Ted Satterthwaite

McLure II Associate Professor | University of Pennsylvania | Director, PennLINC | neuroimaging, neurodevelopment, neuroinformatics, & mental health

[Ted Satterthwaite @sattertt]

Ecstatic to see the RBC paper out!! MAJOR congrats to all-star first-author @goliashf. RBC has been an amazing collab between #pennlinc & @childmindinst, led with the inimitable @MilhamMichael. So many thx to the many many many collabs that made RBC happen.

[Golia Shafiei @goliashf]

(1/17) Now out on bioRxiv‼️Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | https://t.co/ZSymcPIJ7c

Funded by @NIMHgov

[Ted Satterthwaite @sattertt]

Postdoc opening w/ a great team inc close collab Dan Wolf! fMRI + computational modeling in NIH-funded clinical high risk for psychosis study. U. Maryland in collaboration with UPenn + Mt. Sinai. Full posting here: https://t.co/pF5T9E25Ni

[Ted Satterthwaite @sattertt]

So excited to see this fabulous work by stellar MD-PhD student @briana__macedo out as a preprint. Briana reports some of the strongest results I've ever seen -- very strong (25% variance, out-of-sample) associations between the childhood environment and white matter. 🧵

[Briana Macedo @briana__macedo]

How much does the childhood environment shape the brain?

In our new preprint, we study the exposome (300+ environmental exposures) and link it to white matter structure in 8,000+ kids. 🧠✨

Read here: https://t.co/OfIYsOuQdQ

🧵Thread below

[Ted Satterthwaite @sattertt]

Huzzah for @stevenmeisler.com, whose preprint on our new fully-processed ABCD dMRI data resource is now out. The super-clear results from this monumental effort will undoubtably change the way we approach studies of white matter development going forward.

[Steven Meisler @StevenMeisler]

Diffusion MRI (dMRI) is a powerful tool to study white matter maturation. In our new preprint, we process and distribute a new resource of >24,000 ABCD dMRI scans using open source tools! We then evaluate how methods shape inferences about development.
🔗 https://t.co/XzEFQQj6i9

[Ted Satterthwaite @sattertt]

Incredible work by the absolutely stellar Brooke Sevchick and @singletonion — the second installment of our open-science living meta-analysis of psychedelics for mental health; check out https://t.co/Fui5SuqW4y.

[Parker Singleton @singletonion]

🍄 Our second installment of https://t.co/ICdlySqJJl, a living systematic review and meta-analysis on MDMA for PTSD is now live on medRxiv. Here's what we found and how we built upon our open science infrastructure to support it 🧵

https://t.co/KSUPAKJdjW

[Ted Satterthwaite @sattertt]

Beyond delighted to see this paper -- our first from the SYPRES initiative -- now out at Nature Mental Health. Check out Parker's awesome explainer below, w/ links to dashboard + all code + data.

[Parker Singleton @singletonion]

🍄 Our first https://t.co/ICdlySqJJl living systematic review and meta-analysis on psilocybin for depression is out now in @NatMentHealth. Here's what we found and the open science infrastructure we built to support it: 🧵

Open-Access Link: https://t.co/PhU4tad8Q8

[Imaging Neuroscience @ImagingNeurosci]

New paper in Imaging Neuroscience by Remika Mito, Andrew Zalesky, et al:

TRAMFIX: TRavelling Across Melbourne for FIXel-based analysis (a reproducibility and reliability study)

https://t.co/pRJgXi6kAV

[Maxwell Elliott @max12elliott]

Are you interested in detecting brain changes in individuals with higher precision over shorter intervals?

Check out our new paper in @NatureComms. With @RandyLBuckner, @jingnandu049 and others

Link - https://t.co/o5NPDoHspY

[Bratislav Misic @misicbata]

Synaptome architecture shapes regional dynamics in the mouse brain | https://t.co/YKH3euIQpP

How do diverse synapses relate to the spatial patterning of whole-brain dynamics? @JustineYHansen explores @PLOSBiology ⤵️

[Ted Satterthwaite @sattertt]

Beyond delighted to see this awesome paper from superstar Audrey Luo now out. See her wonderful thread below re: two highly-replicable axes of white matter development in youth.

[Audrey Luo @audreycluo]

We think of white matter as highways of the brain. But when we followed development along those highways, we were surprised. The journey is more complex than we thought. My PhD paper, “Two Axes of White Matter Development”, is now out in @NatureComms!🧠

🔗https://t.co/qR3tyH0y90

[Caterina Gratton @GrattonCaterina]

One week left to apply!

[Bratislav Misic @misicbata]

1️⃣ A few years ago we released an in vivo chemoarchitectural atlas of group-average receptor maps (https://t.co/zpjnCsVayw).

What is the inter-individual variability in receptor density, and how does it vary of brain regions?

[Caterina Gratton @GrattonCaterina]

Just under 2 weeks left to apply! 👇

[dipy @dipymri]

Beyond excited seeing so many of you registered already. Help us spread the word wherever you are!

March 16-20 | Hands-on medical imaging training All levels welcome

Bring your questions, your data, and your curiosity! 💙

Join us: https://t.co/WDDBrAgH0m

[Hesheng Liu @hesheng3]

It’s time to rethink Parkinson’s disease. Our work reframes PD as a disorder of the somato-cognitive action network (SCAN), and shows that normalization of SCAN connectivity represents a shared mechanism across diverse effective therapies.
https://t.co/OuqOQcOcYq
@ndosenbach @DavidRen555 @iamzhangvv @bttyeo @foxmdphd

[Penn Medicine CSO @PennMedCSO]

New research out in @nature delineates two replicable axes of human white matter development ft. @audreycluo & @sattertt (@PennPsych) @CHOP_Research https://t.co/AhFbjx6SbU

[Ted Satterthwaite @sattertt]

@NoahSPhilipMD @foxmdphd thanks @NoahSPhilipMD !!!!!

[Ted Satterthwaite @sattertt]

massive congrats @JonahPadawer + all-- super important work!!!! so happy to see it out!!!!

[Jonah Padawer-Curry @JonahPadawer]

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵

https://t.co/x3KbEcEawP
#Neuroscience #Psychedelics #BrainImaging

[Junhao (Hao) Wen @JunhaoWen]

Trained as a computer scientist and bioengineer, I am over the moon to publish our paper (Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders) at @NatureBME: https://t.co/vJgrm2KPgv. Thanks to all collaborators @AndrewZalesky @lishenlc @yetianmed @USCLONI @erdem___varol @NeuroAI_Lab @ZhijianYang97 @HaochangS @sattertt, my mentor @chrisdav66 , and Barbara Cheifet for advancing the paper review process! @columbiaimaging @ColumbiaBME @nygenome @ZuckermanBrain @PennMedicine @DataSciColumbia Here is the open-access link: https://t.co/to9Uf3WCm3

[Ted Satterthwaite @sattertt]

Phenomenal work -- must read -- bravo!!

[Yapei Xie @XieYapei]

(1/10) How do brain networks and cognition co-evolve as children enter adolescence?

While valuable, cross-sectional studies offer only a single snapshot of brain–cognition relationships, missing the dynamic changes that longitudinal designs can reveal.

We hypothesize that cross-sectional and longitudinal estimates may diverge, echoing classical Simpson’s paradox.

As illustrated below:
To test this, we analyzed longitudinal fMRI and cognitive data at baseline and Year 2 in ~3,000 individuals (ages 8.9–13.5) from the ABCD Study, spanning the transition from childhood to adolescence.

[Read the full paper here: https://t.co/0NShR7O6l8]