CULLINAN

• Physics student •

Dharma •

Humanity first •

highly ambitious •

AWAKENED OPTIMIST •

[CULLINAN @garvitaryan]

Which one are you Anon ?

[CULLINAN @garvitaryan]

⚪Whitepill – Optimism. Faith in the future. We will do great.
🔴Redpill – Awakening. Seeing through lies. Criticism rooted in truth.
🔵Bluepill – Delusion. Comfort in illusion. Acceptance of falsehood.
⚫Blackpill – Doomerism.
Hopelessness. Belief that nothing will improve.

[Swanand @_swanand]

How much revenue are they expecting from the Indian market to go all this way?

₹250crore, which would be a huge blockbuster, is still $26.25m, almost a pocket change for a Nolan film

[CULLINAN @garvitaryan]

Hope he wins

[Bryan Johnson @bryan_johnson]

My plan to cure autoimmune gastritis

To our knowledge, no one has ever done this to try and cure an autoimmune disease.

Context: In May, I got diagnosed with autoimmune gastritis (AIG). We found it by taking a tissue biopsy of my stomach. My immune cells are confused, causing my stomach to eat itself.

AIG stops your body from absorbing nutrients like iron and B12, and can eventually lead to cancer. It likely started decades ago when I was diagnosed with hypothyroidism when 21 years old. The thyroid and stomach are closely linked in your immune system.

I feel fortunate that I've been taking such good care of my body for the past five years as my condition would otherwise be much more severe. Millions of people are affected by this disease and are undiagnosed.

Standard of care tells you that you can’t do anything about it. That’s old fashioned.

Here is how we are going to try and cure it:

Step 0: find and diagnose the disease ✅

AIG is rarely caught early because symptoms are subtle. Early warnings are low iron and B12, but when hemoglobin and hematocrit look normal, doctors routinely miss it because there are no obvious signs of anemia.

A standard colonoscopy won't find it either, because it only checks the lower digestive tract, not the stomach. It was only through a highly targeted stomach biopsy that we found it. Even biopsies can miss it if they don't sample the exact right spots. Most people with AIG go undiagnosed.

Step 1: Map my immune system ✅

Last Thursday, I had a blood draw to isolate and decode 1 million of my immune cells. Think of your immune cells as trillions of soldiers. Each carries a unique key designed to unlock and destroy a specific threat, like a virus or bacteria.

A standard blood test allows you to see how many soldiers you have, but not their keys. Sequencing one million individual immune cells allows us to read the exact pattern of the teeth on every single key.

This is important for my autoimmune gastritis (AIG) because a specific platoon of rogue soldiers has developed keys that unlock an attack on my stomach lining.

Right now, we don’t know who they are. This test will inform us of which soldiers have gone rogue and are attacking me from within.

Once we know the soldier and key, we know what therapy path to pursue to shut them down.

Step 2: Catch the rogue soldiers

I will be getting a second biopsy from my stomach because we need to collect live tissue. We are currently planning out the logistics of getting the sample from my stomach to the lab.

We need these live cells because the initial blood tests showed the antibodies, which prove that an attack is happening, but doesn’t show us the actual rogue soldier doing the damage which is a T-cell.

The live sample will allow us to match the immune system mapping we did to the live T-cells.

Step 3: Build an early warning system

To keep an eye on the disease as we work towards a therapy, we’re building an early warning system. I'll have my blood drawn every two weeks and we’ll pair that information with wearable data to look for flare ups. This is important because the attack happens without producing symptoms that I can easily feel.

Step 4: Create a “Bryan in a dish” testing model, a miniature of my immune system

At the same time, we are taking a massive sample of my immune cells and deep freezing them (cryopreservation) for two reasons:

a) we’ll create a living lab: using these cells to replicate my immune environment in a lab dish. This allows us to test experimental drugs and therapies on my actual live cells before putting them into my body.

b) it creates a back up plan for me by preserving the raw cellular material needed for targeted rejuvenation therapies in the future.

Step 5: Build precision guided therapies to end the attack

Once we know who the rogue soldiers are, we will engineer a therapy designed uniquely for them. The trick is only turning off the rogue soldiers while leaving all the other healthy ones functioning as they are.

For safety checks, we’ll do two test runs:

1) we’ll run the therapy through a computer model that has my biology to evaluate how my molecules interact.

2) We will take my actual cells that we froze in Step 4 and watch them interact for real.

If both are successful, we’ll pursue one of four therapies:

a) fix the mistake my cells are making, restoring my immune system's natural off switches

b) teach the rogue cells to tolerate my stomach instead of attacking it

c) design smart molecules that physically plug into the rogue cells and turn them off

d) build soldiers who will track down and eliminate the rogue soldiers causing the damage

[CULLINAN @garvitaryan]

Perfect example of Zeke Yeager Effect

[𝙎 @Alreadysad__]

Wimbledon ja ke bhi gaon dehat type pose 😭😭😭

[CULLINAN @garvitaryan]

Bryan Johnson be like :

[Clown World ™ 🤡 @ClownWorld]

Bryan Johnson spends $2 million a year and has a team of 30 doctors trying to reverse aging. He takes over 100 supplements a day, follows a strict plant based diet, exercises obsessively, and tracks every metric imaginable. He just announced his stomach has an incurable autoimmune disease and has been eating itself from the inside for years without him knowing.

[CULLINAN @garvitaryan]

@ExHighIQ But this one is different... Apple tv shows are different...

[CULLINAN @garvitaryan]

widows bay is such a good series, what a mix horror and comedy.
must watch.

[CULLINAN @garvitaryan]

@ExHighIQ things changed in last few months... 😁

[CULLINAN @garvitaryan]

your life will definitely become better with mahila mitra interaction...

[~𝙍𝘼𝙂𝙃𝙐🧧 @RAGHU_MBVK]

Men Life Without Women Interaction:

[CULLINAN @garvitaryan]

waaah re ladle...

roads, airports, railway lines are all about people.

[ANI @ANI]

Rahul Gandhi: Their speeches are about roads, airports, railway lines. They never talk about poor, about people

[CULLINAN @garvitaryan]

Poor here doesn't necessarily mean materially poor.

[CULLINAN @garvitaryan]

And in the next life, you can be a different gender, caste, race, or nationality.

[𐌁𐌉Ᏽ 𐌕𐌉𐌌𐌉 @OrevaZSN]

There is no evidence reincarnation is linear. Your next life could be thousands of years ago.

[CULLINAN @garvitaryan]

New pick up line -
I am nitin gadkari... Will you be my ethanol ? 🥰💖🥰💖🤩

[The Analyzer (News Updates🗞️) @Indian_Analyzer]

🚨 ETHANOL STOVES NEXT?

Bhaskar reports the Govt is preparing a blueprint for ethanol-based "SUPER BLUE" cooking stoves.

— Reportedly, 1 litre of ethanol can power a stove for up to 15 hours, compared to roughly 3 hours from an LPG cylinder equivalent.

[CULLINAN @garvitaryan]

@ExHighIQ It isn't showing from my other id,
Refresh it then see

[CULLINAN @garvitaryan]

What ?

[Buzz Crave @BuzzCrave_]

Sadie Sink will play Wanda Maximoff in 'Spider-Man: Brand New Day'.

[CULLINAN @garvitaryan]

@ExHighIQ done, is it still showing ?

[CULLINAN @garvitaryan]

@ExHighIQ Luck will always play a major role.

[CULLINAN @garvitaryan]

i think success instead of intelligence makes more sense.

[Boring_Business @BoringBiz_]

Still think about this

[CULLINAN @garvitaryan]

@ExHighIQ Done...Thank you... 🫡

[CULLINAN @garvitaryan]

@HeatblastRises Jai team black! 🫡🫡🫡

[CULLINAN @garvitaryan]

@TheFallenOne089 @namakpani India got Latent

[CULLINAN @garvitaryan]

@_khamoshii_ Gukesh in long hair look majestic 🤩