Glocentrica.com

Glyoxalase 1 inducer (GlucoRegulate) - counters glycolytic overload and methylglyoxal for treatment of insulin resistance, diabetes & MASLD; & for healthy aging

[Glocentrica.com @Glo1inducer]

Glocentrica Ltd website launched at https://t.co/H5R5CiaERn Excited to introduce #Glo1inducer supplement - effective inhibitor of unfolded protein response (UPR) in #hyperglycemia & treatment of insulin resistance. Maintains metabolic health & supports healthy #aging. @altos_labs

[Paul J Thornalley @pjthornalley]

#Throwback
Unraveling the impaired incretin effect in obesity and type 2 diabetes: Key role of hyperglycemia-induced unscheduled glycolysis and glycolytic overload.
https://t.co/cMQN7S5wuA

[GloVitality @glovitalityuk]

People with impaired fasting #glucose (IFG), impaired glucose tolerance (IGT) & both IFG+IGT have decreased #insulin sensitivity - as judged by oral glucose insulin sensitivity (OGIS) index. Supplement #GlucoRegulate corrects this. See how it can help you. https://t.co/jOAfnhoKQn

[Paul J Thornalley @pjthornalley]

@Anand_ETHZ @NatMetabolism @CUMedicalSchool @Princeton Primary role of fructose metabolism in the liver appears to be lifting of GKRP inhibition of glucokinase to enhance glycolytic overload. See https://t.co/c9VBIZ7rys

[Paul J Thornalley @pjthornalley]

@Cell_Metabolism Here’s more detailed coverage of the role of glucose and fructose metabolism. https://t.co/c9VBIZ7rys

[GloVitality @glovitalityuk]

People with impaired fasting #glucose (IFG), impaired glucose tolerance (IGT) & both IFG+IGT have decreased #insulin sensitivity - as judged by oral glucose insulin sensitivity (OGIS) index. Supplement #GlucoRegulate corrects this. See how it can help you. https://t.co/jOAfnhoKQn

[GloVitality @glovitalityuk]

@peptidepilled GlucoRegulate (previously known as Glo1 inducer) activates #Nrf2 to induce glucose-6-phosphate dehydrogenase and prevent glycolytic overload in the liver, skeletal muscle and adipose tissue. See papers https://t.co/sXfXq3HgSI and https://t.co/sLsBMhYeP3.

[GloVitality @glovitalityuk]

People with impaired fasting #glucose (IFG), impaired glucose tolerance (IGT) & both IFG+IGT have decreased #insulin sensitivity - as judged by oral glucose insulin sensitivity (OGIS) index. Supplement #GlucoRegulate corrects this. See how it can help you. https://t.co/jOAfnhoKQn

[Paul J Thornalley @pjthornalley]

@NatureRevEndo Glycolytic overload crucial in #incretin effect impairment, triggering need for #tirzepatide-like drugs. Supplement #GlucoRegulate corrects this. Need studies to see if safe & highly tolerated GlucoRegulate can preserve health benefits secured. #obesity. https://t.co/cMQN7S5wuA

[Paul J Thornalley @pjthornalley]

@EricTopol @NPR Reminds me of the promise in the 1990s of glutathione diesters to increase cellular GSH for increased antioxidant capacity in aging. Treatment rather increased GSH catabolism and expected benefit was not realised.

[GloVitality @glovitalityuk]

@inabster @grok @meNabster @Bill_Grau2020 Good supplement for insulin resistance is #GlucoRegulate. Science-based, clinically studied. As good as #Mounjaro for insulin resistance improvement. Available on Amazon UK & https://t.co/jOAfnhoKQn

[Paul J Thornalley @pjthornalley]

@BoussageonR @bmj_latest Issue has been that to prevent vascular complications it has been unclear what we need to achieve in treatment to counter pathogenesis of #hyperglycemia. Key now seems to be prevention of stabilisation of HK2 to proteolysis and glycolytic overload. See https://t.co/5pS6kAaLE2

[Paul J Thornalley @pjthornalley]

@BBCNews Obesity is suggested as contributing; also inflammation. A tumor suppressor protein, glyoxalase 1 (Glo1), is decreased by these conditions. We optimised a supplement, #Glucoregulate, to increased this and correct insulin levels. Maybe help in cancer prevention. @JamesTGallagher

[Glocentrica.com @Glo1inducer]

@ScienceMagazine @ScienceTM 👏 Endothelial dysfunction in diabetes starts with glucose-induced stabilisation to proteolysis and all dysfunction from the thereby enabled increased flux of glucose metabolism flowed from there. See https://t.co/6N93vZmKIn and https://t.co/S38JnR0y9l

[Glocentrica.com @Glo1inducer]

@ScienceMagazine @ScienceTM 👏 Endothelial dysfunction in diabetes starts with glucose-induced stabilisation to proteolysis and all dysfunction from the thereby enabled increased flux of glucose metabolism flowed from there. See https://t.co/6N93vZmKIn and https://t.co/S38JnR0y9l

[Paul J Thornalley @pjthornalley]

@DiabetologiaJnl 👏Interesting. Genotypes of GCRP are considered particularly influential in youth wrt #MASLD risk. Major effect of dietary fructose (high in youth) is lifting of the protective effects of GCRP. #glycolyticoverload See https://t.co/c9VBIZ7rys

[Paul J Thornalley @pjthornalley]

Happy to be presenting on “Laboratory measurement of protein #glycation in the era of precision #medicine – biomarkers of metabolic dysfunction and health decline” at #EFLM Strategic Conference 2026 in Prague later this week https://t.co/EGLlqPQOMe for https://t.co/tjDCLKsM8P

[Paul J Thornalley @pjthornalley]

@robertlufkinmd 👏Important to get a quantitative view. Production of #fructose from glucose accounts for only ca. 10% total fructose exposure and a major damaging effect of fructose in the #liver is lifting GKRP slowing of glucose metabolism through formation of F1P. See https://t.co/c9VBIZ7rys

[Paul J Thornalley @pjthornalley]

On #WorldLiverDay2026, the “Glycolytic overload” hypothesis explains how sugar-rich diets drive the development of #MASLD. #Fructose is damaging through lifted GKRP protection. Supplement #GlucoRegulate may offer protection/early-stage treatment. See https://t.co/c9VBIZ7rys

[Paul J Thornalley @pjthornalley]

@NatMetabolism 👏 Or is dietary #fructose particularly damaging because it lifts the inhibition on glucose metabolism by GKRP in the liver and induces fructolytic enzymes? See https://t.co/c9VBIZ7rys

[GloVitality @glovitalityuk]

@davidasinclair Correcting insulin resistance would delay multiple diseases. Supplement #GlucoRegulate does this. As effective as GLP-1/GIP agonist in clinical trial. Not a replacement for it but highly tolerated and taken once daily by mouth, something to consider. https://t.co/jOAfnhoKQn