Parker Singleton

dad - senior scientist at - psychedelics and other fun stuff - aspiring urban homesteader -

[Parker Singleton @singletonion]

🍄 Our first https://t.co/ICdlySqJJl living systematic review and meta-analysis on psilocybin for depression is out now in @NatMentHealth. Here's what we found and the open science infrastructure we built to support it: 🧵

Open-Access Link: https://t.co/PhU4tad8Q8

[josh hardman @Josh__Hardman]

AbbVie: 'The Next Frontier of Psychedelic Science'

AbbVie just published an article on its website about psychedelics.

"It’s important to note that the investigation and use of psychedelic medicines is not new", one of its staff says in an interview.

[Neuropsychopharmacology @npp_journal]

#TWiNPP

A living systematic review and meta-analysis supports MDMA-assisted therapy as a promising treatment for PTSD / @singletonion @sattertt

https://t.co/tEfJtb0gsx

[D. Parker Kelley @sequencemyneuro]

Are psychedelics anti-inflammatory!?
I am beyond excited to present the first systematic review and meta-analysis of the immunomodulatory effects of serotonergic psychedelics!
https://t.co/CXNQNR7E9k

[Haley Maria Dourron @HDourron]

✨🧘🍄 New study 🍄🧘✨ Many people think that meditation & psychedelics might have similar effects. Our new study examines how beliefs & cognitive processes might be similar or different in consistent meditators versus psychedelic users
Share widely!

[Steven Meisler @StevenMeisler]

Excited that this paper, "Highly replicable multisite patterns of adolescent white matter maturation", has now been published in Neuron! It may be found at https://t.co/j242htoIEY. To freely access the paper for the next 50 days, please use this link: https://t.co/uiARLk8MOR

[Parker Singleton @singletonion]

Now out in NPP (open-access): https://t.co/1VJitGPGw9

[Parker Singleton @singletonion]

🍄 Our second installment of https://t.co/ICdlySqJJl, a living systematic review and meta-analysis on MDMA for PTSD is now live on medRxiv. Here's what we found and how we built upon our open science infrastructure to support it 🧵

https://t.co/KSUPAKJdjW

[Parker Singleton @singletonion]

Out now in NPP: https://t.co/0qdIrxaocV

[Parker Singleton @singletonion]

🍄 Our second installment of https://t.co/ICdlySqJJl, a living systematic review and meta-analysis on MDMA for PTSD is now live on medRxiv. Here's what we found and how we built upon our open science infrastructure to support it 🧵

https://t.co/KSUPAKJdjW

[Parker Singleton @singletonion]

@ikesharpless WoT (still)

[Stanford University @Stanford]

The most important briefings of the day.

Karl Deisseroth, professor of bioengineering and of psychiatry and behavioral sciences, shares the news of his Nobel Prize with his kids.

[josh hardman @Josh__Hardman]

Man I miss Twitter

[David B. Yaden @ExistWell]

New paper, by me & @r_ehrenkranz (former postdoc at @TheYadenLab, now asst prof of biostats at @NorthwellHealth): We validated & shortened the Persisting Effects Questionnaire (PEQ), used to measure pos and neg changes after psychedelic exp-144 items to 14, w/ 3 stand-alone items

[Parker Singleton @singletonion]

4-arm psilocybin for depression trial out of Pakistan: https://t.co/lrlFnpO5RJ

[Anil Seth @anilkseth]

An extraordinary @Nature paper has just landed from the lab of @Sergiu_P_Pasca at @Stanford - led by Konstantin Kaganovsky. They have found a way to create "xenocortical mice" which have ~92% of their cortex occupied by a cortical organoid derived from human stem cells. This human-derived cortical graft integrates deeply with the host nervous system, supporting organised neural activity and behaviour.

This study is a milestone in synthetic biology and chimera research. It has the potential to generate multiple medical breakthroughs by providing an enhanced biological model of human brain tissue that allows behavioural as well as neural and genetic assays.

The Stanford team have been exceptionally thorough and proactive in addressing ethical concerns that comes from this frontier work. But their pioneering work nonetheless raises many open questions: are the xenocortical mice conscious? Do they have any human-like properties of consciousness or cognition?

@NitaFarahany and I will be addressing some of these questions in a forthcoming commentary - where we'll also offer an ethically-informed roadmap to guide this important research as it progresses. In this context, "pacing the frontier" really does make sense 😉

Read the Stanford @nature paper here, and buckle up. It's wild. https://t.co/Ky9HFb9nYI

[wex @lexiebu]

we’re losing the ancient texts

[Joshua Rosenblat, MD, MSc, FRCPC @JD_Rosenblat]

See our RCT published today @JAMAPsych

Serial Ketamine Infusions for Treatment-Resistant Bipolar Depression (TRBD)

In TRBD, adjunctive IV ketamine was well tolerated and associated with significant antidepressant effects.

@UofTPsych @KBI_UHN @UHN

https://t.co/bZLqN3VNHJ

[Anthropic @AnthropicAI]

In neuroscience, global workspace theory holds that thoughts become consciously accessible when they enter a privileged workspace that’s broadcast across the brain.

Using a new interpretability technique, we found something similar in Claude: the J-space. https://t.co/sLu2JgYwOQ

[Ted Satterthwaite @sattertt]

Awesome new work by Taylor Salo and @singletonion — a small but valuable test-retest dataset comparing single & multi-echo fMRI. Completely open + fully processed!!!!

[Parker Singleton @singletonion]

Huge thanks to all of the co-authors! This data was collected as part of an internal initiative and later brought to the public via a hackathon! @sattertt

[Parker Singleton @singletonion]

New dataset out in Data in Brief 🧠
We're releasing an open, test-retest neuroimaging dataset built for directly comparing single-echo vs. multi-echo fMRI, head-to-head, in the same people.
🔗 https://t.co/jjIP0VFiYE

[Parker Singleton @singletonion]

Full derivatives are included too: MRIQC, fMRIPrep, tedana, and XCP-D outputs on OpenNeuro, plus Nilearn outputs on NeuroVault.
🔗 https://t.co/3POWhKZCB2