Gary Michael Satin

Biochemistry major with a minor in neuroscience. Interested in aging, AD, and other neurodegenerative diseases. #rank1 #sewanee #biochemistry #neuroscience

[David Sinclair @davidasinclair]

Wearables need a setting called “lie to me”

[David Sinclair @davidasinclair]

Disagree. We now have many examples of age reversal, even in primates

[ᴬᵀᴹ @dillonatm]

Nah any Marathon addicts better start sharing this link with your PC homies

[David Sinclair @davidasinclair]

Increased epigenetic stability in monkeys 👏

[The Longevity Forum @Longevity_Forum]

Rapamycin, a drug originally used to suppress immunity, may boost lifespan in animals as effectively as dietary restriction. Human trials are still needed.

https://t.co/EXCXDxFvJU

[David Sinclair @davidasinclair]

👏 Do at least one thing that scares you, every day - that’s the secret

[David Sinclair @davidasinclair]

My partner Serena’s mom is dying from ALS. The NIH grant supporting the scientists in my lab working hard on a cure was just terminated. No words

[Dr. Rhonda Patrick @foundmyfitness]

Cold exposure could help promote sleep by enhancing parasympathetic activity—but the timing is crucial.

Immediately after cold exposure you get a rush of sympathetic drive. That's why it makes you feel awake and alert. But in the ensuing hours you’ll see a massive down regulation, potentially as much as a 20–60% increase in HRV. This will help, rather than hinder, sleep onset and quality.

So while some will recommend a warm bath or a shower soon before bed, a properly timed cold exposure may be even better. My husband swears by it.

I discuss other strategies to promote sleep and recovery with @DrAndyGalpin in the latest episode of the FoundMyFitness podcast.

[David Sinclair @davidasinclair]

The polyphenol fisetin found in strawberries clears senescent cells in diabetic mice to prevent aortic aging. Combined with metformin it shows even better effects 🍓🧵

[David Sinclair @davidasinclair]

NEW STUDY: 50-80% of us will experience back pain in our lives. OSK is shown to alleviate cellular senescence 🧟 & back pain 🐀 suggesting epigenetic reprogramming might address this major economic burden & #1 cause of human disability… 🧵

[David Sinclair @davidasinclair]

What’s Pseudohypoxia?

It’s when muscles think they are starved for oxygen & produce less energy...but have ample oxygen, just low NAD

New review on countering this decline with pharmacological agents: 🧵

[David Sinclair @davidasinclair]

Alzheimer's disease (AD) patients experience a damaging mitochondrial stress response. New study shows the NAD-booster NMN lowers the stress, neuronal loss & brain atrophy in a mouse model of AD. Will be interesting to see if NAD booster MIB-626 benefits patients. Boston clinical trial @BrighamWomens https://t.co/yl6Aj37Sx4

[Nir Barzilai @NirBarzilaiMD]

This supports our proposal to repurpose FDA approved drugs to target aging. We predicted this based on the hallmarks of aging that this drug targets - even more than mTOR inhibition. https://t.co/oiGVFO6Bte

[Gary Michael Satin @garysatin]

@BradStanfieldMD Is that even a proper sample size 👀

[Moderna @moderna_tx]

Each person’s #cancer is different, which is why it can be difficult to treat. Hear more from @cleoabram about how we’re researching an individualized treatment approach specific to each person's #tumor, with the goal of training their immune system to fight back.

[David Sinclair @davidasinclair]

Some containers release as many as 4.22 million microplastic and 2.11 billion nanoplastic particles within 3 min of microwave heating. Refrigeration for over six months can also release billions of microplastics and nanoplastics 😮

[David Sinclair @davidasinclair]

Increase chances of working for a longevity biotech:
1. Study biology, chem, biocomputing, and/or business
2. Work for a start-up or longevity lab
3. Seek to improve lives
4. Know the literature
5. Attend meetings & events
6. Never give up

Global hot spots:
1. Boston, SF, San Diego, NYC
2. London, Madrid, Copenhagen
3. Tel Aviv, Abu Dhabi, Riyadh
4. Singapore, Beijing

Message https://t.co/NJwR2pLiv0 @ahlresearch for more info✌️

[Gary Michael Satin @garysatin]

@harriet_oglesby @HotTopic What a steal

[Gary Michael Satin @garysatin]

@davidasinclair @ahlresearch @AFARorg @LBA_longevity @TheA4li @NirBarzilaiMD @BuckInstitute @agingdoc1 Congratulations Professor Sinclair! 🙌🏻

[David Sinclair @davidasinclair]

Taurine, an amino acid, extends 🐁 lifespan 10% at human equivalent doses of 2.5-5g a day. Energy drinks: 1000 mg. My thoughts & reservations in today’s @nytimes @ElieDolgin https://t.co/ZPPGsnUdjh