Gianni Castiglione

Vanderbilt Asst. Prof, Biological Sciences, Ophthalmology & Visual Sciences

[Gianni Castiglione @giannicast]

Our newest paper is out in Science! This riddle took 5 years to solve. Genome annotation and AI missed it. Manual inspection and serendipity still have advantages for cracking nature's secrets! With @ScienceMagazine @EvolutionVU @RokasLab

| Science https://t.co/QUXxFLOHrF

[VU Chemical Biology @VICB_Vanderbilt]

Big news from Vanderbilt! 🎉 Dr. Gianni Castalione’s latest paper in Science explores groundbreaking findings, and VICB's High-Throughput Screening (HTS) facility is proud to have contributed to this important work.

🔬 Read more: https://t.co/IkbwNva4ZN

@VanderbiltU #research

[Gianni Castiglione @giannicast]

Thrilled to be featured on the @BBC for our work in @ScienceMagazine !!

(starts at 21:25)
https://t.co/ZBprkU00XI

[Gianni Castiglione @giannicast]

https://t.co/qxjbGprn5o

[Gianni Castiglione @giannicast]

https://t.co/0bGWjMCMOA

[Gianni Castiglione @giannicast]

https://t.co/NL7PVD19Tc

[EvolutionVU @EvolutionVU]

🏇 Horses evolved a viral trick to outrun damage.
The @giannicast Lab found a rare mutation that supercharges muscle energy—without the usual side effects.
New study in @ScienceMagazine.
🔬 @vanderbiltu #evolution #genetics #Science2025

[Gianni Castiglione @giannicast]

@big_data_kane @yale_eeb @Jenn_Coughlan @TJNear Thank you Brandon! Was just incredible talking to you today. Hope our paths cross again in the near future.

[Gianni Castiglione @giannicast]

Had a fantastic visit as the seminar speaker @yale_eeb ! Really stimulating conversations with such down to earth and creative people @Jenn_Coughlan @big_data_kane @TJNear thanks for the invite!

[Gianni Castiglione @giannicast]

@Jenn_Coughlan @yale_eeb @big_data_kane @TJNear Thank you so much, Jenn. Was so great talking to you, thanks for everything!

[Gianni Castiglione @giannicast]

Excited to have our new paper highlighted AND on the cover in MBE!

[Molecular Biology and Evolution @MolBioEvol]

Excited to share MBE's first Highlight! Learn how Antarctic icefishes have adapted to see under the ice -- Looking through the Ice: Cold-Adapted Vision in Antarctic Icefish https://t.co/AjQtum87VE @giannicast @EvolutionVU @opsinlab @franceshauser @alexvn @UofTCellSysBiol

[Gianni Castiglione @giannicast]

@EvolutionVU Thanks everyone! Very excited to be here

[Gianni Castiglione @giannicast]

@DrRamBio That's amazing!! Glad its being put to good use.

[Gianni Castiglione @giannicast]

Our paper is out! w @HopkinsMedicine We explore how certain ACE2 mutations granting natural resistance to #SARSCoV2 infection will likely never evolve in humans (but maybe in dogs!)
https://t.co/BNIZjxUaPc.

[PLOS Biology @PLOSBiology]

Doomed by our physiology? @giannicast &co argue that, because of epistasis acting on #ACE2, ancient events in mammalian #cardiovascular evolution determined the host range of #SARSCoV2 millions of years before the current pandemic #PLOSBiology https://t.co/1c8QVj9c75

[Gianni Castiglione @giannicast]

@IBIS_journal @NatureComms Find out more about our study in our #behindthepaper blog post in @NatureEcoEvo https://t.co/3Cl65CMBqC

[Gianni Castiglione @giannicast]

Birding in Baltimore: Avian Antioxidant Innovations Predate Modern Medicine by 65 Million Years https://t.co/rORbKhxSRr #behindthepaper

[Gianni Castiglione @giannicast]

@LabDeNicola @LauredelaVega That's right! We (the authors) noticed in the literature that KEAP1 knockout mice die of keratin overexpression, and wondered how birds would handle it. We found antioxidant response elements at feather keratin loci in avian skin, and detected NRF2 occupancy!

[Nature Communications @NatureComms]

Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds:
https://t.co/RJ54v4cEUC

@giannicast

[Gianni Castiglione @giannicast]

@AAElbassiouny Thanks Ahmed!!

[Gianni Castiglione @giannicast]

We found that #Birds have supercharged antioxidants! They lost the master off-switch controlling antioxidant gene expression. This is a major clinical target, which could explain why birds have such long lifespans. Thanks to @LightsOutBalt @NatureComms

https://t.co/iJhrKswdBj