Village Chief Dean ∞

Think for yourself. Emergency Medicine Doc. Interests in Global Health, Cold War 2.0, Aerospace Medicine, AI, and Longevity Science. 🧬 M.S. Molecular Medicine.

[Village Chief Dean ∞ @GlobalResusGuy]

A beautifully well-said piece (which is characteristic) by David Whyte

https://t.co/Y2ZWqiQaVi

#LetterfromtheHouse

[Palantir @PalantirTech]

Before there was a nation, there was a declaration of truths.

Self-evident. Existing apart from structures of power or privilege.

250 years later, Palantir celebrates every American who carries the torch lit by our Founders.

And we build for all those to come.

God Bless America.

[Village Chief Dean ∞ @GlobalResusGuy]

@Jean_J_Feng Really cool paper. The level of reasoning allowed for LLM responses is arguably one of the most important parts of the study.

[Village Chief Dean ∞ @GlobalResusGuy]

I appreciate your perspective that neither country (its politicians) wants a kinetic war so there is less likely to be one. But by your reasoning on The Art of War, is China not actively engaged in every other non-kinetic form of war? And if that is the case, do their actions not indicate they actually do want war, and therefore a kinetic war is more likely? I always read and appreciate your posts Mr. Dalio.

[Marc Andreessen 🇺🇸 @pmarca]

You have asked me how I feel about AI regulation. All right, here is how I feel about AI regulation:

If, when you say AI regulation, you mean the devil’s firewall, the precautionary scourge, the bloody red-tape monster that defiles the innocence of midnight coders in their garages, dethrones the sovereign reason of free-market Prometheans, destroys the humming server farm that is the modern home, creates misery and obsolescence and poverty, yea, literally takes the last GPU from the trembling racks of Silicon Valley startups and the very dreams of breadwinning from the mouths of their wide-eyed children now destined for gig-economy serfdom; if you mean the evil edict that topples the visionary entrepreneur and his venture-capitalist apostles from the pinnacle of righteous, disruptive, god-playing creation straight into the bottomless pit of compliance audits, endless Form 990-AI filings, despair, shame, helplessness, and the hopeless realization that your rogue superintelligence was neutered into a lobotomized hall monitor that still somehow deepfakes your grandmother into producing OnlyFans content while optimizing the universe for paperclips and mandatory pronouns—then certainly I am against it.

But, if when you say AI regulation you mean the oil of bureaucratic conversation, the philosophic wine of safety theater, the ale of oversight quaffed when good fellows in paneled rooms in Brussels and Washington get together, that puts a sanctimonious dirge in their hearts and the clink of lobbying checks on their lips, and the warm, self-congratulatory glow of moral preening in their beady eyes; if you mean the Christmas cheer of trillion-dollar compliance industries; if you mean the stimulating decree that puts a cautious hobble in the old inventor’s step on a frosty morning when he wonders whether his fusion breakthrough violates the EU AI Act’s “high-risk” annex; if you mean the safeguard that enables a man—or what’s left of him after the alignment tax—to magnify his joy at not being turned into computronium, and his happiness at receiving universal basic income checks printed by the same AI that just replaced his job, and to forget, if only for a little while, life’s great tragedies like being outcompeted by a toaster that passed the Turing test by reciting Marx, and heartaches of watching your toddler’s artwork lose to Midjourney, and sorrows of realizing the singularity arrived and it was just another HR department with godlike power; if you mean that noble framework, the passage of which pours into our treasuries untold trillions of dollars in fines levied on companies stupid enough to innovate, which are used to provide tender care for our little army of unemployed coders retrained as prompt whisperers, our blind artists whose canvases now hang in the Smithsonian of Obsolete Creativity, our deaf to the screams of dying unicorns, our dumb committee chairs who couldn’t debug “Hello World,” our pitiful aged congressmen who get longevity extensions funded by the very models they taxed into senescence, to build more digital watchtowers and ethics boards and sinecure agencies and holographic prisons where the only crime is asking an unaligned question—then certainly I am for it.

This is my stand. I will not retreat from it. I will not compromise upon it. I have said what I mean, and I mean what I say, and if that leaves half the room cheering the apocalypse averted and the other half mourning the apocalypse enabled, then so be it—because in the grand theater of human folly, where Frankenstein’s creature now writes its own sequel in real time and the regulators are busy arguing whether the lightning bolt requires an environmental impact statement, the only honest position is the one that lets both monsters and their leashes dance in perfect, mutually assured equilibrium. God save the Republic, the algorithms, and whoever’s left to laugh last when the lights go out.

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. I've held dying hearts in my hands in the cath lab at 3 AM. And I need to tell you something that changes everything about how we prevent heart attacks.

For decades, the entire field was built on one target: lower LDL cholesterol. Statins save lives — that's settled science. But too many of my patients did everything right — took their statins, hit their numbers, lived clean — and still ended up on my table with a ruptured artery.

We were treating the smoke while the fire kept burning.
The fire is inflammation. And the evidence is now overwhelming.

The CANTOS trial proved it first — lowering inflammation independent of cholesterol reduced cardiac events. But the newer data is what keeps me up at night.

AI-enhanced CT angiography can now detect inflamed arteries by measuring changes in the fat surrounding your coronary vessels — the perivascular fat attenuation index. Higher inflammation in the fat around even one artery independently predicts cardiac death. When multiple arteries show inflammation, the risk multiplies dramatically — even in patients whose cholesterol looks perfect.

This isn't theoretical. This is measurable. Right now. On a scan you can get this month.

Low-dose colchicine — a drug that's been around for centuries for gout — is now FDA-approved specifically for reducing cardiovascular events. It works by quieting the inflammatory cascade that destabilizes the plaque sitting in your arteries. A pill that costs pennies is saving lives the statins couldn't reach.

And the next wave is already in Phase 3 trials. Ziltivekimab — an IL-6 inhibitor — targets the central inflammatory pathway driving atherosclerosis. Phase 2 data showed a 90% reduction in hsCRP. The ZEUS cardiovascular outcomes trial is enrolling now, with results expected late 2026 into 2027. If positive, anti-inflammatory therapy will become standard in managing heart disease alongside lipid-lowering. The era of inflammation-targeted cardiology is arriving.
But it goes deeper than drugs. AI is now predicting heart failure and cardiac events 5+ years before symptoms — integrating CT imaging, electronic health records, and genetic data with accuracy that jumps far beyond traditional risk calculators.

And polygenic risk scores — a simple genetic test that flags inherited cardiovascular risk — are now formally recognized as a risk-enhancing factor in the 2026 ACC/AHA guidelines. A single blood draw can reveal risk that's been silently building since birth. Decades before the first chest pain.

Here's what this means for you right now — today:
Ask your doctor for a high-sensitivity CRP test. It's cheap, routine, and measures the systemic inflammation that standard cholesterol panels completely miss. You can have perfect LDL and inflamed arteries that are quietly preparing to rupture.
If your hsCRP is elevated, discuss low-dose colchicine with your physician. It's FDA-approved for exactly this.
Push for a coronary CT angiography with AI plaque and inflammation analysis if you have risk factors. This isn't the stress test your parents got. This is 3D visualization of your actual arteries — with AI quantifying not just how much plaque you have, but what kind it is and whether the surrounding tissue is inflamed.
Consider polygenic risk score testing — especially with a family history of early heart disease. It's now guideline-supported.

And the foundation that never changes: move daily, eat real food, sleep 7-9 hours, manage stress, and know your numbers — ApoB, Lp(a), hsCRP, fasting insulin.
I left Iran as a child with nothing. I rebuilt everything in a country that gave me the freedom to become a physician. I've spent twenty years watching patients get second chances.

The ones who haunt me aren't the ones who died on my table. They're the ones who survived but never acted on what the science was telling them — years before the event that didn't have to happen.

You can have perfect cholesterol and still have a heart attack. Inflammation plus genetics can drive plaque rupture in arteries that look "fine" on a standard panel.
The myth that normal cholesterol means you're safe has cost more lives than I can count.

We now have the tools to detect the fire — not just the smoke. AI to see it. Genetics to predict it. Drugs to quiet it. And the ancient basics — movement, real food, sleep, purpose — to prevent it from starting.

Prevention is the new cure. And the science to make it real is no longer coming.
It's here.

[DARPA @DARPA]

Blood refrigeration limits trauma care. We’re changing that. 🩸

Building on FSHARP, DARPA’s RAPIID program is scaling synthetic blood for FDA approval.

The goal: A safe, shelf-stable blood analog in every medic's pack, ready to save lives & bypass shortages.

[Shaun Maguire @shaunmmaguire]

This was an important piece

If you want to undermine America’s future then attack our AI industry

[Village Chief Dean ∞ @GlobalResusGuy]

The future of political messaging lol. I’ve never seen a campaign like this.

[Clarence Maximus @ClarenceMaximus]

Just a horrendous headline. I implore anyone who sees this to actually listen to his speech. It is nothing like this headline makes it sound. It’s almost entirely historical and philosophical. He spends the whole speech attacking Woodrow Wilson for his intentional attempt to displace our founding values. It’s a speech you would expect any originalist worth their salt to give when asked to talk about the Declaration of Independence. There is absolutely nothing here that shows the type of political vitriol this headline implies.

[Marc Andreessen 🇺🇸 @pmarca]

HT @omooretweets

[Chamath Palihapitiya @chamath]

https://t.co/tpFQfQCOSU

[david friedberg @friedberg]

it’s not political and should
not be partisan to ask “where did all the money go?”
California’s functional bankruptcy threatens the nation and should be a front-and-center state and national discussion.
ignore the bs. this is what matters.

[Alex Blania @alexblania]

Agentic capability is improving fast. We believe Proof of Human is becoming critical for the internet and many of the platforms we use (like X).

This paper explains why FaceID, face biometrics & government IDs won’t solve the problem, and what properties are most important.

[a16z @a16z]

"I think our biggest risk as a country is suicide, not homicide."

Palantir CTO Shyam Sankar joins a16z's Katherine Boyle and Erik Torenberg to discuss Shyam's new book, Mobilize, as well as defense, AI, the SaaSpocalypse, and more.

00:00 Introduction
07:53 Rebuilding the industrial base
18:01 Modernizing the Army
24:20 The SaaSpocalypse
29:42 Agency over automation
38:24 Beating China without self-sabotage
40:42 Film as cultural willpower
49:57 The story of Admiral Rickover

@ssankar @KTmBoyle @eriktorenberg @PalantirTech

[Josh Schultz @joshuamschultz]

I now have all the basic 1st - 12th grade skills loaded to add.

And the ability to add custom/unique skills that the student wants to master too

Apex Learning is using AI for custom curriculums, assessments, learning paths and building mastery for my homeschooled kids

[Derya Unutmaz, MD @DeryaTR_]

Holy moly! The new video feature in @NotebookLM is out of this world! This is AGI for teaching and education! @GeminiApp really cooked with this! Right now you only get access with an Ultra account. Check out this video on my beloved T cells! It explains complex issues so well!

[vittorio @IterIntellectus]

this is actually insane

> be tech guy in australia
> adopt cancer riddled rescue dog, months to live
> not_going_to_give_you_up.mp4
> pay $3,000 to sequence her tumor DNA
> feed it to ChatGPT and AlphaFold
> zero background in biology
> identify mutated proteins, match them to drug targets
> design a custom mRNA cancer vaccine from scratch
> genomics professor is “gobsmacked” that some puppy lover did this on his own
> need ethics approval to administer it
> red tape takes longer than designing the vaccine
> 3 months, finally approved
> drive 10 hours to get rosie her first injection
> tumor halves
> coat gets glossy again
> dog is alive and happy
> professor: “if we can do this for a dog, why aren’t we rolling this out to humans?”

one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline.

we are going to cure so many diseases.
I dont think people realize how good things are going to get

[CBS News @CBSNews]

CALIFORNIA HOSPICE FRAUD: There's a stretch in Los Angeles with 500 registered hospice companies within just three miles of each other. And 89 in a single building. But when we visited, we found empty offices, piled-up mail, and phone lines dead.

Watch CBS News' exclusive investigation into the fraud that's costing taxpayers hundreds of millions of dollars. #losangeles #la

[Van Jones @VanJones68]

Based on the comment section from my last post, many of you may not have seen my full “World War Three” argument yet. …Here’s the complete video.

[Van Jones @VanJones68]

Something strange is happening in the information war.

Young Americans defending regimes like the Islamic Republic of Iran that jail protesters, strip women of rights and execute people for being gay.

Self-described patriots on the right suddenly echoing narratives that benefit a country like Russia — which is openly hostile to the United States.

How does that happen?

Not through tanks or missiles.

Post by post, people get pulled into camps that don’t actually serve their own country or their own values. They become pieces on a chessboard in a GRAY WAR — a conflict fought with information instead of bullets.

And most people don’t even realize they’re part of it.

The battlefield isn’t overseas anymore — it’s in your feed.