data sandbox (N>200k)! Highly collaborative & welcoming environment! DM/email or see us @OHBM@Aaron_A_B
https://t.co/kmOLT2ldJO
Our preprint on thalamocortical connectivity in neonates is out!🧠👶 I'll do a summary later for those who have time to browse Twitter yet are too busy to read papers, but for now, I need a small break from thinking about this work😅#ittookovermylife
https://t.co/tK514lbixP
Today, I’m thrilled have our lab’s work featured on the cover of @Nature
In this article, we have developed a therapeutic approach for a severe condition called Timothy syndrome. This has been a long journey. It started with making hiPS cell-derived neurons in 2D cultures 15 years ago when I was a postdoc and continued with later creating in the lab #organoid and then #assembloid models of this disease caused by a mutation in a calcium channel.
Over time, these human cellular models and the biological insights we gained enable us to design a therapeutic strategy, which we validated in vivo following circuit integration of patient-derived organoids into the rat brain.
Grateful for the incredible work led by @XiaoyuChenxy and @fikribirey in the lab! And the many close collaborators who participated to this line of research over the years.