Yep, and Medigene $MDG1 had all the tools for best in class engineered T cells in their toolbox. And still it went bust...
Interested to hear a good take on that story
Everyone's racing to engineer T cells for solid tumors. One of the most striking pediatric brain-cancer results this year came from T cells that weren't engineered at all.
Children's National just published a Phase 1 in Nature Medicine: multi-antigen T cells targeting WT1, PRAME and survivin — non-gene-modified, delivered by simple IV — in children with DIPG and relapsed CNS tumors. DIPG is a death sentence; median survival is roughly a year.
The primary endpoint was safety, and it cleared. The signal underneath is the story: three children in the relapsed arm remain disease-free with no further treatment — the longest past four years — including one complete remission. And it's a non-engineered approach, built to sidestep the neurotoxicity that makes CAR-T so hard to run in the brain.
The read for markets: the only public company built on this exact modality is Marker Therapeutics. Its MT-601 stacks those same three antigens plus three more, and it's aimed squarely at patients who've already failed CD19 CAR-T.
Single-target CAR-T has the spotlight. This is the counter-thesis worth watching.
$MRKR $GILD $XBI $IBB
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It looks like investing, it's golden like investing, but it is not investing.
It's gambling.
Reminds me of this cult French 1980s advertisement for Canada Dry
https://t.co/7l5XLVqaqn
Ondo Perps just launched in pre-alpha as a 24/7 platform for trading perpetual futures tied to tokenized stocks, commodities and indexes.
Users can trade with up to 20x leverage and use tokenized stocks as collateral across markets like $NVDA , $TSLA, $AAPL, $AMD, $META and $PLTR.
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After Belgium scored their 4th goal vs USA, the whole team mocked President Donald Trump by doing his signature dance move
Pretty savage troll, especially on US soil & after Trump fought to have FIFA review the bogus red card suspension on Balogun.
Well played 🤝
#TheRuleOfLaw applies to sports too.
#KleptocratInChief is unaware of this basic fact and of so many other realities outside of his immediate narcissistic aura. He's got this unique capacity of corrupting into the micro alveolar level of society
🚨 𝗢𝗙𝗙𝗜𝗖𝗜𝗔𝗟: Statement from UEFA on FIFA overturning Folarin Balogun's one-match suspension:
"Yesterday's decision to suspend for a probationary period of a year the
implementation of the one-match automatic suspension following the red card issued to the player Folarin Balogun crossed a red line."
"Football, like any other sports, relies on rules, which are the basis for fair, honest and transparent competition. Sometimes rules are open to interpretation. In this case not."
"A minimum automatic suspension of one match following a red card is not a discretionary option and does not require the decision of a competent body to be enacted. It is a principle embedded in regulations, which cannot be made subject to exceptions, let alone in the middle of a tournament where several other players have been in the same situation and regularly served their suspension."
"When the certainty of rules is no longer guaranteed by its guardians, the integrity of the game is at stake and the credibility of a competition is undermined. Equally, such decision creates a precedent in the ongoing tournament, where similar situations will now require an equal treatment, to the detriment of the competition."
"Football is the most loved sport in the world because it is a beautiful game and is trusted because it is played everywhere with the same laws. A tournament is never a pure standalone and, if the tournament in question is the World Cup, it has the power to drive positive or negative consequences on the game as a whole."
"We express our disbelief at such an unprecedented, incomprehensible and unjustifiable decision."
I’ve studied these two and written biographies’ worth of articles on them. They are a unique byproduct of deeply abusive families and an apartheid education system that trained them to believe they were the superior race.
They were also taught to hate people like themselves.
Peter Thiel was a young gay boy in a town & a school that were the last places in the world to use “Heil Hitler” as a greeting. Peter both believes he is superior but also that he is defective. That’s why he’s a dedicated transhumanist. He wants to ESCAPE this world—and himself—by any means necessary.
Elon is the quintessential incel—an asocial nerd with sociopathic, abusive, racist parents. He got put in the hospital for being an asshole at school. He morphed his father’s sci-fi bedtime stories and his apartheid brainwashing into a grandiose delusions of being the emperor of a colony on Mars—white people only.
The result is a messianic malignant narcissist who believes he has the right to enact a eugenics program on the world—“for our own good.” USAID was just the start.
Elon Musk doesn’t think “takers” should vote. He thinks empathy is suicidal. He actively stokes race war.
For Peter and Elon, the emotional compression of both hating everyone who doesn’t look like them AND hating themselves created genocidal monsters—because they there is nowhere to run. They’re trapped in their own private hell and they don’t care who it hurts to escape.
They found each other 30 years ago and started collaborating on the project of burning down American constitutional democracy so they can create a corporate feudalist dictatorship from the ashes. They see human life as dirty, unnecessary, and complicated. They want death—a lot of it.
Erich Fromm, who defined the term “malignant narcissist” would have called them necrophiles. They much prefer machines to people.
The American system not only failed to filter out these extraordinarily evil creatures but actively elevated them to a position of being able to present an existential danger as they do now. That failure is a cross-section of everything that needs to change.
These are the exact people we should never allow to call themselves Americans, much less give them untold billions of our tax dollars to destroy the very systems they used to obtain their obscene hoards of wealth.
We became too tolerant, too weak, and too complacent.
We have to kick this evil out or be swallowed by it. Those are the only two choices.
@DestinationTele évidemment ILS veulent fermer CNews, MOI aussi je veux fermer CNews ! La règle est simple, information n'est pas opinion. Quand on l'ignore si ouvertement, si longtemps, la fermeture s'impose.
Pas de FOXNews à la française.
Que @PascalPraud aille faire le mariole sur Youtube
@realDonaldTrump I think you got a bit cocky there Mr President. No fantasy characters to entertain #NarcissistInChief, real Americans, blessed with TDS and most importantly, a healthy bank account. They are going to sue your ass off. Enjoy 😎
@realDonaldTrump I think you got a bit cocky there Mr President. No fantasy characters to entertain #NarcissistInChief, real Americans, blessed with TDS and most importantly, a healthy bank account. They are going to sue your ass off. Enjoy 😎
@DestinationTele@PascalPraud J'ai découvert ce clip en cherchant un commentaire de foot, c'est dans cet exercice que je l'ai découvert dans les '80s. Il a commencé sa carrière avec la mention passable, il la termine avec la mention minable.
#TheRuleOfLaw
@DestinationTele évidemment ILS veulent fermer CNews, MOI aussi je veux fermer CNews ! La règle est simple, information n'est pas opinion. Quand on l'ignore si ouvertement, si longtemps, la fermeture s'impose.
Pas de FOXNews à la française.
Que @PascalPraud aille faire le mariole sur Youtube
@michaeljburry STOP saying I LOVE YOU every time they set foot outside of the house.
And when in doubt, always go back to Khalil Gibran's poem
https://t.co/diqgDIhHlm